Yann Guérardel

A DltE–DltD–DltX interaction network regulates lipoteichoic acid D-alanylation and Lactiplantibacillus plantarum-mediated growth promotion in Drosophila

Renata C. Matos, Nikos Nikolopoulos, Quentin Perrier, Xavier Robert et autres

D-alanylation of teichoic acids is a conserved modification of Gram-positive bacterial cell envelopes that modulates resistance to environmental stresses and host interactions. While the cytosolic steps of this pathway are well characterized, the extracellular reactions responsible for transferring D-alanine onto teichoic acids …

fr, jp, us (code pays fourni par la source)

GlycoMsHelper: a simple and traceable workflow for Glycomic mass spectrometry data interpretation

Wei-Ze Kong, Yann Guérardel, Morihisa Fujita

Glycosylation is a fundamental post-translational and lipid modification that plays critical roles in diverse cellular processes. Although mass spectrometry (MS) is the primary platform for glycomic analysis, large-scale interpretation of glycomic MS data remains heavily dependent on expert manual annotation, creating a …

jp (code pays fourni par la source)

Cell wall arabinogalactan is responsible for Fungitell cross reactivity in nocardiosis

Christophe Mariller, Pascal Letowski, Wei‐Ting Chang, Todd L. Lowary et autres

Nocardiosis is a serious infection in immunosuppressed patients, especially transplant recipients. The slow-growing phenotype of the bacterium and the variety of symptoms complicate diagnosis and delay antimicrobial therapy, resulting in high mortality rates despite effective treatments. A further complication is that some …

fr, tw (code pays fourni par la source)

The glycocalyx of Lacticaseibacillus paracasei NPB01 presents two different rhamnose-rich polysaccharides with non-equivalent immunomodulating activities

Samantha Armiento, Franca Oglio, Antonio Masino, Xavier Trivelli et autres

Lacticaseibacillus paracasei cell wall presents two capsular polysaccharides, CPS-1 and CPS-2, and a teichoic acid. CPS-1 is novel and it presents a branched heptasaccharide repeating unit, with the sequence →6)-α-d-Gal-(1→3)-β-l-Rha-(1→4)-β-d-Glc-(1→3)-α-d-GlcNAc-(1→2)-β-d-Glc-(1→6)-β-d-Glc-(1→ in the linear part to which a β-l-Rha is attached to O-4 …

it, fr (code pays fourni par la source)

Uncommon N-Glycan Structures in Anhydrobiotic Tardigrades

Hirokazu Yagi, Taiki Saito, Shih-Yun Guu, Nao Yamakawa et autres

We characterized the N-glycosylation profiles of anhydrobiotic tardigrades, Ramazzottius varieornatus and Hypsibius exemplaris, identifying high-mannose, paucimannose, and complex-type oligosaccharides, while hybrid-type glycans were undetectable. Notably, paucimannose-type oligosaccharides accounted for 39% of the N-glycans in R. varieornatus and 17% in H. exemplaris, with …

jp, tw, fr (code pays fourni par la source)

A glycosylated lipooctapeptide promotes uptake and growth of Mycobacterium abscessus in the host

Louis-David Leclercq, Vincent Le Moigne, Wassim Daher, Mélanie Cortès et autres

Pathogenic mycobacteria produce a wide array of lipids which participate in host cell interactions and virulence. While some of these are conserved across all mycobacteria, others, like glycopeptidolipids (GPL), are restricted to a few species. Mycobacterium abscessus, an emerging rapid-growing pathogen, transitions …

fr, jp (code pays fourni par la source)

Anemonefish use sialic acid metabolism as Trojan horse to avoid giant sea anemone stinging

Natacha Roux, Clément Delannoy, Shin‐Yi Yu, Saori Miura et autres

BACKGROUND: Anemonefish association with sea anemones is a prime example of mutualistic symbiosis. These fish live inside the sea anemone, benefitting from the protection of its toxic nematocysts, and in return, protect the anemone from its own predators. How anemonefish manage to …

jp, fr, tw (code pays fourni par la source)

Biochemical characterization of the Escherichia coli surfaceome: a focus on type I fimbriae and flagella

Devon Kavanaugh, Adeline Sivignon, Yannick Rossez, Zina Chouit et autres

The Escherichia coli surfaceome consists mainly of the large surface organelles expressed by the organism to navigate and interact with the surrounding environment. The current study focuses on type I fimbriae and flagella. These large polymeric surface organelles are composed of hundreds …

fr (code pays fourni par la source)

Glycan-mediated adhesion mechanisms in antibiotic-resistant bacteria

Clara Dessenne, Christophe Mariller, Olivier Vidal, Isabelle Huvent et autres

Bacterial adhesins play a central role in host-pathogen interactions, with many specifically targeting glycans to mediate bacterial colonization, influence infection dynamics, and evade host immune responses. In this review, we focus on bacterial pathogens identified by the World Health Organization as critical …

fr, jp (code pays fourni par la source)

Mucins and Bacterial Interactions

Yannick Rossez, Renaud Léonard, Olivier Vidal, Zina Chouit et autres

fr (code pays fourni par la source)

A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging

Charlène Iltis, Iryna Moskalevska, Antoine Debiesse, Laetitia Seguin et autres

Abstract Although senescent cells can be eliminated by the immune system, they tend to accumulate with age in various tissues. Here we show that senescent cells can evade immune clearance by natural killer (NK) cells by upregulating the expression of the disialylated …

fr, jp (code pays fourni par la source)

Ganglioside expression delineates human mesenchymal stem/stromal cell populations derived from different tissue sources

Sophie Groux‐Degroote, Kyle C. Martin, Bernadette Coddeville, Yann Guérardel et autres

fr, us, jp (code pays fourni par la source)