Khalifa El Malki

Hepatosplenisches T-Zell-Lymphom: wichtige Differentialdiagnose zu einer Hepatitis

Beate Katharina Straub, Larissa Seidmann, Khalifa El Malki, Wolfram Klapper et autres

de (code pays fourni par la source)

Ganglioside Profiling Uncovers Distinct Patterns in High-Risk Neuroblastoma

Claudia Paret, Arthur Wingerter, Larissa Seidmann, Arsenij Ustjanzew et autres

High-risk (HR) neuroblastoma (NBL) patients often receive standardized treatment despite wide variations in clinical outcomes, underscoring the need for improved stratification tools. A distinguishing feature of NBL is the patient-specific expression of gangliosides (GGs), particularly GD2, which may serve as biomarkers. We …

de, it (code pays fourni par la source)

The Chimeric Antigen Receptor T Cell Target Claudin 6 Is a Marker for Early Organ-Specific Epithelial Progenitors and Is Expressed in Some Pediatric Solid Tumor Entities

Larissa Seidmann, Arthur Wingerter, Marie Oliver Metzig, Angelina Bornas et autres

Background/Objectives: The oncofetal membrane protein Claudin 6 (CLDN6) is an attractive target for T cell-based therapies. There is a lack of detailed analyses on the age-dependent expression of CLDN6 in normal tissues is lacking, which limits the expansion of CLDN6 CAR-T cell …

de (code pays fourni par la source)

Glucosylceramide Synthase Inhibitors Induce Ceramide Accumulation and Sensitize H3K27 Mutant Diffuse Midline Glioma to Irradiation

Khalifa El Malki, Pia Charlotte Wehling, Francesca Alt, Roger Sandhoff et autres

H3K27M mutant (mut) diffuse midline glioma (DMG) is a lethal cancer with no effective cure. The glycosphingolipids (GSL) metabolism is altered in these tumors and could be exploited to develop new therapies. We tested the effect of the glucosylceramide synthase inhibitors (GSI) …

de, lu (code pays fourni par la source)

Analysis of RBP expression and binding sites identifies PTBP1 as a regulator of CD19 expression in B-ALL

Nicole Ziegler, Mariela Cortés-López, Francesca Alt, Maximilian Sprang et autres

Despite massive improvements in the treatment of B-ALL through CART-19 immunotherapy, a large number of patients suffer a relapse due to loss of the targeted epitope. Mutations in the CD19 locus and aberrant splicing events are known to account for the absence …

de, bg (code pays fourni par la source)

IL-17 Signaling in Keratinocytes Orchestrates the Defense against Staphylococcus aureus Skin Infection

Sonja Moos, Tommy Regen, Florian Wanke, Yizhu Tian et autres

de, ch (code pays fourni par la source)

GD2 Expression in Medulloblastoma and Neuroblastoma for Personalized Immunotherapy: A Matter of Subtype

Claudia Paret, Arsenij Ustjanzew, Sara Ersali, Larissa Seidmann et autres

Neuroblastoma (NBL) and medulloblastoma (MB) are aggressive pediatric cancers which can benefit from therapies targeting gangliosides. Therefore, we compared the ganglioside profile of 9 MB and 14 NBL samples by thin layer chromatography and mass spectrometry. NBL had the highest expression of …

de, lu (code pays fourni par la source)

DIPG-43. Glucosylceramide synthase inhibitors induce ceramide accumulation and sensitise H3K27 Mutant Diffuse midline Glioma to irradiation

Claudia Paret, Roger Sandhoff, Sebastian Zahnreich, Pia Charlotte Wehling et autres

Abstract BACKGROUND AND AIMS: Glycosphingolipids (GSL) are amphipathic lipids particularly abundant in the brain where their amount and expression patterns change drastically during the embryonic to postnatal stages and during tumorigenesis. The biosynthesis of GSL begins with the formation of glucosylceramide from …

de (code pays fourni par la source)

Deregulation in binding and expression of RNA binding proteins as a mechanism of CD19-negative B-ALL

Nicole Ziegler, Mariela Cortés-López, Francesca Alt, Maximilian Sprang et autres

de (code pays fourni par la source)

Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients

Matteo Winker, Sandra Stössel, Marie Astrid Neu, Nadine Lehmann et autres

While exercise and physical activity have been suggested to reduce mortality and symptoms in cancer, knowledge on these associations in patients with childhood cancer (CCPs) is sparse. Anti-inflammatory properties of exercise might mediate these beneficial effects. We investigated the influence of exercise …

de (code pays fourni par la source)

Identification of an Immunogenic Medulloblastoma-Specific Fusion Involving EPC2 and GULP1

Claudia Paret, Nadine Lehmann, Hannah G. Bender, Maximilian Sprang et autres

Medulloblastoma is the most common malignant brain tumor in children. Immunotherapy is yet to demonstrate dramatic results in medulloblastoma, one reason being the low rate of mutations creating new antigens in this entity. In tumors with low mutational burden, gene fusions may …

de (code pays fourni par la source)

HGG-03. THE GLYCOSPHINGOLIPIDS METABOLISM IS A NOVEL TARGET IN H3K27M-MUTANT DIFFUSE MIDLINE GLIOMA

Claudia Paret, Roger Sandhoff, Khalifa El Malki, Katrin B. M. Frauenknecht et autres

Abstract H3K27M-mutant diffuse midline glioma (H3K27M-mutant DMG) is a rare malignant brain tumour entity in children and adults with a median overall survival of around 12 months. Genomic and proteomic analysis may help to identify new target structures, however not all relevant …

de (code pays fourni par la source)