Accès ouvert
2025
article
OpenAlex
Fengling Hu, Zheng Ren, Luyun Chen, Alessandra M. Valcarcel et autres
Multiple sclerosis (MS) is characterized by central nervous system lesions detectable via MRI. Existing diagnostic criteria incorporate presence of white matter lesions, but specificity can be improved using MS-specific imaging biomarkers, including paramagnetic rim lesions (PRLs) and central vein sign (CVS). However, …
us, fr, ca, it
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Accès ouvert
2024
article
OpenAlex
Luyun Chen, Zheng Ren, Kelly A. Clark, Carolyn Lou et autres
BACKGROUND AND PURPOSE: Paramagnetic rim lesions (PRLs) are an MRI biomarker of chronic inflammation in people with multiple sclerosis (MS). PRLs may aid in the diagnosis and prognosis of MS. However, manual identification of PRLs is time-consuming and prone to poor interrater …
us, ca
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Marvin Petersen, Mirthe Coenen, Charles DeCarli, Alberto De Luca et autres
White matter hyperintensities of presumed vascular origin (WMH) are associated with cognitive impairment and are a key imaging marker in evaluating brain health. However, WMH volume alone does not fully account for the extent of cognitive deficits and the mechanisms linking WMH …
de, nl, us, at, ch, sg, ca
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Accès ouvert
2024
article
OpenAlex
Andrew An Chen, Kelly A. Clark, Blake E. Dewey, Anna L. DuVal et autres
Dimension reduction tools preserving similarity and graph structure such as t-SNE and UMAP can capture complex biological patterns in high-dimensional data. However, these tools typically are not designed to separate effects of interest from unwanted effects due to confounders. We introduce the …
us
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Accès ouvert
2024
article
OpenAlex
David R. Roalf, Donna M. McDonald‐McGinn, Joelle Jee, Mckenna Krall et autres
BACKGROUND: Minor physical anomalies (MPAs) are congenital morphological abnormalities linked to disruptions of fetal development. MPAs are common in 22q11.2 deletion syndrome (22q11DS) and psychosis spectrum disorders (PS) and likely represent a disruption of early embryologic development that may help identify overlapping …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Kelly A. Clark, Carly M. O’Donnell, Mark A. Elliott, Shahamat Tauhid et autres
BACKGROUND AND PURPOSE: Multicenter study designs involving a variety of MRI scanners have become increasingly common. However, these present the issue of biases in image-based measures due to scanner or site differences. To assess these biases, we imaged 11 volunteers with multiple …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Kelly A. Clark, Abby R. Manning, Luyun Chen, Fang Liu et autres
Objective To determine early magnetic resonance imaging (MRI) features of new multiple sclerosis (MS) lesions that will develop into paramagnetic rim lesions (PRLs), which have been associated with progressive tissue injury in MS. Methods New contrast‐enhancing lesions observed on routine clinical MRI …
us
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Accès ouvert
2023
article
OpenAlex
Abigail R. Manning, Erin Beck, Matthew K. Schindler, Govind Krishna Kumar Nair et autres
Abstract Background and Purpose Cortical demyelinated lesions are prevalent in multiple sclerosis (MS), associated with disability, and have recently been incorporated into MS diagnostic criteria. Presently, advanced and ultrahigh‐field MRIs—not routinely available in clinical practice—are the most sensitive methods for detection of …
us
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Andrew An Chen, Kelly A. Clark, Blake E. Dewey, Anna L. DuVal et autres
Abstract Dimension reduction tools preserving similarity and graph structure such as t -SNE and UMAP can capture complex biological patterns in high-dimensional data. However, these tools typically are not designed to separate effects of interest from unwanted effects due to confounders. We …
us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Danni Tu, Manu S. Goyal, Jordan D. Dworkin, Samuel D. Kampondeni et autres
A central challenge of medical imaging studies is to extract biomarkers that characterize disease pathology or outcomes. Modern automated approaches have found tremendous success in high-resolution, high-quality magnetic resonance images. These methods, however, may not translate to low-resolution images acquired on magnetic …
us, Malawi
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Kelly A. Clark, Carly M. O’Donnell, Mark A. Elliott, Shahamat Tauhid et autres
Abstract Background/Purpose Multicenter study designs involving a variety of MRI scanners have become increasingly common. However, these present the issue of biases in image-based measures due to scanner or site differences. To assess these biases, we imaged 11 volunteers with multiple sclerosis …
us
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Carolyn Lou, Pascal Sati, Martina Absinta, Kelly A. Clark et autres
BACKGROUND AND PURPOSE: The presence of a paramagnetic rim around a white matter lesion has recently been shown to be a hallmark of a particular pathological type of multiple sclerosis lesion. Increased prevalence of these paramagnetic rim lesions is associated with a …
us
(code pays fourni par la source)