Accès ouvert
2025
article
OpenAlex
Chunsheng Jin, Jon Lundstrøm, Carmen R. Cori, Shih-Yun Guu et autres
Milk oligosaccharides are crucial for neonatal development and health in mammals. Yet most milk research focuses on humans, or on domesticated mammals that are poor in milk oligosaccharide complexity. Here, we perform an exhaustive mass spectrometry-driven structural characterization of milk oligosaccharides in …
se, ch, tw, gb
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Accès ouvert
2025
article
OpenAlex
Chelsea May Brown, Satchal K. Erramilli, Yi‐Chia Su, Shih-Yun Guu et autres
The global challenge of tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is compounded by the emergence of drug-resistant strains. A critical factor in Mtb's pathogenicity is its intricate cell envelope, which acts as a formidable barrier against immune defences and pharmacological interventions. Central …
us, nl, gb, tw, ca, pt
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Accès ouvert
2025
article
OpenAlex
Hirokazu Yagi, Taiki Saito, Shih-Yun Guu, Nao Yamakawa et autres
We characterized the N-glycosylation profiles of anhydrobiotic tardigrades, Ramazzottius varieornatus and Hypsibius exemplaris, identifying high-mannose, paucimannose, and complex-type oligosaccharides, while hybrid-type glycans were undetectable. Notably, paucimannose-type oligosaccharides accounted for 39% of the N-glycans in R. varieornatus and 17% in H. exemplaris, with …
jp, tw, fr
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Accès ouvert
2025
preprint
OpenAlex
Chunsheng Jin, Jon Lundstrøm, Carmen R. Cori, Shih-Yun Guu et autres
Abstract Breast milk oligosaccharides are crucial for neonatal development and health. Yet most milk research focuses on humans, or domesticated mammals that are historically poor in milk oligosaccharide complexity. Here, we perform an exhaustive mass spectrometry-driven structural characterization of milk oligosaccharides in …
se, ch, tw, it
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Pierre‐André Gilormini, V. Narasimharao Thota, Anthony Fers-Lidou, Roger A. Ashmus et autres
The fucosylation of glycoproteins regulates diverse physiological processes. Inhibitors that can control cellular levels of protein fucosylation have consequently emerged as being of high interest. One area where inhibitors of fucosylation have gained significant attention is in the production of afucosylated antibodies, …
ca, tw, us
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Accès ouvert
2023
article
OpenAlex
Audrey Auger, Shin‐Yi Yu, Shih-Yun Guu, Agnès Quéméner et autres
Noroviruses, the major cause of acute viral gastroenteritis, are known to bind to histo-blood group antigens (HBGAs), including ABH groups and Lewis-type epitopes, which decorate the surface of erythrocytes and epithelial cells of their host tissues. The biosynthesis of these antigens is …
fr, tw, jp
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Accès ouvert
2020
article
OpenAlex
Hsuan‐Hsuan Lu, Shu‐Yung Lin, Rueyhung Roc Weng, Yi‐Hsiu Juan et autres
BACKGROUND: Aberrant fucosylation plays a critical role in lung cancer progression. Nevertheless, the key fucosyltransferase with prognostic significance in lung cancer patients, the enzyme's intracellular targets, and complex molecular mechanisms underlying lung cancer metastasis remain incompletely understood. METHODS: We performed a large-scale …
tw
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2018
article
OpenAlex
Chu‐Wei Kuo, Shih-Yun Guu, Kay‐Hooi Khoo
High sensitivity identification of sulfated glycans carried on specific sites of glycoproteins is an important requisite for investigation of molecular recognition events involved in diverse biological processes. However, aiming for resolving site-specific glycosylation of sulfated glycopeptides by direct LC-MS 2 sequencing is …
tw
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