Munetaka Nitta

FIRST IN-VIVO RANGE VERIFICATION FOR SMALL-ANIMAL PROTON THERAPY USING IN-BEAM PET WITH ONLINE IMAGE RECONSTRUCTION.

Giulio Lovatti, Munetaka Nitta, Francesco Evangelista, Gabriele Corbetta et autres

data from 20 upcoming patients and investigate the relationship between temporal changes in the k₂-Maps and follow-up outcomes.

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Radioactive ion beam adaptive treatment of mouse tumors using in-beam PET

M. Durante, Martina Moglioni, Tamara Vitacchio, Francesco Evangelista et autres

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FIRST IMAGE-GUIDED TREATMENT OF A MOUSE TUMOR WITH RADIOACTIVE ION BEAMS

Daria Boscolo, Giulio Lovatti, Olga Sokol, Tamara Vitacchio et autres

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First in-vivo IMPT Irradiation of Mice with Quasi-Real-Time Range Verification with the SIRMIO PET Scanner

Federica Evangelista, Giulio Lovatti, Marco Antonio Coutinho Pinto, Jonathan Frederik Bortfeldt et autres

As part of the SIRMIO project, we conducted the first in-vivo intensity-modulated proton therapy treatment of mice, integrating a dedicated beamline and an in-beam smallanimal PET scanner for quasi-real-time proton range verification. During an experimental campaign at the Danish Centre for Particle …

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Use of Inter-Detector Scattering Event for Sensitivity Improvement for an In-Beam Small Animal PET

Munetaka Nitta, Federica Evangelista, Giulio Lovatti, Jonathan Frederik Bortfeldt et autres

We have developed a small-animal in-beam positron emission tomography (PET) scanner as part of the “Small Animal Proton Irradiator for Research in Molecular Image-Guided Radiation Oncology” (SIRMIO) project, enabling accurate image-guided proton irradiation at clinical facilities. The scanner comprises 56 three-layer depth-of-interaction …

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Experimental assessment of novel PET detector components for online imaging of radioactive ion beams

Giulio Lovatti, Munetaka Nitta, Francesco A. Evangelista, Daria Boscolo et autres

Abstract Objective. This work aims to evaluate the ability of novel detector components to measure with submillimeter resolution in beam positron emission tomography (PET) signals produced by 10C and 11C radioactive ion beams stopped in PMMA targets and to validate a simulation …

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Image-guided treatment of mouse tumours with radioactive ion beams

Daria Boscolo, Giulio Lovatti, Olga Sokol, Tamara Vitacchio et autres

Abstract Charged particle therapy with protons or heavier ions is one of the most effective radiotherapy techniques, but uncertainties in the beam range can limit its efficacy. Radioactive ion beams are ideal for image-guided particle therapy because isotopes that undergo β + …

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Patient CT-based simulation study of secondary-electron-bremsstrahlung imaging for range verification in proton therapy: comparison with prompt gamma and PET imaging for simplified proton pencil beam and SOBP irradiation scenarios

Takuya Yabe, Munetaka Nitta, Mitsutaka Yamaguchi, Marco Antonio Coutinho Pinto et autres

Abstract Objective. Secondary electron bremsstrahlung (SEB) imaging, along with prompt gamma (PG) and positron emission tomography (PET) imaging, has been proposed as an in vivo range verification tool for proton therapy. This study presents the first simulation based on patient computed tomography …

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First image-guided treatment of a mouse tumor with radioactive ion beams

Marco Durante, Daria Boscolo, Giulio Lovatti, Olga Sokol et autres

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Effect of inter-crystal events inclusion on high resolution small-animal PET scanner performance

Federica Evangelista, Giulio Lovatti, Jonathan Frederik Bortfeldt, Zhe Huang et autres

Inter-crystal scattering (ICS) events cause mispositioning of annihilation events, leading to contrast degradation of Positron-Emission-Tomography (PET) images. In Depth-of-Interaction (DOI) detectors for high resolution PET scanners the ICS events rate increases due to the smaller size of the crystals. This results in …

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Characterization of the SIRMIO Spherical Small Animal PET toward Simultaneous Beam and Tracer Imaging

Munetaka Nitta, Giulio Lovatti, Federica Evangelista, Jonathan Frederik Bortfeldt et autres

We developed a small animal in-beam positron emission tomography (PET) scanner for accurate image-guided proton irradiation at clinical facilities within the project “Small animal proton Irradiator for Research in Molecular Image-guided radiation Oncology” (SIRMIO)”. The PET scanner is composed of 56 3-layer …

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First image-guided treatment of a mouse tumor with radioactive ion beams

Daria Boscolo, Giulio Lovatti, Olga Sokol, Tamara Vitacchio et autres

Radioactive ion beams (RIB) are a key focus of current research in nuclear physics. Already long ago it was proposed that they could have applications in cancer therapy. In fact, while charged particle therapy is potentially the most effective radiotherapy technique available, …