Fecal transplantation and butyrate improve neuropathic pain, modify immune cell profile, and gene expression in the PNS of obese mice
Rattachement africain : us, Afrique du Sud. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Obesity affects over 2 billion people worldwide and is accompanied by peripheral neuropathy (PN) and an associated poorer quality of life. Despite high prevalence, the molecular mechanisms underlying the painful manifestations of PN are poorly understood, and therapies are restricted to use of painkillers or other drugs that do not address the underlying disease. Studies have demonstrated that the gut microbiome is linked to metabolic health and its alteration is associated with many diseases, including obesity. Pathologic changes to the gut microbiome have recently been linked to somatosensory pain, but any relationships between gut microbiome and PN in obesity have yet to be explored. Our data show that mice fed a Western diet developed indices of PN that were attenuated by concurrent fecal microbiome transplantation (FMT). In addition, we observed changes in expression of genes involved in lipid metabolism and calcium handling in cells of the peripheral nerve system (PNS). FMT also induced changes in the immune cell populations of the PNS. There was a correlation between an increase in the circulating short-chain fatty acid butyrate and pain improvement following FMT. Additionally, butyrate modulated gene expression and immune cells in the PNS. Circulating butyrate was also negatively correlated with distal pain in 29 participants with varied body mass index. Our data suggest that the metabolite butyrate, secreted by the gut microbiome, underlies some of the effects of FMT. Targeting the gut microbiome, butyrate, and its consequences may represent novel viable approaches to prevent or relieve obesity-associated neuropathies.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Fecal transplantation and butyrate improve neuropathic pain, modify immune cell profile, and gene expression in the PNS of obese mice
- Date Crossref
- 05/10/2020
- Éditeur
- National Academy of Sciences
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
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Loyola University Chicago pays non établi dans la noticeUniversité ou école supérieure
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University of Illinois Urbana-Champaign pays non établi dans la noticeUniversité ou école supérieure
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Illinois College Department of Cancer Biology and Pharmacology pays non établi dans la noticeUniversité ou école supérieure
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University of Illinois Chicago pays non établi dans la noticeUniversité ou école supérieure
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University of Cape Town Department of Human Biology University of Cape Town, Afrique du Sud (code pays fourni par la source)Université ou école supérieure
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University of California San Diego Department of Pathology pays non établi dans la noticeUniversité ou école supérieure
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Stritch School of Medicine Department of Cell and Molecular Physiology pays non établi dans la noticeUniversité ou école supérieure
Loyola University Chicago, University of Illinois Urbana-Champaign et Department of Cancer Biology and Pharmacology — Illinois College, avec 4 autres affiliations. Pays d’affiliation : Afrique du Sud.
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