Wenyang Li

Immune Checkpoint Inhibitor Rechallenge in Unresectable Hepatocellular Carcinoma: A Multicenter Efficacy and Safety Study

Jing-Kun Chen, Jia-Liang Wei, Zhen‐Dong Yang, Shaoping Liu et autres

Introduction: Immune checkpoint inhibitors (ICIs) are a standard treatment for unresectable hepatocellular carcinoma, but sometimes they must be discontinued because of resistance or immune-related adverse events. The present study explored whether later resuming ICI therapy in such patients ("rechallenge") can improve their …

cn (code pays fourni par la source)

VDR activation ameliorates intermittent hypoxia-related cognitive impairment by upregulating TREM2 transcription

Jiahuan Xu, Hongyu Jin, Hui Shen, Hong Huang et autres

Neuroinflammation induced by intermittent hypoxia (IH) plays an essential role in the cognitive impairment associated with obstructive sleep apnea (OSA). It has been reported that the activation of Vitamin D receptor (VDR) can alleviate the neuroinflammation and neuronal injury in some neurodegenerative …

cn (code pays fourni par la source)

Pulmonary cryptococcosis in the setting of immunosuppression by methylprednisolone monotherapy for oral pemphigus: a case report and literature review

Hongxia Mei, Zhi Wei, Qinbo Yang, Chen Chen et autres

Cryptococcosis is an opportunistic and potentially fatal fungal infectious disease. Pemphigus diseases are characterized by blistering of the cutaneous and mucous membranes. We report a case of pulmonary cryptococcosis (PC) following methylprednisolone treatment for pemphigus vulgaris. Additionally, we analyzed a case series …

cn (code pays fourni par la source)

Detection of Varicella Zoster Virus Reactivation in Cerebrospinal Fluid in Ischemic Stroke or Transient Ischemic Attack

Wenyang Li, Peter V. Sguigna, Chintan Rupareliya, Suriya Subramanian et autres

Background Epidemiological data suggest that the risk of ischemic stroke increases after varicella‐zoster virus (VZV) reactivation. The frequency of VZV reactivation in acute ischemic stroke (AIS) is unknown. The risk of recurrent stroke and the antiviral treatment effect, particularly in patients with …

us (code pays fourni par la source)

Research status and future perspectives of IL‑27 in the treatment of stroke (Review)

Weiqin Liu, Zhenyou Zou, Wenyang Li, Guang Yang et autres

Stroke is a life‑threatening cerebrovascular disorder categorized into two major subtypes: Ischemic and hemorrhagic. Characterized by high morbidity and mortality rates, its clinical management remains challenging due to limited therapeutic options. Interleukin (IL)‑27, a pleiotropic cytokine with demonstrated neuroprotective potential, has emerged …

cn (code pays fourni par la source)

Prevalence and impact of fertility preservation among young women with breast cancer

Min Chen, Xuan Wang, Ning Lan, YanKe Chen et autres

To observe the current situation of fertility preservation among female breast cancer patients ≤ 40 years old and analyze the related factors which influence the utilization of fertility preservation. A single-center retrospective questionnaire was conducted investigating patients diagnosed with breast cancer attending …

cn (code pays fourni par la source)

IL-27-mediated Inflammatory Microenvironment After Stroke: Research Status, Future Delivery Strategies and Challenges

Weiqin Liu, Zhenyou Zou, Wenyang Li, Guang Yang et autres

Stroke is a serious cerebrovascular disease that can be classified into two types: ischemic and hemorrhagic. It has a high mortality and disability rate, and current methods of prevention and treatment are limited. One promising cytokine that may help in the prevention …

cn (code pays fourni par la source)

Selective HDAC8 inhibition by PCI-34051 attenuates inflammation and airway remodeling in asthma via miR-381-3p-TGFβ3 axis

Shiyao Bai, Xinming Su, Delei Kong, Chenye Feng et autres

Background and Objectives: Histone deacetylase (HDAC) families regulate various physical processes and the development of several diseases. The role of HDACs in asthma development and progression worths further investigation. This study aims to evaluate the effect of HDACs in a mouse model …

cn (code pays fourni par la source)

Discovery and Total Synthesis of Anhydrotuberosin as a STING Antagonist for Treating Autoimmune Diseases

Fusheng Guo, Jing Zhang, Yihui Gao, Zhou Shu et autres

Abstract Excessive activation of the stimulator of the interferon gene (STING) pathway has been identified as a significant contributor to various autoimmune diseases, such as STING‐associated vasculopathy with infantile‐onset (SAVI) and inflammatory bowel disease (IBD). However, discovering effective STING antagonists for treating …

cn (code pays fourni par la source)

VrNIN1 interacts with VrNNC1 to regulate root nodulation in mungbean

Yanzheng Zhang, Xiaolin Yao, Xiaotong Wang, Wenyang Li et autres

cn (code pays fourni par la source)

Relationship between Indel Variants within the JAK2 Gene and Growth Traits in Goats

Xianfeng Wu, Qian Xu, Ao Wang, Xianyong Lan et autres

Janus kinase 2 (JAK2) plays a critical role in myoblast proliferation and fat deposition in animals. Our previous RNA-Seq analyses identified a close association between the JAK2 gene and muscle development. To date, research delving into the relationship between the JAK2 gene …

cn (code pays fourni par la source)

Fibrillarin modulates fetal hemoglobin silencing

Dongliang Wu, Qi‐Xiang Li, Sipei Qiu, Chan Guo et autres

Abstract Decoding the molecular mechanisms underlying human fetal (γ) globin gene silencing impacts therapeutic strategies for β-thalassemia and sickle cell disease. Here, we identified a nucleolar protein, fibrillarin (FBL), which mediates the methylation of glutamine104 in histone H2A and functions as a …

cn, au (code pays fourni par la source)