Renaud Léonard

Hydrogen metabolism shapes gut microbiome into health-associated configurations

Mathilde Sola, Anne Hiol, Giacomo Viatli, Sébastien Fromentin et autres

Abstract The human gut microbiome exhibits reproducible configurations, yet the ecological forces connecting them to health remain unclear. Here, using enterosignature-based stratification of 5,170 individuals from the Le French Gut cohort, we identified hydrogen disposal as a key determinant of population-scale microbiome …

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Interaction between the apicomplexan parasite Cryptosporidium parvum and host intestinal mucus

Julie Tottey, Alix Sausset, Soana Mohamed, Julien Pichon et autres

National audience

Screening of the transcriptome, mucinome, and O‐/N‐glycans of the intestinal goblet cell model HT29‐MTX during zinc deficiency

Christoph Schüßler, Nara Chung, Renaud Léonard, Heike Sprenger et autres

Abstract Zinc deficiency is a global health problem affecting approximately one billion people and is associated with serious health consequences, including impaired immune function and an increased susceptibility to infections and inflammation [1,2]. It is also linked to disrupted intestinal homeostasis and …

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A Western-style diet shapes the gut and liver responses to low-dose, fit-for-purpose polystyrene nanoplastics in mice

Chloé Liebgott, Sophie Miguel, Valérie Bézirard, Catherine Beaufrand et autres

Subchronic exposure to fit-for-purpose polystyrene nanoplastics impairs gut and liver health at low doses with non-monotonic effects in a diet-dependent manner.

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Author response for "A Western-style diet shapes the gut and liver responses to low-dose, fit-for-purpose polystyrene nanoplastics in mice"

Chloé Liebgott, Sophie Miguel, Valérie Bézirard, Catherine Beaufrand et autres

Author response for "A Western-style diet shapes the gut and liver responses to low-dose, fit-for-purpose polystyrene nanoplastics in mice"

Chloé Liebgott, Sophie Miguel, Valérie Bézirard, Catherine Beaufrand et autres

Metaproteomics in the One Health framework for unraveling microbial effectors in microbiomes

Robert Heyer, Maximilian Wolf, Dirk Benndorf, Sergio Uzzau et autres

Abstract One Health seeks to integrate and balance the health of humans, animals, and environmental systems, which are intricately linked through microbiomes. These microbial communities exchange microbes and genes, influencing not only human and animal health but also key environmental, agricultural, and …

de, it, fr, nl, be, es, us, lu (code pays fourni par la source)

Metaproteomics in the One Health Framework for Unraveling Microbial Effectors in Microbiomes

Robert Heyer, Maximilian Wolf, Dirk Benndorf, Sergio Uzzau et autres

One Health seeks to integrate and balance the health of humans, animals, and environmental systems. These three spheres are intricately interconnected through microbiomes, which are universally present and exchange microbes and genes, influencing not only human and animal health but also key …

de, it, fr, nl, be, es, us, lu (code pays fourni par la source)

Mucins and Bacterial Interactions

Yannick Rossez, Renaud Léonard, Olivier Vidal, Zina Chouit et autres

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Unraveling Microbial Effectors: Metaproteomics in the One Health Framework

Robert Heyer, Maximilian Wolf, Dirk Benndorf, Sergio Uzzau et autres

One Health seeks to integrate and balance the health of humans, animals, and environmental systems. These three spheres are intricately interconnected through microbiomes, which are universally present and exchange microbes and genes, influencing not only human and animal health but also key …

de, it, fr, nl, be, es, us, lu (code pays fourni par la source)

Induction of intercrypt goblet cells upon bacterial infection: a promising therapeutic target to restore the mucosal barrier

Renaud Léonard, Ewa Pasquereau-Kotula, Edwige Madec, Benjamin Marsac et autres

Intestinal mucins play a crucial role in the mucosal barrier, serving as the body’s initial defense against microorganisms. However, how the host regulates the secretion and glycosylation of these mucins in response to bacterial invasion remains unclear. Our study demonstrates that when …

fr (code pays fourni par la source)

Induction of intercrypt goblet cells upon bacterial infection

Renaud Léonard, Ewa Pasquereau-Kotula, Edwige Madec, Benjamin Marsac et autres

Summary Intestinal mucins play a crucial role in the mucosal barrier, serving as the body’s initial defense against microorganisms. However, how the host regulates the secretion and glycosylation of these mucins in response to bacterial invasion remains unclear. Our study demonstrates that …

fr (code pays fourni par la source)