Line Kristensen

Corrigendum to “Impact of oxygen deprivation on the FLASH effect for skin toxicity in a murine model” [Radiother. Oncol. 214 (2026) 111277]

Anna Holtz Hansen, P.R. Poulsen, Line Kristensen, Valentin Vacari Møller et autres

dk (code pays fourni par la source)

FIRST IN-VIVO RANGE VERIFICATION FOR SMALL-ANIMAL PROTON THERAPY USING IN-BEAM PET WITH ONLINE IMAGE RECONSTRUCTION.

Giulio Lovatti, Munetaka Nitta, Francesco Evangelista, Gabriele Corbetta et autres

data from 20 upcoming patients and investigate the relationship between temporal changes in the k₂-Maps and follow-up outcomes.

de, it, dk (code pays fourni par la source)

Equivalent constant dose rate as a unifying dose rate concept for FLASH across all beam time structures

P.R. Poulsen, Brita Singers Sørensen, Line Kristensen, Jacob Johansen

Background The FLASH effect has been investigated experimentally using beam modalities with different time structures such as pulsed electron beams and pencil beam scanning (PBS) proton fields. The different beam time structures make direct comparisons between experiments difficult. A biologically founded dose …

dk (code pays fourni par la source)

Impact of oxygen deprivation on the FLASH effect for skin toxicity in a murine model

P.R. Poulsen, Line Kristensen, Valentin Vacari Møller, Priyanshu M. Sinha et autres

BACKGROUND: FLASH radiotherapy has emerged as a promising modality capable of reducing normal tissue toxicity while maintaining tumor control comparable to conventional dose rate (CONV) radiotherapy. Despite growing interest, the underlying biological mechanisms remain unclear. This study investigates the dependency of FLASH …

dk (code pays fourni par la source)

Determining the effects of hyperthermia on the tumor and acute normal tissue response of FLASH radiation

Priyanshu M. Sinha, Line Kristensen, Charlemagne Asonganyi Folefac, Lars Hjorth Præstegaard et autres

INTRODUCTION: There is limited indication of how hyperthermia would influence the unique proposition of FLASH radiation - its ability to maintain comparable tumor response while offering protection to normal tissues. Hence, this study was designed to investigate the potential of combining FLASH …

dk (code pays fourni par la source)

Fractionation increasingly reduces FLASH sparing for acute murine skin damage

Line Kristensen, Sky Rohrer, Jacob Johansen, Lone Hoffmann et autres

BACKGROUND AND PURPOSE: Preclinical studies report a favourable normal tissue-sparing FLASH effect. Most studies report single-fraction irradiations. The interplay between fractionation and FLASH sparing is highly relevant for clinical translation but is scarce in the literature. This study compared the tissue-sparing effect …

dk (code pays fourni par la source)

Fixation method influences FLASH skin sparing in an in vivo leg model

Line Kristensen, Cathrine Overgaard, Jacob Johansen, Anna Mette Hansen et autres

BACKGROUND AND PURPOSE: The FLASH effect, where ultra-high dose rate elicits a favourable normal tissue-sparing, has been shown in several preclinical studies. Study setup differences, for example fixation methods that affect blood flow, can influence radiation response but are unexplored for FLASH. …

dk (code pays fourni par la source)

Probing the therapeutic window of proton minibeam radiotherapy using dose-response curves in a mouse model

Fardous Reaz, Line Kristensen, Erik Tranéus, Brita Singers Sørensen et autres

PURPOSE: Proton minibeam radiotherapy (pMBRT) has been observed in preclinical studies to spare normal tissues through its spatially fractionated dose profile. Translating pMBRT to clinical application requires quantification of its therapeutic gain, compared to conventional proton therapy. We compare pMBRT to conventional …

dk, se (code pays fourni par la source)

4046 Equivalent constant dose rate as a unifying dose rate concept for FLASH across all beam time structures

P.R. Poulsen, Brita Singers Sørensen, Line Kristensen, Cai Grau et autres

2544 Fractionated FLASH irradiation reduces acute skin toxicity in a murine model.

Line Kristensen, Sky Rohrer, Jacob Johansen, Lone Hoffmann et autres

In Reply to Scifoni et al

P.R. Poulsen, Jacob Johansen, Mateusz Sitarz, Eleni Kanouta et autres

dk (code pays fourni par la source)

Electron vs proton FLASH radiation on murine skin toxicity

Line Kristensen, Sky Rohrer, Lone Hoffmann, Lars Hjorth Præstegaard et autres

BACKGROUND AND PURPOSE: Dose-response modification of FLASH has previously been established for acute skin toxicity in protons. This study used a similar experimental setup to quantify the dose-response modification of electron FLASH irradiation for acute skin- and late fibrotic toxicity in mice. …

dk (code pays fourni par la source)