Accès ouvert
2026
article
OpenAlex
David S. Elias, Wonyoung Jo, Monica V. Talor, Camille Jaime et autres
mice to specifically delete IL-1 signaling in fibroblasts. This targeted deletion reduced total cardiac inflammation by 45%-specifically lowering monocytes, T cells, and NK cells-without affecting viral clearance. By confirming the presence of IFs in endomyocardial biopsies from human patients, we have shown …
us, cz
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Ina Sulkaj, Abdel Rahman Daoud, Daniela Čiháková, Monica Vladut Talor
Background: Myocarditis is an inflammatory heart disease often triggered by viral infections, autoimmunity, or environmental insults. While some patients recover, about 30% develop pathological cardiac remodeling, leading to dilated cardiomyopathy and heart failure. A hallmark of myocarditis is leukocyte infiltration, which disrupts …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Leyuan Ma, Alexander Hostetler, Duncan M. Morgan, Laura Maiorino et autres
Chimeric antigen receptor (CAR) T cell therapy effectively treats human cancer, but the loss of the antigen recognized by the CAR poses a major obstacle. We found that in vivo vaccine boosting of CAR T cells triggers the engagement of the endogenous …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Siawosh K. Eskandari, Hazim Allos, Jenelle M. Safadi, Ina Sulkaj et autres
In the transplant community, research efforts exploring endogenous alternatives to inducing tolerogenic allo-specific immune responses are much needed. In this regard, CD4 + FoxP3+ regulatory T cells (Tregs) are appealing candidates due to their intrinsic natural immunosuppressive qualities. To date, various homeostatic …
us, nl
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Leyuan Ma, Duncan M. Morgan, Ina Sulkaj, Parisa Yousefpour et autres
Abstract Chimeric Antigen Receptor (CAR) T-cell therapy can be effective in treating human cancer but loss of the antigen recognized by the CAR poses a major obstacle. Here, we report an approach for vaccine boosting CAR T-cells, which triggers engagement of the …
us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Siawosh K. Eskandari, Hazim Allos, Basmah S. Al Dulaijan, Gandolina Melhem et autres
Regulatory T cells (Tregs) have shown great promise as a means of cellular therapy in a multitude of allo- and auto-immune diseases—due in part to their immunosuppressive potency. Nevertheless, the clinical efficacy of human Tregsin patients has been limited by their poorin …
us, nl, de
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Siawosh K. Eskandari, Ina Sulkaj, Mariane B. Melo, Na Li et autres
Redox-sensitive cytokine cargoes backpacked on regulatory T cells promote local immune regulation in areas of rejection.
us, nl, ch
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Cheryl Brandenburg, Jean‐Jacques Soghomonian, Kunzhong Zhang, Ina Sulkaj et autres
Autism spectrum disorder (ASD) is behaviorally defined and diagnosed by delayed and/or impeded language, stereotyped repetitive behaviors and difficulties with social interactions. Additionally, there are disruptions in motor processing, which includes the intent to execute movements, interrupted/inhibited action chain sequences, impaired execution …
us
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
John Yongjoon Choi, Siawosh K. Eskandari, Songjie Cai, Ina Sulkaj et autres
Induction of longstanding immunologic tolerance is essential for survival of transplanted organs and tissues. Despite recent advances in immunosuppression protocols, allograft damage inflicted by antibody specific for donor organs continues to represent a major obstacle to graft survival. Here we report that …
us, nl
(code pays fourni par la source)