Accès ouvert
2025
article
OpenAlex
Bart Humer, Julia C. Berentschot, Cornelia G van Helden-Meeuwsen, L. Martine Bek et autres
PURPOSE: Long COVID (LC) is a long-term debilitating disease of which the exact pathophysiology is unknown. A dysregulated immune response resulting in hyperresponsive immune cells is hypothesized as a key mechanism in the development of LC. Several studies suggest that acute infections …
nl
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Accès ouvert
2025
article
OpenAlex
Albin Björk, Mohamed Javad Wahadat, Maria Sánchez-Blázquez, Merijn Braams et autres
Objectives Activation of the type I interferon (IFN) pathway and autoreactive B cells are key immunopathogenic features of systemic lupus erythematosus (SLE), primary Sjögren’s disease (pSjD) and systemic sclerosis (SSc). TANK-binding kinase 1 (TBK1) is a mediator of type I IFN and …
nl, se
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Accès ouvert
2023
article
OpenAlex
Safae Hamkour, Eefje HM van der Heijden, Ana P. Lopes, Sofie L. M. Blokland et autres
OBJECTIVES: To assess to what extent leflunomide (LEF) and hydroxychloroquine (HCQ) therapy in patients with primary Sjögren's syndrome (RepurpSS-I) targets type I IFN-associated responses and to study the potential of several interferon associated RNA-based and protein-based biomarkers to predict and monitor treatment. …
nl
(code pays fourni par la source)
Accès ouvert
2023
conference-abstract
OpenAlex
A. Björk, Mohamed Javad Wahadat, Merijn Braams, Cornelia G van Helden-Meeuwsen et autres
Background The immunopathology of systemic lupus erythematosus (SLE) is characterized by production of autoantibodies and aberrant activation of the type I interferon (IFN) system. In SLE, type I IFNs directly and indirectly affect differentiation and survival of autoreactive B cells, partly by …
nl, se, gr
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Mohamed Javad Wahadat, Sander J van Tilburg, Yvonne M. Mueller, Harm de Wit et autres
OBJECTIVE: To combine targeted transcriptomic and proteomic data in an unsupervised hierarchical clustering method to stratify patients with childhood-onset SLE (cSLE) into similar biological phenotypes, and study the immunological cellular landscape that characterises the clusters. METHODS: Targeted whole blood gene expression and …
nl
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Accès ouvert
2023
article
OpenAlex
Pieter Martijn Kolijn, Erika Huijser, Mohamed Javad Wahadat, Cornelia G van Helden-Meeuwsen et autres
Introduction: Activated B cells play a key role in the pathogenesis of primary Sjögren's syndrome (pSS) through the production of autoantibodies and the development of ectopic germinal centers in the salivary glands and other affected sites. Around 5-10% of pSS patients develop …
nl
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Accès ouvert
2022
article
OpenAlex
Mohamed Javad Wahadat, Hongchao Qi, Cornelia G van Helden-Meeuwsen, Erika Huijser et autres
OBJECTIVE: To study the association of serum IFNα2 levels measured by ultrasensitive single-molecule array (Simoa) and the IFN-I gene signature (IGS) with disease activity and determine whether these assays can mark disease activity states in a longitudinal cohort of childhood-onset SLE (cSLE) …
nl, de
(code pays fourni par la source)
Accès ouvert
2022
conference-paper
OpenAlex
Marleen Verkaaik, Wahadat M Javad, Hongchao Qi, Cornelia G van Helden-Meeuwsen et autres
Introduction Type-I interferon (IFN-I) pathway activation plays a pivotal role in the pathogenesis of SLE and has been proposed as biomarker for disease activity. IFN-I pathway activation can be measured by determining the expression of IFN-I stimulated genes or a so-called IFN …
nl, de
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Erika Huijser, Cornelia G van Helden-Meeuwsen, Dwin G.B. Grashof, Jessica R. Tarn et autres
Background Trained immunity – or innate immune memory – can be described as the long-term reprogramming of innate immune cells towards a hyperresponsive state which involves intracellular metabolic changes. Trained immunity has been linked to atherosclerosis. A subgroup of patients with primary …
nl, gb
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Accès ouvert
2022
article
OpenAlex
Kirby Tong‐Minh, Samantha van Hooijdonk, Marjan A. Versnel, Cornelia G van Helden-Meeuwsen et autres
INTRODUCTION: Myxovirus resistance protein 1 (MxA) is a biomarker that is elevated in patients with viral infections. The goal of this study was to evaluate the diagnostic value of MxA in diagnosing COVID-19 infections in the emergency department (ED) patients. METHODS: This …
nl
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Accès ouvert
2022
article
OpenAlex
Mohamed Javad Wahadat, Dieneke Schonenberg‐Meinema, Cornelia G van Helden-Meeuwsen, Sander J van Tilburg et autres
OBJECTIVES: Clinical phenotyping and predicting treatment responses in SLE patients is challenging. Extensive blood transcriptional profiling has identified various gene modules that are promising for stratification of SLE patients. We aimed to translate existing transcriptomic data into simpler gene signatures suitable for …
nl, cz
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Accès ouvert
2022
article
OpenAlex
Erika Huijser, Iris L. A. Bodewes, Mirthe S Lourens, Cornelia G van Helden-Meeuwsen et autres
OBJECTIVES: Cytosolic DNA-sensing pathway stimulation prompts type I IFN (IFN-I) production, but its role in systemic IFN-I pathway activation in primary SS (pSS) is poorly studied. Here we investigate the responsiveness of pSS monocytes and plasmacytoid dendritic cells (pDCs) to stimulator of …
nl
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