Nadia Elshareif

A gut-adipose-nerve axis mediates inulin protection against Western diet-induced somatosensory dysfunction

Chaitanya K. Gavini, Laetitia Raux, Gwenaël Labouèbe, Emily Gornick et autres

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Dietary Fiber Improves Somatosensory Function in Western Diet–Fed Mice by Remodeling Adipose Immune Cells via FFAR2 Signaling

Chaitanya K. Gavini, Laetitia Raux, Gwenaël Labouèbe, Emily Gornick et autres

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Comparison of western diet-induced obesity and streptozotocin mouse models: insights into energy balance, somatosensory dysfunction, and cardiac autonomic neuropathy

Nadia Elshareif, Emily Gornick, Chaitanya K. Gavini, Grégory Aubert et autres

Metabolic disorders such as obesity and type 2 diabetes (T2D) are increasingly prevalent worldwide, necessitating a deeper comprehension of their underlying mechanisms. However, translating findings from animal research to human patients remains challenging. This study aimed to investigate the long-term effects of …

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Fecal microbiome transplantation and tributyrin improves early cardiac dysfunction and modifies the BCAA metabolic pathway in a diet induced pre-HFpEF mouse model

Jomana Hatahet, Tyler Cook, Raiza Bonomo, Nadia Elshareif et autres

More than 50% of patients with heart failure present with heart failure with preserved ejection fraction (HFpEF), and 80% of them are overweight or obese. In this study we developed an obesity associated pre-HFpEF mouse model and showed an improvement in both …

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LXR agonist modifies neuronal lipid homeostasis and decreases PGD2 in the dorsal root ganglia in western diet-fed mice

Nadia Elshareif, Chaitanya K. Gavini, Virginie Mansuy‐Aubert

The prevalence of peripheral neuropathy is high in diabetic and overweight populations. Chronic neuropathic pain, a symptom of peripheral neuropathy, is a major disabling symptom that leads to a poor quality of life. Glucose management for diabetic and prediabetic individuals often fail …

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LXR agonist improves peripheral neuropathy and modifies PNS immune cells in aged mice

Chaitanya K. Gavini, Nadia Elshareif, Grégory Aubert, Anand V. Germanwala et autres

BACKGROUND: Peripheral neuropathy is a common and progressive disorder in the elderly that interferes with daily activities. It is of importance to find efficient treatments to treat or delay this age-related neurodegeneration. Silencing macrophages by reducing foamy macrophages showed significant improvement of …

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LXR agonist Prevents Peripheral Neuropathy and modifies PNS immune cells in Aged Mice

Chaitanya K. Gavini, Nadia Elshareif, Anand V. Germanwala, Grégory Aubert et autres

Abstract Peripheral neuropathy is a common and progressive disorder in the elderly that interferes with daily activities and increases the risk of injury. It is of importance to find efficient treatments to treat or delay this age-related neurodegeneration. We previously demonstrated that …

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