Jomana Hatahet

Benign cardiac troponin I release induced by elevated beat rate is associated with membrane bleb formation

Jomana Hatahet, Hannah J. Nonarath, Mark T. Zafiratos, Geena Jasiek et autres

Cardiac troponin I (cTnI), a key regulatory protein of cardiomyocyte contraction, serves as a clinical biomarker for cellular necrosis. Measuring circulating cTnI in preclinical studies is used to assess cardiotoxicity of new chemical entities (NCEs) and gate their advancement into clinical trials. …

us (code pays fourni par la source)

Elevated beat rate induces benign cardiac troponin I release due to bleb formation in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)

Jomana Hatahet, Jessica Treadway, Mark T. Zafiratos, Aimee L. Bielinski et autres

us (code pays fourni par la source)

Polyamines mediate cellular energetics and lipid metabolism through mitochondrial respiration to facilitate virus replication

Yazmin E. Cruz-Pulido, Natalie J. LoMascolo, D.M. May, Jomana Hatahet et autres

Polyamines are critical cellular components that regulate a variety of processes, including translation, cell cycling, and nucleic acid metabolism. The polyamines, putrescine, spermidine, and spermine, are found abundantly within cells and are positively-charged at physiological pH. Polyamine metabolism is connected to distinct …

us (code pays fourni par la source)

Fecal microbiome transplantation and tributyrin improves early cardiac dysfunction and modifies the BCAA metabolic pathway in a diet induced pre-HFpEF mouse model

Jomana Hatahet, Tyler Cook, Raiza Bonomo, Nadia Elshareif et autres

More than 50% of patients with heart failure present with heart failure with preserved ejection fraction (HFpEF), and 80% of them are overweight or obese. In this study we developed an obesity associated pre-HFpEF mouse model and showed an improvement in both …

us, ch (code pays fourni par la source)

Monitoring of inflammation using novel biosensor mouse model reveals tissue- and sex-specific responses to Western diet

Sarah Talley, Raiza Bonomo, Chaitanya K. Gavini, Jomana Hatahet et autres

Obesity is an epidemic, and it is characterized by a state of low-grade systemic inflammation. A key component of inflammation is the activation of inflammasomes, multiprotein complexes that form in response to danger signals and that lead to activation of caspase-1. Previous …

us (code pays fourni par la source)

Live Monitoring of Inflammation Reveals Tissue and Sex-specific Responses to Western Diet and Butyrate treatment

Raiza Bonomo, Sarah Talley, Jomana Hatahet, Chaitanya K. Gavini et autres

Abstract Obesity is a current epidemic, affecting millions of individuals worldwide. Chronic obesity is characterized by a low-grade systemic inflammation besides not being a classic inflammatory disease. Many studies have tried to identify inflammatory insults dysregulated by a Westernized diet – consisted …

us (code pays fourni par la source)

Abstract MP228: The Role Of Gut Microbiome Secreted Short Chain Fatty Acids In The Development Of Heart Failure With Preserved Ejection Fraction HFpEF

Jomana Hatahet, Raiza Bonomo, Tyler Cook, Chelsea R. White et autres

More than 50% of patients with heart failure are diagnosed with heart failure with preserved ejection fraction (HFpEF), and 80% of them are obese. It is a prominent disease with no available treatments. It is characterized by diastolic dysfunction that involves increase …

us (code pays fourni par la source)