Carmen Sofica Tatu

Microbiota-Driven Immune Dysregulation Along the Gut–Lung–Vascular Axis in Asthma and Atherosclerosis

Elena-Larisa Zimbru, Răzvan-Ionuț Zimbru, Florina-Maria Bojin, Sorin Dan Chiriac et autres

Background: Asthma and atherosclerosis frequently coexist in clinical populations and share convergent immunometabolic pathways amplified by gut microbial dysbiosis. We propose the gut–lung–vascular axis as a unifying mechanistic framework connecting epithelial and endothelial inflammation providing a foundation for understanding shared inflammatory mechanisms …

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Connecting the Dots: How MicroRNAs Link Asthma and Atherosclerosis

Răzvan-Ionuț Zimbru, Elena-Larisa Zimbru, Florina Maria Bojin, Laura Haidar et autres

Asthma and atherosclerosis are chronic conditions with distinct pathophysiologies, but overlapping inflammatory mechanisms that suggest a potential common regulatory framework. MicroRNAs (miRNAs), small non-coding RNA molecules that modulate gene expression post-transcriptionally, could be key players in linking these disorders. This review outlines …

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Vitamins, Coenzyme Q10, and Antioxidant Strategies to Improve Oocyte Quality in Women with Gynecological Cancers: A Comprehensive Review

Isaic Alexandru, Daciana Nistor, Alexandru Cătălin Motofelea, Bianca-Astrid Cadar et autres

BACKGROUND: Gynecological cancers, including ovarian, cervical, and endometrial cancers, significantly affect both survival and reproductive health in women. Cancer treatments such as chemotherapy and radiotherapy can impair ovarian function, reducing oocyte quality and fertility potential. OBJECTIVE: This review aims to evaluate how …

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A Custom-Made Electronic Dynamometer for Evaluation of Peak Ankle Torque after COVID-19

Iulia Iovanca Drăgoi, Florina Georgeta Popescu, Teodor Petriţa, Florin Alexa et autres

The negative effects of SARS-CoV-2 infection on the musculoskeletal system include symptoms of fatigue and sarcopenia. The aim of this study is to assess the impact of COVID-19 on foot muscle strength and evaluate the reproducibility of peak ankle torque measurements in …

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A Custom-Made Lower Limb Dynamometer for Assessing Ankle Joint Torque in Humans: Calibration and Measurement Procedures

Iulia Iovanca Drăgoi, Florina Georgeta Popescu, Teodor Petriţa, Romulus Fabian Tatu et autres

Custom-made dynamometry was shown to objectively analyze human muscle strength around the ankle joint with accuracy, easy portability and low costs. This paper describes the full method of calibration and measurement setup and the measurement procedure when capturing ankle torque for establishing …

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A 3D Bioprinted Human Meniscus Shape Enriched with Mesenchymal Cells

Mihai Hurmuz, Mihai Edmond Ionac, Carmen Sofica Tatu, Daniela Anca Puscasiu et autres

Background and objectives: Regenerative medicine, with its massive development over the years, has the potential to solve some of the most problematic medical issues, such as functional organ transplantation. The aim of this study was to create a human meniscal shape 3D-printed …

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Essential Oils and Plant Extracts with Antibacterial and Anti-Biofilm Activities against Multidrug Resistant Bacteria

Carmen Sofica Tatu, Gabriela Tănasie, Camelia Tulcan, Cristina Mirabela Gaspar et autres

Introduction Antimicrobial resistance became a major worldwide threat. Research have been focused recently on the reassessment of natural products as molecules with high biological and chemical potential. We aimed to study the efficacy of several extracts and essential oils with less known …

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Hydrogel Based Biomeniscus 3D Printed Seeded with Human Adipose Derived Mesenchymal Stem cells

Mihai Hurmuz, Mihai Edmond Ionac, Carmen Sofica Tatu, Carmen Puscasiu et autres

Anterior cruciate ligament reconstrucion is one of the most performed procedures in today’s Orthopedic elective surgeries. Despite the high number there is a relative low infection rate reported between 0.001 to 1.1%. Early diagnostic is especially important as the main goal is …

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Adhesion and Secretory Profile of Mesenchymal Stem Cells Upon Contact with Some Biomaterials

Carmen Sofica Tatu, Carmen Bunu Panaitescu, Laura Marusciac, Alina Maria Șișu et autres

The aim of this study was to investigate the adhesion and secretory profile of mesenchymal stem cells in contact with biomaterials used in the field of tissue engineering. Mesenchymal stem cells obtained from lipoaspirate and two biomaterials were used: anodized titanium plates …

In Vitro Effects of Biomaterials on Mesenchymal Stem Cells Viability and Proliferation

Gabriela Tănasie, Florina Maria Bojin, Romulus Fabian Tatu, Alina Maria Șișu et autres

Mesenchymal stem cells (MSCs) are increasingly being used in regenerative medicine to repair various tissue types. This study aimed to assess changes in MSCs properties as a result of their interaction with two biomaterials in order to evaluate their in vitro compatibility. …

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Injected and Colouring Substances Largely Used in Processing Microscopic Anatomical Structures

Sorin Lucian Bolintineanu, Daniela Anca Puscasiu, Codruţa Ileana Petrescu, Romulus Fabian Tatu et autres

There are many fixing and colouring substances largely used in the anatomy laboratories, for teaching purpose. We have injected 22 adult human hearts, removed from the cadavers belonging to the Anatomy and Embryology Department. On 6 specimens we have followed the embryologic …

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The Contribution of Histochemical and Immunohistochemical Techniques in Assessing the Proliferative Capacity and Prognosis for Renal Cell Carcinoma

Daniela Anca Puscasiu, Gabriela Tănasie, Marius Georgescu, Romulus Fabian Tatu et autres

The drive to prolong life and to improve life quality in patients suffering from cancer forms of any kind means that, aside from the necessary treatment, prognostic evaluations are needed. In our present study we included 63 patients with renal cell carcinoma. …