Tyler M. Cook

GLP1 And Ghrelin Are Differentially Regulated In Female Rats In Response To A Meal Challenge

Paul A. Roberson, Ginger C. Johnson, Erin L. Hobday, Marguerite R. Kelher et autres

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Dysregulated glucagon signaling contributes to hypoglycemia after vertical sleeve gastrectomy in mice

Tyler M. Cook, Maigen Bethea, Silvania da Silva Teixeira, Carissa Birznieks et autres

OBJECTIVES: After bariatric surgery, many individuals experience debilitating bouts of hypoglycemia, termed post-bariatric hypoglycemia (PBH). Our mouse model of vertical sleeve gastrectomy (VSG) mimics key aspects of PBH in humans. As glucagon is a key element of the counterregulatory hormonal response to …

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The Role of Pancreatic Preproglucagon in Regulating Local Inflammation in Mice

Ellen Zalucha, Chelsea R. Hutch, Maigen Michelle Bethea, Tyler M. Cook et autres

Data suggest that both pancreatic and intestinally produced glucagon-like peptide-1 (GLP-1) increases in response to inflammation. Here, we set out to determine the tissue-specific function of increased GLP-1 during inflammatory stimuli. Using our innovative mouse model of tissue-specific Gcg (the gene that …

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Plasma GDF15 increases during hyperinsulinemic hypoglycemia in humans with post-bariatric hypoglycemia and after insulin exposure in mice

Rafael Ferraz-Bannitz, Lei Pei, Hanna Wang, BERKCAN OZTURK et autres

Post-bariatric hypoglycemia (PBH), characterized by excessive postprandial incretin and insulin secretion, is a common complication of bariatric surgery. Here, we investigate the relationship between PBH and growth differentiation factor 15 (GDF15) in individuals with PBH after Roux-en-Y gastric bypass (RYGB), post-RYGB individuals …

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Activity of Cardiomyocyte Type 3 Deiodinase After Myocardial Infarction Influences Cardiac Recovery in Females

Maigen Michelle Bethea, Tyler M. Cook, Preston Stafford, Leslie A. Knaub et autres

Thyroid hormone (TH) is essential for cardiovascular function, and women are disproportionately affected by TH disorders and experience worse outcomes following myocardial infarction (MI). However, the role of sex-specific TH regulation in post-MI cardiac recovery remains poorly understood. We investigated TH homeostasis …

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Weight loss reverses obesity-associated impairments in acute gastrointestinal stretch-induced suppression of food intake and glucose homeostasis

Maigen Michelle Bethea, Tyler M. Cook, Marwa Mommandi, Andrew McClennan et autres

OBJECTIVE: Chemical and mechanical signals from the gastrointestinal tract are critical for regulating satiety and glucose metabolism. While both nutrient sensing in the intestine and gastric distension has been well studied, the role of intestinal stretch in these metabolic processes remain unclear. …

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The role of the gut-brain axis in bariatric surgery

Tyler M. Cook, Maigen Michelle Bethea, Darleen A. Sandoval

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Insights into the neurobiology of weight loss after bariatric surgery and GLP-1R agonists

Tyler M. Cook, Kelly N. Z. Fuller, Darleen A. Sandoval

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The Advantage of Moving First in Amateur Online Chess

Tyler M. Cook

There is a long-held belief in the chess community that the player with the white pieces has an advantage in making the first move. This phenomenon has been observed repeatedly in over-the-board games between high-level players and professionals. However, less is known …

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Dual-action obesity drug rewires brain circuits for appetite

Tyler M. Cook, Darleen A. Sandoval

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SAT602 The Regulation Of Food Intake Via Gastrointestinal Receptors

Maigen Michelle Bethea, Silvania da Silva Teixeira, Tyler M. Cook, Marwa Mommandi et autres

Abstract Disclosure: M.M. Bethea: None. S. da Silva Teixeira: None. T.M. Cook: None. M. Mommandi: None. G. Nault: None. D. Sandoval: None. Obesity is a global pandemic characterized by excessive fat storage due to an imbalance in energy homeostasis. This metabolic imbalance …

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Fecal microbiome transplantation and tributyrin improves early cardiac dysfunction and modifies the BCAA metabolic pathway in a diet induced pre-HFpEF mouse model

Jomana Hatahet, Tyler M. Cook, Raiza R. Bonomo, Nadia Elshareif et autres

More than 50% of patients with heart failure present with heart failure with preserved ejection fraction (HFpEF), and 80% of them are overweight or obese. In this study we developed an obesity associated pre-HFpEF mouse model and showed an improvement in both …

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