Chelsea R. White

RTN4IP1 is required for the final stages of mitochondrial complex I assembly and CoQ biosynthesis

Monika Oláhová, Rachel M. Guerra, Jack J. Collier, Juliana Heidler et autres

A biochemical deficiency of mitochondrial complex I (CI) underlies approximately 30% of cases of primary mitochondrial disease, yet the inventory of molecular machinery required for CI assembly remains incomplete. We previously characterised patients with isolated CI deficiency caused by segregating variants in …

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RTN4IP1 is essential for the final stages of mitochondrial complex I assembly and coenzyme Q biosynthesis

Monika Oláhová, Rachel M. Guerra, Jack J. Collier, Juliana Heidler et autres

Summary A biochemical deficiency of mitochondrial complex I (CI) underlies ∼30% of cases of primary mitochondrial disease, yet the inventory of molecular machinery required for CI assembly remains incomplete. We previously characterised patients with isolated CI deficiency caused by segregating variants in …

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Fecal microbiome transplantation and tributyrin improves early cardiac dysfunction and modifies the BCAA metabolic pathway in a diet induced pre-HFpEF mouse model

Jomana Hatahet, Tyler M. Cook, Raiza R. Bonomo, Nadia Elshareif et autres

More than 50% of patients with heart failure present with heart failure with preserved ejection fraction (HFpEF), and 80% of them are overweight or obese. In this study we developed an obesity associated pre-HFpEF mouse model and showed an improvement in both …

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Abstract MP228: The Role Of Gut Microbiome Secreted Short Chain Fatty Acids In The Development Of Heart Failure With Preserved Ejection Fraction HFpEF

Jomana Hatahet, Raiza R. Bonomo, Tyler M. Cook, Chelsea R. White et autres

More than 50% of patients with heart failure are diagnosed with heart failure with preserved ejection fraction (HFpEF), and 80% of them are obese. It is a prominent disease with no available treatments. It is characterized by diastolic dysfunction that involves increase …

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Loss of C2 Domain Protein (C2CD5) Alters Hypothalamic Mitochondrial Trafficking, Structure, and Function

Chaitanya K. Gavini, Chelsea R. White, Virginie Mansuy‐Aubert, Grégory Aubert

INTRODUCTION: Mitochondria are essential organelles required for several cellular processes ranging from ATP production to cell maintenance. To provide energy, mitochondria are transported to specific cellular areas in need. Mitochondria also need to be recycled. These mechanisms rely heavily on trafficking events. …

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Fecal transplantation and butyrate improve neuropathic pain, modify immune cell profile, and gene expression in the PNS of obese mice

Raiza R. Bonomo, Tyler M. Cook, Chaitanya K. Gavini, Chelsea R. White et autres

Obesity affects over 2 billion people worldwide and is accompanied by peripheral neuropathy (PN) and an associated poorer quality of life. Despite high prevalence, the molecular mechanisms underlying the painful manifestations of PN are poorly understood, and therapies are restricted to use …

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Molecular Mechanisms and Therapeutic Approaches of Myofilament Glycation as a Result of Diabetes

Maria Papadaki, Theerachat Kampaengsri, Raiza R. Bonomo, Chelsea R. White et autres

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Control of Staphylococcus aureus Quorum Sensing by a Membrane-Embedded Peptidase

Chance J. Cosgriff, Chelsea R. White, Wei Ping Teoh, James P. Grayczyk et autres

Gram-positive bacteria process and release small peptides, or pheromones, that act as signals for the induction of adaptive traits, including those involved in pathogenesis. One class of small signaling pheromones is the cyclic autoinducing peptides (AIPs), which regulate expression of genes that …

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Control of Staphylococcus aureus quorum sensing by a membrane-embedded peptidase

Chance J. Cosgriff, Chelsea R. White, Wei Ping Teoh, James P. Grayczyk et autres

Abstract Gram-positive bacteria process and release small peptides or “pheromones” that act as signals for the induction of adaptive traits including those involved in pathogenesis. One class of small signaling pheromones is the cyclic auto-inducing peptides (AIPs), which regulate expression of genes …

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Activation of human macrophage sodium channels regulates RNA processing to increase expression of the DNA repair protein PPP1R10

Chelsea R. White, Matthew Dungan, Michael D. Carrithers

Prior work demonstrated that a splice variant of SCN5A, a voltage-gated sodium channel gene, acts as a cytoplasmic sensor for viral dsRNA in human macrophages. Expression of this channel also polarizes macrophages to an anti-inflammatory phenotype in vitro and in vivo. Here …

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Defining the Role of a Putative Peptidase in Staphylococcus Aureus Quorum Sensing and Pathogenesis

Chelsea R. White

The pathogenic bacterium Staphylococcus aureus encounters a variety of immune cells that restrict bacterial growth and dissemination during infection. However, S. aureus counters these immune cell functions by producing myriad virulence factors that facilitate evasion of host defenses. Therefore, it is important …