Regina Shaw

TDP-43 dysfunction leads to the accumulation of cryptic transposable element-derived exons, crypTEs, in iPSC derived neurons and ALS/FTD patient tissues

Isobel Bolger, Regina Shaw, Oliver H. Tam, Cláudio Gouveia Roque et autres

TDP-43 is an RNA and DNA binding protein that plays major roles in regulating RNA processing. In particular, TDP-43 dysfunction leads to the accumulation of cryptic splice isoforms that result from improperly spliced mRNAs. In addition to its role in regulating splicing, …

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ALS molecular subtypes are a combination of cellular and pathological features learned by deep multiomics classifiers

Kathryn O’Neill, Regina Shaw, Isobel Bolger, Oliver H. Tam et autres

Amyotrophic lateral sclerosis (ALS) is a complex syndrome with multiple genetic causes and wide variation in disease presentation. Despite this heterogeneity, large-scale genomics studies revealed that ALS postmortem samples can be grouped into a small number of subtypes, defined by transcriptomic signatures …

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ALS molecular subtypes are a combination of cellular, genetic, and pathological features learned by deep multiomics classifiers

Kathryn O’Neill, Regina Shaw, Isobel Bolger, Oliver H. Tam et autres

Amyotrophic Lateral Sclerosis (ALS) is a complex syndrome with multiple genetic causes and wide variation in disease presentation. Despite this general heterogeneity, several common factors have been identified. For example, nearly all patients show pathological accumulations of phosphorylated TDP-43 protein in affected …

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Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

Oliver H. Tam, Nikolay V. Rozhkov, Regina Shaw, Duyang Kim et autres

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. While several pathogenic mutations have been identified, the vast majority of ALS cases have no family history of disease. Thus, for most ALS cases, the …

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Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

Oliver H. Tam, Nikolay V. Rozhkov, Regina Shaw, Duyang Kim et autres

Summary Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. While several inherited pathogenic mutations have been identified as causative, the vast majority of cases are sporadic with no family history of disease. Thus, …

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Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

Oliver H. Tam, Nikolay V. Rozhkov, Regina Shaw, Duyang Kim et autres

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Neuronal Transcriptome of Aplysia: Neuronal Compartments and Circuitry

Leonid L. Moroz, John R. Edwards, Sathyanarayanan V. Puthanveettil, Andrea B. Kohn et autres

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Rapid and accurate pyrosequencing of angiosperm plastid genomes.

Michael J. Moore, Amit Dhingra, Pamela S. Soltis, Regina Shaw et autres

BACKGROUND: Plastid genome sequence information is vital to several disciplines in plant biology, including phylogenetics and molecular biology. The past five years have witnessed a dramatic increase in the number of completely sequenced plastid genomes, fuelled largely by advances in conventional Sanger …

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Direct retransformation of yeast with plasmid DNA isolated from single yeast colonies using rolling circle amplification

Xiaodong Ding, Anita K. Snyder, Regina Shaw, William G. Farmerie et autres

We have efficiently amplified plasmid DNA from single yeast colonies using rolling circle amplification (RCA). The amplified DNA can be directly used for restriction digestion, DNA sequencing, or yeast transformation. The RCA-based high-fidelity amplification would be useful for plasmid manipulation in a …

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Complete Genomic Sequence of the Amsacta moorei Entomopoxvirus: Analysis and Comparison with Other Poxviruses

A. L. Bawden, Kathryn J. Glassberg, James Diggans, Regina Shaw et autres

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The Pleckstrin Homology Domain of Human βIΣII Spectrin Is Targeted to the Plasma Membranein Vivo

Deng-Shun Wang, Rehae Miller, Regina Shaw, Gerry Shaw

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Binding of Pleckstrin Homology Domains to WD40/β-Transducin Repeat Containing Segments of the Protein Product of the Lis-1 Gene

D.S. Wang, Regina Shaw, Mitsuharu Hattori, Hiroyuki Arai et autres

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