Vitamins, Coenzyme Q10, and Antioxidant Strategies to Improve Oocyte Quality in Women with Gynecological Cancers: A Comprehensive Review
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Le résumé fourni par la source
BACKGROUND: Gynecological cancers, including ovarian, cervical, and endometrial cancers, significantly affect both survival and reproductive health in women. Cancer treatments such as chemotherapy and radiotherapy can impair ovarian function, reducing oocyte quality and fertility potential. OBJECTIVE: This review aims to evaluate how vitamins and antioxidants can enhance fertility and fertility preservation outcomes for women diagnosed with gynecological cancers, particularly in the context of assisted reproductive technologies (ART). Standard treatments for these cancers, including hysterectomy, bilateral salpingo-oophorectomy, radiation, and chemotherapy, often compromise ovarian function and oocyte quality. This review focuses on the potential role of these interventions in improving oocyte quality, thereby supporting successful fertility preservation and ART outcomes. METHODS: A comprehensive narrative review of the current literature was conducted, examining the effects of vitamins A, C, D3, E, and Coenzyme Q10 on oocyte quality, particularly in the context of oxidative stress and inflammation induced by cancer and its treatments. RESULTS: The evidence suggests that certain vitamins and antioxidants may mitigate oxidative damage and enhance oocyte quality. Vitamin A supports cumulus-oocyte complex integrity, while vitamins C and E act as potent antioxidants, reducing oxidative stress in ovarian tissues. Vitamin D3 enhances ovarian reserve markers and modulates inflammatory cytokines. Coenzyme Q10 improves mitochondrial function and reduces DNA damage, increasing oocyte viability and fertilization potential. CONCLUSIONS: The incorporation of specific vitamins and antioxidants into fertility preservation strategies may enhance oocyte quality in women with gynecological cancers. Although the preliminary findings are promising, further research is needed to determine optimal dosages and establish standardized protocols for clinical use.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Vitamins, Coenzyme Q10, and Antioxidant Strategies to Improve Oocyte Quality in Women with Gynecological Cancers: A Comprehensive Review
- Date Crossref
- 19/12/2024
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Victor Babeș University of Medicine and Pharmacy Timișoara pays non établi dans la noticeUniversité ou école supérieure
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Babeș-Bolyai University Interdisciplinary Research Institute in Bio-Nano-Sciences pays non établi dans la noticeUniversité ou école supérieure
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Iuliu Hațieganu University of Medicine and Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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University of Oradea pays non établi dans la noticeUniversité ou école supérieure
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“Victor Babes” University of Medicine and Pharmacy Timisoara Department of General Surgery pays non établi dans la noticeUniversité ou école supérieure
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"Victor Babes" University of Medicine and Pharmacy Timisoara Department of General Surgery pays non établi dans la noticeUniversité ou école supérieure
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Centre for Gene and Cellular Therapies in Cancer pays non établi dans la noticeInstitution
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Faculty of Medicine Center for Molecular Research in Nephrology and Vascular Disease pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Physics pays non établi dans la noticeUniversité ou école supérieure
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University of Medicine and Pharmacy “Iuliu Hațieganu” Department of Molecular Sciences pays non établi dans la noticeUniversité ou école supérieure
Victor Babeș University of Medicine and Pharmacy Timișoara, Interdisciplinary Research Institute in Bio-Nano-Sciences — Babeș-Bolyai University et Iuliu Hațieganu University of Medicine and Pharmacy, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.