Accès ouvert
2026
article
OpenAlex
Tobias M. Defesche, Thomas Koudstaal, Marjan A. Versnel, Odilia B.J. Corneth et autres
Interstitial lung disease (ILD) underlies morbidity and mortality in connective tissue diseases (CTDs) such as systemic sclerosis. ILD encompasses a range of inflammatory and fibrotic pneumopathies, some of which manifest progressive characteristics. Up to 40% of ILDs are progressive, marked by radiologic …
nl
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Accès ouvert
2025
article
OpenAlex
Bart Humer, Julia C. Berentschot, Cornelia G van Helden-Meeuwsen, L. Martine Bek et autres
PURPOSE: Long COVID (LC) is a long-term debilitating disease of which the exact pathophysiology is unknown. A dysregulated immune response resulting in hyperresponsive immune cells is hypothesized as a key mechanism in the development of LC. Several studies suggest that acute infections …
nl
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Accès ouvert
2025
article
OpenAlex
Marina Barguil Macêdo, Mohamed Javad Wahadat, Albin Björk, Sylvia S M Kamphuis et autres
OBJECTIVES: Mitochondria are prominent antigenic sources, capable of triggering IFN-induced inflammatory pathways in SLE. Recent studies suggest presence of AMA in LN patients with adult-onset SLE. Whether AMA reflect disease activity in childhood-onset SLE (cSLE) remains unexplored. Here, we present inaugural data …
us, nl, se
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Accès ouvert
2025
article
OpenAlex
Takayuki Shibahara, Burcu Temizoz, Shiori Egashira, Koji Hosomi et autres
Aberrant activation of the stimulator of interferon genes (STING) pathway is a hallmark of autoinflammatory disorders such as STING-associated vasculopathy with onset in infancy (SAVI), characterized by systemic inflammation affecting blood vessels, skin, and lungs. Despite its clinical significance, the mechanisms linking …
jp, tr, se, nl
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Accès ouvert
2025
article
OpenAlex
Albin Björk, Mohamed Javad Wahadat, Maria Sánchez-Blázquez, Merijn Braams et autres
Objectives Activation of the type I interferon (IFN) pathway and autoreactive B cells are key immunopathogenic features of systemic lupus erythematosus (SLE), primary Sjögren’s disease (pSjD) and systemic sclerosis (SSc). TANK-binding kinase 1 (TBK1) is a mediator of type I IFN and …
nl, se
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Accès ouvert
2025
article
OpenAlex
Bart Humer, Willem A. Dik, Marjan A. Versnel
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex chronic disease of which the underlying (molecular) mechanisms are mostly unknown. An estimated 0.89% of the global population is affected by ME/CFS. Most patients experience a multitude of symptoms that severely affect their lives. …
nl
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Accès ouvert
2024
article
OpenAlex
Gijsbert J. Hötte, Maaike de Bie, Ronald O. B. de Keizer, Pieter Martijn Kolijn et autres
Background For the selective detection of thyroid-stimulating hormone receptor antibodies with stimulating properties (thyroid-stimulating immunoglobulins; TSI), a novel and rapid bioassay (Turbo TSI) has been introduced. We evaluate the clinical performance of Turbo TSI in Graves’ orbitopathy (GO) patients and compare it …
nl
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Accès ouvert
2024
article
OpenAlex
Sandy C. Bergkamp, Nick D. Bergkamp, Mohamed Javad Wahadat, Mariken P. Gruppen et autres
OBJECTIVES: In childhood-onset SLE (cSLE), patients have an increased risk of premature atherosclerosis. The pathophysiological mechanisms for this premature atherosclerosis are not yet completely understood, but besides traditional risk factors, the endothelium plays a major role. The first aim of this study …
nl
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Accès ouvert
2024
preprint
OpenAlex
Philip N. d'Ailly, Olivier J. M. Schäffers, C. Deugd, Marjan A. Versnel et autres
ABSTRACT Introduction Disease-Modifying Anti-Rheumatic Drug (DMARD) treatment fails to achieve clinical remission in a substantial proportion of patients with rheumatoid arthritis (RA). Patient-derived synovial tissue (ST)-signatures, thought to determine this heterogeneity of treatment responses, can be studied by single-cell RNA sequencing (scRNA-seq). …
nl
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Accès ouvert
2023
article
OpenAlex
Safae Hamkour, Eefje HM van der Heijden, Ana P. Lopes, Sofie L. M. Blokland et autres
OBJECTIVES: To assess to what extent leflunomide (LEF) and hydroxychloroquine (HCQ) therapy in patients with primary Sjögren's syndrome (RepurpSS-I) targets type I IFN-associated responses and to study the potential of several interferon associated RNA-based and protein-based biomarkers to predict and monitor treatment. …
nl
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Accès ouvert
2023
conference-abstract
OpenAlex
A. Björk, Mohamed Javad Wahadat, Merijn Braams, Cornelia G van Helden-Meeuwsen et autres
Background The immunopathology of systemic lupus erythematosus (SLE) is characterized by production of autoantibodies and aberrant activation of the type I interferon (IFN) system. In SLE, type I IFNs directly and indirectly affect differentiation and survival of autoreactive B cells, partly by …
nl, se, gr
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Accès ouvert
2023
article
OpenAlex
Mohamed Javad Wahadat, Sander J van Tilburg, Yvonne M. Mueller, Harm de Wit et autres
OBJECTIVE: To combine targeted transcriptomic and proteomic data in an unsupervised hierarchical clustering method to stratify patients with childhood-onset SLE (cSLE) into similar biological phenotypes, and study the immunological cellular landscape that characterises the clusters. METHODS: Targeted whole blood gene expression and …
nl
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