Harm de Wit

Multiple sclerosis-associated HLA demarcates EBV-specific CD8+ T cells with an exhausted and brain residency phenotype.

Sanne Reijm, Ana M. Marques, Jasper Rip, Cato E. A. Corsten et autres

T cells less able to control EBV and more prone to infiltrate the CNS.

nl (code pays fourni par la source)

Multiple sclerosis-associated HLA demarcates EBV-specific CD8+ T cells with an exhausted and brain residency phenotype

Sanne Reijm, Ana M. Marques, Jasper Rip, Cato E. A. Corsten et autres

Abstract Specific HLA class I subtypes as well as circulating antibodies against Epstein-Barr virus (EBV) have been associated with increased susceptibility to develop multiple sclerosis (MS). It is currently unclear whether and how these risk factors are functionally related. Here, we assessed …

nl (code pays fourni par la source)

The Inflammation Spectrum of Monocytes in Relation to Obesity and Severity of Type 2 Diabetes (T2D), A Case-Control Study

Jorge Luis Tórtora Pérez, Lucy Baldeón, Fernando Sempértegui O, Behiye Özcan et autres

Introduction. Increased monocyte and macrophage inflammatory state and pro-inflammatory cytokine production are linked to type 2 diabetes (T2D). Research design and Methods. This is a case-control study aimed to examine the expression of 23 monocyte genes related to inflammation, adhesion, and repair …

ec, nl (code pays fourni par la source)

TLR9 plus STING Agonist Adjuvant Combination Induces Potent Neopeptide T Cell Immunity and Improves Immune Checkpoint Blockade Efficacy in a Tumor Model

Melisa D. Castro Eiro, Kou Hioki, Ling Vicky Li, Merel E. P. Wilmsen et autres

Immune checkpoint blockade (ICB) immunotherapies have emerged as promising strategies for the treatment of cancer; however, there remains a need to improve their efficacy. Determinants of ICB efficacy are the frequency of tumor mutations, the associated neoantigens, and the T cell response …

nl, kr, jp (code pays fourni par la source)

A combination of TLR9 and STING agonists induces potent neopeptide-specific T cell immunity and improves ICB efficacy in tumor models

Kou Hioki, Melisa D. Castro Eiro, Ling Li, Merel E. P. Wilmsen et autres

Abstract Immunotherapies such as immune checkpoint blockade (ICB) therapies have been developed in the last years as a promising strategy for the treatment of cancer, however there remains a need to improve their efficacy. The most critical factor that affects the efficacy …

nl, jp (code pays fourni par la source)

Targeted multiomics in childhood-onset SLE reveal distinct biological phenotypes associated with disease activity: results from an explorative study

Mohamed Javad Wahadat, Sander J van Tilburg, Yvonne M. Mueller, Harm de Wit et autres

OBJECTIVE: To combine targeted transcriptomic and proteomic data in an unsupervised hierarchical clustering method to stratify patients with childhood-onset SLE (cSLE) into similar biological phenotypes, and study the immunological cellular landscape that characterises the clusters. METHODS: Targeted whole blood gene expression and …

nl (code pays fourni par la source)

Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning

Yvonne M. Mueller, Thijs J. Schrama, Rik Ruijten, Marco W.J. Schreurs et autres

Quantitative or qualitative differences in immunity may drive clinical severity in COVID-19. Although longitudinal studies to record the course of immunological changes are ample, they do not necessarily predict clinical progression at the time of hospital admission. Here we show, by a …

nl, it, es, gr (code pays fourni par la source)

Monocyte mitochondrial dysfunction, inflammaging, and inflammatory pyroptosis in major depression

Maria S. Simon, Carmen Schiweck, Gara Arteaga-Henríquez, Sara Poletti et autres

BACKGROUND: The macrophage theory of depression states that macrophages play an important role in Major Depressive Disorder (MDD). METHODS: MDD patients (N = 140) and healthy controls (N = 120) participated in a cross-sectional study investigating the expression of apoptosis/growth and lipid/cholesterol …

de, be, it, nl, bg, fr (code pays fourni par la source)

Immunophenotyping and machine learning identify distinct immunotypes that predict COVID-19 clinical severity

Yvonne M. Mueller, Thijs J. Schrama, Rik Ruijten, Marco W.J. Schreurs et autres

Abstract Quantitative or qualitative differences in immunity may drive and predict clinical severity in COVID-19. We therefore measured modules of serum pro-inflammatory, anti-inflammatory and anti-viral cytokines in combination with the anti-SARS-CoV-2 antibody response in COVID-19 patients admitted to tertiary care. Using machine …

nl, es, gr (code pays fourni par la source)

Markers of neuroinflammation influence measures of cortical thickness in bipolar depression

Sara Poletti, Giovanni Leone, Thomas A. Hoogenboezem, Davide Ghiglino et autres

it (code pays fourni par la source)

Higher Baseline Proinflammatory Cytokines Mark Poor Antidepressant Response in Bipolar Disorder

Francesco Benedetti, Sara Poletti, Thomas A. Hoogenboezem, Clara Locatelli et autres

BACKGROUND: The clinical relevance of raised levels of circulating cytokines in bipolar disorder is still unclear. Cytokines influence neurotransmitters, neuroplasticity, and white matter integrity. An inconsistent literature suggests that higher cytokine levels could hamper antidepressant response. Total sleep deprivation (TSD) and light …

it (code pays fourni par la source)

Th17 cells correlate positively to the structural and functional integrity of the brain in bipolar depression and healthy controls

Sara Poletti, Harm de Wit, Elena Beatrice Mazza, Annemarie J. M. Wijkhuijs et autres

it (code pays fourni par la source)