Learning from serum markers reflecting endothelial activation: longitudinal data in childhood-onset systemic lupus erythematosus
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Le résumé fourni par la source
OBJECTIVES: In childhood-onset SLE (cSLE), patients have an increased risk of premature atherosclerosis. The pathophysiological mechanisms for this premature atherosclerosis are not yet completely understood, but besides traditional risk factors, the endothelium plays a major role. The first aim of this study was to measure levels of SLE-associated markers involved in endothelial cell (EC) function and lipids in a cSLE cohort longitudinally in comparison with healthy controls (HC). Next aim was to correlate these levels with Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and nailfold capillaroscopic patterns. METHODS: Blood serum samples, videocapillaroscopy images and patient characteristics were collected in a multicentre longitudinal cSLE cohort and from age and sex comparable HC. Disease activity was evaluated by SLEDAI. A total of 15 EC markers and six lipids were measured in two longitudinal cSLE samples (minimum interval of 6 months) and in HC. Nailfold videocapillaroscopy images were scored according to the guidelines from the EULAR Study Group on Microcirculation in Rheumatic Diseases. RESULTS: In total, 47 patients with cSLE and 42 HCs were analysed. Median age at diagnosis was 15 years (IQR 12-16 years). Median time between t=1 and t=2 was 14.5 months (IQR 9-24 months). Median SLEDAI was 12 (IQR 6-18) at t=1 and 2 (IQR 1-4) at t=2. Serum levels of angiopoietin-2, CCL2, CXCL10, GAS6, pentraxin-3, thrombomodulin, VCAM-1 and vWF-A2 were elevated in cSLE compared with HC at t=1. While many elevated EC markers at t=1 normalised over time after treatment, several markers remained significantly increased compared with HC (angiopoietin-2, CCL2, CXCL10, GAS6, thrombomodulin and VCAM-1). CONCLUSION: In serum from patients with cSLE different markers of endothelial activation were dysregulated. While most markers normalised during treatment, others remained elevated in a subset of patients, even during low disease activity. These results suggest a role for the dysregulated endothelium in early and later phases of cSLE, possibly also during lower disease activity. TRIAL REGISTRATION NUMBER: NL60885.018.17.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Learning from serum markers reflecting endothelial activation: longitudinal data in childhood-onset systemic lupus erythematosus
- Date Crossref
- 01/09/2024
- Éditeur
- BMJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Emma Kinderziekenhuis pays non établi dans la noticeÉtablissement de santé
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University of Amsterdam pays non établi dans la noticeUniversité ou école supérieure
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Vrije Universiteit Amsterdam pays non établi dans la noticeUniversité ou école supérieure
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Erasmus University Rotterdam pays non établi dans la noticeUniversité ou école supérieure
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Zaans Medisch Centrum pays non établi dans la noticeÉtablissement de santé
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Amsterdam University Medical Centres (AUMC) Department of Paediatric Immunology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Science Amsterdam Institute for Molecular and Life Sciences (AIMMS) pays non établi dans la noticeUniversité ou école supérieure
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Department of Immunology pays non établi dans la noticeInstitution
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Erasmus University Medical Centre Department of Paediatric Rheumatology pays non établi dans la noticeUniversité ou école supérieure
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Department of Paediatrics pays non établi dans la noticeInstitution
Emma Kinderziekenhuis, University of Amsterdam et Vrije Universiteit Amsterdam, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.