Florina Maria Bojin

Systemic Melanoma Therapy in Patients with Pre-Existing Heart Failure: An HF-Centered Decision Framework and Critical Narrative Review

Daniela-Vasilica Serban, Diana-Maria Mateescu, Daniela Crainic, Nina Ivanovic et autres

Background/Objectives: General cardio-oncology guidance describes cardiovascular toxicity from BRAF/MEK inhibitors and immune checkpoint inhibitors (ICIs), but it does not resolve how treatment decisions should change when heart failure (HF) is already present. This critical narrative review separates direct HF-specific evidence from indirect …

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Empagliflozin Protects Against Doxorubicin Cardiotoxicity: Integrative Assessment of Cardiac Kinetics and Electrophysiology Using Machine Learning in a Rat Model

Iacob-Daniel Goje, Valentin Laurentiu Ordodi, Florina Maria Bojin, Greta Ionela Barbulescu et autres

Background/Objectives: Anthracycline-induced cardiotoxicity remains a major challenge in cancer treatment, and researchers are showing interest in artificial intelligence (AI) to improve the prediction and detection of cancer therapy-related cardiac dysfunction (CTRCD). Current surveillance strategies rely mainly on left ventricular ejection fraction and, …

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Innovative Therapy with Stem Cell-Derived Extracellular Vesicles on Cardiac Hypertrophy in an Animal Model of Atherosclerosis; Elucidation of the Molecular Mechanisms Involved in the Repair Process

Alexandra Vîlcu, Ioana Karla Comariţa, Alina Liliana Constantin, Nicoleta Alexandru et autres

(1) Background: The present study investigated the effects of extracellular vesicles (EVs), derived from adipose tissue stem cells (ADSCs) and bone marrow mesenchymal stem cells (BMMSCs), on atherosclerosis-associated cardiac hypertrophy. (2) Methodology: The experiments were performed on hamsters divided into the following …

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Microengineered Breast Cancer Models: Shaping the Future of Personalized Oncology

Tudor-Alexandru Popoiu, Anca Maria Cîmpean, Florina Maria Bojin, Simona Cerbu et autres

Background: Breast cancer remains the most prevalent malignancy in women worldwide, characterized by remarkable genetic, molecular, and clinical heterogeneity. Traditional preclinical models have significantly advanced our understanding of tumor biology, yet consistently fall short in recapitulating the complexity of the human tumor …

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Anti-Her2 CAR-NK92 Cells and Their Exosomes: Generation, Characterization, and Selective Cytotoxicity Against Her2-Positive Tumor Cells

Alexandru Tîrziu, Florina Maria Bojin, Oana-Isabella Gavriliuc, Maria Roxana Buzan et autres

Chimeric antigen receptor (CAR)-engineered NK cells are a promising approach for targeted immunotherapy in Her2-positive cancers. This study aimed to generate anti-Her2 CAR-NK92 cells, to evaluate their selective cytotoxicity against Her2-positive cancer cells, and to isolate and characterize their released exosomes. NK92 …

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Doxorubicin-Induced Cardiotoxicity and the Emerging Role of SGLT2 Inhibitors: From Glycemic Control to Cardio-Oncology

Iacob-Daniel Goje, Greta Ionela Barbulescu, Valentin Laurentiu Ordodi, Valentina Gabriela Ciobotaru et autres

Cancer remains the second leading cause of death worldwide. Doxorubicin (DOX) is a cornerstone of hematologic malignancy treatment, but it is limited by its dose-dependent cardiotoxicity, leading to systolic and diastolic cardiac dysfunction and, ultimately, dilated hypokinetic cardiomyopathy. Cardio-oncology has emerged as …

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Connecting the Dots: How MicroRNAs Link Asthma and Atherosclerosis

Răzvan-Ionuț Zimbru, Elena-Larisa Zimbru, Florina Maria Bojin, Laura Haidar et autres

Asthma and atherosclerosis are chronic conditions with distinct pathophysiologies, but overlapping inflammatory mechanisms that suggest a potential common regulatory framework. MicroRNAs (miRNAs), small non-coding RNA molecules that modulate gene expression post-transcriptionally, could be key players in linking these disorders. This review outlines …

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Breaking Barriers: The Detrimental Effects of Combined Ragweed and House Dust Mite Allergen Extract Exposure on the Bronchial Epithelium

Răzvan-Ionuț Zimbru, Manuela Grijincu, Gabriela Tănasie, Elena-Larisa Zimbru et autres

(1) Background: Respiratory allergens, particularly ragweed (RW) pollen and house dust mites (HDMs), are major triggers of respiratory inflammation and allergic diseases. This study investigated the impact of single- versus combined-allergen exposure on the barrier function of normal human bronchial epithelial (NHBE) …

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Exploring CAR-PBMCs: A Novel Strategy Against EGFR-Positive Tumor Cells

Alexandru Tîrziu, Oana-Isabella Gavriliuc, Florina Maria Bojin, Virgil Păunescu

Background: Chimeric antigen receptor (CAR) T cell therapy has shown significant promise in treating hematological malignancies, yet its application in solid tumors, particularly those expressing the epidermal growth factor receptor (EGFR), remains limited. This study investigates the potential of CAR-engineered peripheral blood …

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Rosuvastatin Attenuates Vascular Dysfunction Induced by High-Fructose Diets and Allergic Asthma in Rats

Elena-Larisa Zimbru, Răzvan-Ionuț Zimbru, Valentin-Laurențiu Ordodi, Florina Maria Bojin et autres

BACKGROUND: A growing body of evidence links a high-fructose diet (HFrD) to metabolic disturbances, including inflammation, dyslipidemia, insulin resistance and also endothelial dysfunction, yet its role in allergic asthma remains underexplored. Considering that obesity and hypercholesterolemia exacerbate asthma by promoting systemic inflammation, …

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Buforin-Derived Synthetic Peptides with Potential Application in Medicine

Dana Maria Copolovici, Cristian Moisă, Andreea Ioana Lupitu, Oana Isabella Gavriliuc et autres

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The Impact of High-Fructose Diet and Co-Sensitization to House Dust Mites and Ragweed Pollen on the Modulation of Airway Reactivity and Serum Biomarkers in Rats

Răzvan-Ionuț Zimbru, Elena-Larisa Zimbru, Valentin-Laurențiu Ordodi, Florina Maria Bojin et autres

The topic of ragweed pollen (RW) versus house dust mites (HDMs) has often been deliberated, but the increasing incidence of co-sensitization between them has been scarcely addressed. Utilizing Sprague Dawley rats, we explored the effects of co-sensitization with the combination of HDMs …

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