Brita Singers Sørensen

Corrigendum to “Impact of oxygen deprivation on the FLASH effect for skin toxicity in a murine model” [Radiother. Oncol. 214 (2026) 111277]

Anna Holtz Hansen, P.R. Poulsen, Line Kristensen, Valentin Vacari Møller et autres

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FIRST IN-VIVO RANGE VERIFICATION FOR SMALL-ANIMAL PROTON THERAPY USING IN-BEAM PET WITH ONLINE IMAGE RECONSTRUCTION.

Giulio Lovatti, Munetaka Nitta, Francesco Evangelista, Gabriele Corbetta et autres

data from 20 upcoming patients and investigate the relationship between temporal changes in the k₂-Maps and follow-up outcomes.

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IN VIVO PROTON RBE: LET AND DOSE DEPENDENCIES FOR EARLY AND LATE ENDPOINTS

Erlend Lyngholm, Camilla Stokkevåg, Christian Karger, Brita Singers Sørensen et autres

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Proton RBE for in vivo model systems: LET and dose dependencies for early and late biological endpoints

Erlend Lyngholm, Camilla H. Stokkevåg, Christian P. Karger, Brita Singers Sørensen et autres

Purpose Proton therapy applies a constant relative biological effectiveness (RBE) of 1.1, despite increasing evidence that RBE varies with physical and biological factors such as linear energy transfer (LET), dose, and tissue type. Variable RBE models from in vitro data may not …

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Tumor implantation site dictates the immune landscape of syngeneic mouse models of head and neck cancer

Klara Rasmussen Bollerup Lanng, Anders Etzerodt, Michael R. Horsman, Brita Singers Sørensen et autres

Syngeneic mouse models are widely used to study immune-mediated tumor responses. While these models are typically implanted in the flank of the mouse, some experimental setups require alternative sites of tumor implantation, such as the foot. It remains unclear how tumors in …

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Interplay between dose, dose rate and endpoint in the tissue sparing effect of FLASH radiotherapy

P.R. Poulsen, Jacob Johansen, Brita Singers Sørensen

FLASH tissue sparing involves an interplay between dose, dose-rate and investigated endpoint. A risk zone map that divides the two-dimensional dose - dose-rate-space into different toxicity risk zones based on previous in-vivo data illustrates this interplay intuitively, including why FLASH sparing manifests …

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Histological characterization and quantification of late damage in mice after proton and photon irradiation

Danny Mortensen, Cathrine Bang Overgaard, Jan Alsner, Jens Randel Nyengaard et autres

Purpose: Radiotherapy is a widely used cancer treatment, and radiation-induced fibrosis is a frequent late effect that can significantly reduce patients’ quality of life. Many approaches for evaluating and grading radiation late damage, such as fibrosis, are based on semi-quantitative methods. This …

Histological characterization and quantification of late damage in mice after proton and photon irradiation

Danny Mortensen, Cathrine Bang Overgaard, Jan Alsner, Jens Randel Nyengaard et autres

Purpose: Radiotherapy is a widely used cancer treatment, and radiation-induced fibrosis is a frequent late effect that can significantly reduce patients’ quality of life. Many approaches for evaluating and grading radiation late damage, such as fibrosis, are based on semi-quantitative methods. This …

Interplay between dose, dose rate and endpoint in the tissue sparing effect of FLASH radiotherapy

P.R. Poulsen, Jacob Johansen, Brita Singers Sørensen

Equivalent constant dose rate as a unifying dose rate concept for FLASH across all beam time structures

P.R. Poulsen, Brita Singers Sørensen, Line Kristensen, Jacob Johansen

Background The FLASH effect has been investigated experimentally using beam modalities with different time structures such as pulsed electron beams and pencil beam scanning (PBS) proton fields. The different beam time structures make direct comparisons between experiments difficult. A biologically founded dose …

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DIFFERENTIAL INFLAMMATORY RESPONSE AND TISSUE DAMAGE IN MOUSE HEAD AND NECK FOLLOWING PROTON VERSUS X-RAY RADIOTHERAPY

Nina Frederike Jeppesen Edin, Olga Zlygosteva, Inga Solgård Juvkam, Hilde Kanli Galtung et autres

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ENHANCING IMMUNOTHERAPY WITH PROTON- VS X-IRRADIATION IN MOUSE TUMOR MODELS

Anne Marit Rykkelid, Michael R. Horsman, Brita Singers Sørensen, Nina Frederike Jeppesen Edin et autres

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