Thorir Hardarson

Deep learning versus manual morphology-based embryo selection in IVF: a randomized, double-blind noninferiority trial

Peter J. Illingworth, Christos A. Venetis, David K. Gardner, Scott McGill Nelson et autres

To assess the value of deep learning in selecting the optimal embryo for in vitro fertilization, a multicenter, randomized, double-blind, noninferiority parallel-group trial was conducted across 14 in vitro fertilization clinics in Australia and Europe. Women under 42 years of age with …

gr, au, gb, se, dk (code pays fourni par la source)

Correlations between a deep learning-based algorithm for embryo evaluation with cleavage-stage cell numbers and fragmentation

Aisling Ahlström, Jørgen Berntsen, Martin Blok Johansen, Christina Bergh et autres

RESEARCH QUESTION: Do cell numbers and degree of fragmentation in cleavage-stage embryos, assessed manually, correlate with evaluations made by deep learning algorithm model iDAScore v2.0? DESIGN: Retrospective observational study (n = 5040 embryos; 1786 treatments) conducted at two Swedish assisted reproductive technology …

se, it (code pays fourni par la source)

P-134 An artificial intelligence method based on time-lapse images and deep learning may predict if a day2/3 embryo will form a utilizable blastocyst

Aisling Ahlström, J Berntsen, M Johansen, Thorir Hardarson et autres

Abstract Study question Can iDAScore v2.0 predict likelihood of development into a utilizable blastocyst from time-lapse images captured during the first two or three days of embryo development? Summary answer iDAScore v2.0 predicts utilizable blastocyst formation from time-lapse images of early embryo …

se, it (code pays fourni par la source)

P-136 An embryo evaluation algorithm based on deep learning correlates strongly with cell number and degree of fragmentation on day 2 and 3

Kersti Lundin, J Berntsen, M Johansen, Thorir Hardarson et autres

Abstract Study question Does the embryo evaluation model iDAScore v2.0 correlate with manually assessed cell numbers and fragmentation grade in early-stage embryos? Summary answer iDAScore v2.0 significantly correlated with morphological assessment of preimplantation embryos on days 2 and 3. Correlation between cell …

se, it (code pays fourni par la source)

A double-blind randomized controlled trial investigating a time-lapse algorithm for selecting Day 5 blastocysts for transfer

Aisling Ahlström, Kersti Lundin, Anna‐Karin Lind, Kristina Gunnarsson et autres

STUDY QUESTION: Can use of a commercially available time-lapse algorithm for Day 5 blastocyst selection improve pregnancy rates compared with morphology alone? SUMMARY ANSWER: The use of a time-lapse selection model to choose blastocysts for fresh single embryo transfer on Day 5 …

se (code pays fourni par la source)

Comprehensive analysis of soluble RNAs in human embryo culture media and blastocoel fluid

Kirstine Kirkegaard, Yan Yan, Boe Sandahl Sørensen, Thorir Hardarson et autres

PURPOSE: miRNAs have been suggested as biomarkers of embryo viability; however, findings from preliminary studies are divergent. Furthermore, the presence of other types of small RNA molecules remains to be investigated. The purpose of this study was to perform a comprehensive analysis …

dk, se (code pays fourni par la source)

Single Embryo Transfer

Thorir Hardarson, Matts Wikland

se (code pays fourni par la source)

Adjuncts in the IVF laboratory: where is the evidence for ‘add-on’ interventions?

Joyce Catherine Harper, Emily Jackson, Karen Sermon, R. John Aitken et autres

Globally, IVF patients are routinely offered and charged for a selection of adjunct treatments and tests or 'add-ons' that they are told may improve their chance of a live birth, despite there being no clinical evidence supporting the efficacy of the add-on. …

gb, be, au, ie, se, fr (code pays fourni par la source)

Patients experience of viewing time-lapse sequences: A prospective survey study

Annika Bladh Blomquis, Raghad Samir, Ann-Britt Engström, Staffan Nilsson et autres

The use of time-lapse monitoring in ART is spreading rapidly and is already considered an important part of treatment in many centers internationally, but studies are lacking on patients experience of using this technology. We consider it important not to forget patient-oriented …

se (code pays fourni par la source)

Transplanting embryonic stem cells onto damaged human corneal endothelium

Charles A. Hanson, Ársæll Már Arnarsson, Thorir Hardarson, Ann Lindgård et autres

AIM: To investigate whether human embryonic stem cells (hESCs) could be made to attach, grow and differentiate on a human Descemet's membrane (DM). METHODS: Spontaneously differentiated hESCs were transferred onto a human corneal button with the endothelial layer removed using ocular sticks. …

se, us, is (code pays fourni par la source)

Birthweight and the effects of culture media

Jeremy G. Thompson, Michael J. Davies, Thomas B. Pool, Laura Francesca Rienzi et autres

Sir, Ensuring and monitoring the health of children conceived through IVF is paramount, of that there can be no compromise. Hence, we found it perplexing to read the paper by Kleijkers et al. (2016) on the effects of culture media and birthweight. …

au, us, it, se (code pays fourni par la source)

Perspectives on results from cryopreservation/thawing cycles

Julius Gisli Hreinsson, Thorir Hardarson, Anna‐Karin Lind, Staffan Nilsson et autres

Sir, We read with interest the paper by Groenewoud et al. (2016), recently published in Human Reproduction. The authors performed an ambitious multi-centre trial aimed at evaluating whether the artificial cycle is inferior, or equal to, the modified natural cycle for cryopreserved-thawed …

se (code pays fourni par la source)