Intersite brain MRI volumetric biases persist even in a harmonized multisubject study of multiple sclerosis
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Le résumé fourni par la source
BACKGROUND AND PURPOSE: Multicenter study designs involving a variety of MRI scanners have become increasingly common. However, these present the issue of biases in image-based measures due to scanner or site differences. To assess these biases, we imaged 11 volunteers with multiple sclerosis (MS) with scan and rescan data at four sites. METHODS: Images were acquired on Siemens or Philips scanners at 3 Tesla. Automated white matter lesion detection and whole-brain, gray and white matter, and thalamic volumetry were performed, as well as expert manual delineations of T1 magnetization-prepared rapid acquisition gradient echo and T2 fluid-attenuated inversion recovery lesions. Random-effect and permutation-based nonparametric modeling was performed to assess differences in estimated volumes within and across sites. RESULTS: Random-effect modeling demonstrated model assumption violations for most comparisons of interest. Nonparametric modeling indicated that site explained >50% of the variation for most estimated volumes. This expanded to >75% when data from both Siemens and Philips scanners were included. Permutation tests revealed significant differences between average inter- and intrasite differences in most estimated brain volumes (P < .05). The automatic activation of spine coil elements during some acquisitions resulted in a shading artifact in these images. Permutation tests revealed significant differences between thalamic volume measurements from acquisitions with and without this artifact. CONCLUSION: Differences in brain volumetry persisted across MR scanners despite protocol harmonization. These differences were not well explained by variance component modeling; however, statistical innovations for mitigating intersite differences show promise in reducing biases in multicenter studies of MS.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Intersite brain MRI volumetric biases persist even in a harmonized multisubject study of multiple sclerosis
- Date Crossref
- 16/08/2023
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Pennsylvania Department of Biostatistics pays non établi dans la noticeUniversité ou école supérieure
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Brigham and Women's Hospital Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Harvard University pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins University Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins Medicine pays non établi dans la noticeÉtablissement de santé
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National Institutes of Health Quantitative MRI Core Facility pays non établi dans la noticeOrganisme public
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National Institute of Neurological Disorders and Stroke Quantitative MRI Core Facility pays non établi dans la noticeStructure de recherche
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Cedars-Sinai Medical Center Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Department of Neurology Cedars‐Sinai Medical Center Los Angeles California USA Neuroimaging Program pays non établi dans la noticeÉtablissement de santé
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Perelman School of Medicine Center for Neuroinflammation and Neurotherapeutics pays non établi dans la noticeUniversité ou école supérieure
Department of Biostatistics — University of Pennsylvania, Department of Neurology — Brigham and Women's Hospital et Harvard University, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.