Elizabeth Kicic‐Starcevich

Programming of the respiratory epithelium in utero - insights from the amniotic epithelial methylome

Patricia Agudelo‐Romero, Thomas Iosifidis, James I. Lim, Nina Kresoje et autres

Abstract Background Dysregulation of the airway epithelium contributes to recurrent wheezing and asthma and may have developmental origins. Direct interrogation of fetal airway epithelium is not feasible in humans limiting investigation of prenatal epithelial programming. Methods We performed high-throughput target-capture DNA methylation …

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Insights into the relationship between nasal bacterial composition and susceptibility to early-life respiratory disease: a pilot observational study

Jose Antonio Caparros-Martin, Elizabeth Kicic‐Starcevich, Patricia Agudelo‐Romero, David G. Hancock et autres

Abstract Background Early-life susceptibility to viral respiratory infections is associated with long-term respiratory morbidity in children. Currently, no reliable tools exist to predict susceptibility to these infections. Because the endogenous microbiota can influence pathogen virulence and airway inflammation, it represents a potential …

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Conservation of gene expression patterns between the amniotic and nasal epithelium at birth

David G. Hancock, Patricia Agudelo‐Romero, Elizabeth Kicic‐Starcevich, James I. Lim et autres

Background Amniotic epithelial cells are fetal-derived stem cells, capable of differentiating into all three germ layers, including mature epithelial cell populations. Here, we hypothesised that the amniotic epithelium might serve as a surrogate tissue source for investigating transcriptional profiles in the respiratory …

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Profiling epithelial viral receptor expression in amniotic membrane and nasal epithelial cells at birth

Bailee Renouf, Erika N. Sutanto, Courtney D. A. Kidd, James I. Lim et autres

INTRODUCTION: Children with wheeze and asthma present with airway epithelial vulnerabilities, such as impaired responses to viral infection. It is postulated that the in utero environment may contribute to the development of airway epithelial vulnerabilities. The aims of the study were to …

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Real time monitoring of respiratory viral infections in cohort studies using a smartphone app

David G. Hancock, Elizabeth Kicic‐Starcevich, Thijs Sondag, Rael Rivers et autres

Cohort studies investigating respiratory disease pathogenesis aim to pair mechanistic investigations with longitudinal virus detection but are limited by the burden of methods tracking illness over time. In this study, we explored the utility of a purpose-built AERIAL TempTracker smartphone app to …

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Conservation of gene expression patterns between the amniotic epithelium at birth and a newborn's nasal epithelium

David G. Hancock, Patricia Agudelo‐Romero, Elizabeth Kicic‐Starcevich, James I. Lim et autres

Background: Amniotic epithelial cells are foetal-derived stem cells, capable of differentiating into all three germ layers, including mature epithelial cell populations. However, the conservation between amniotic epithelium and other epithelial tissues has not been sufficiently explored. We hypothesised that the amniotic epithelium …

au (code pays fourni par la source)

Profiling epithelial viral receptor expression in amniotic membrane and nasal epithelial cells at birth

Bailee Renouf, Erika N. Sutanto, Courtney D. A. Kidd, James I. Lim et autres

Abstract Children with wheeze and asthma present with airway epithelial vulnerabilities, such as impaired responses to viral infection. It is postulated that the in utero environment may contribute to the development of airway epithelial vulnerabilities. The aims of the study were to …

au (code pays fourni par la source)

Airway epithelium respiratory illnesses and allergy (AERIAL) birth cohort: study protocol

Elizabeth Kicic‐Starcevich, David G. Hancock, Thomas Iosifidis, Patricia Agudelo‐Romero et autres

Introduction Recurrent wheezing disorders including asthma are complex and heterogeneous diseases that affect up to 30% of all children, contributing to a major burden on children, their families, and global healthcare systems. It is now recognized that a dysfunctional airway epithelium plays …

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REAL TIME MONITORING OF RESPIRATORY VIRAL INFECTIONS IN COHORT STUDIES USING A SMARTPHONE APP

David G. Hancock, Elizabeth Kicic‐Starcevich, Thijs Sondag, Rael Rivers et autres

ABSTRACT Background and Objectives Cohort studies investigating respiratory disease pathogenesis aim to pair mechanistic investigations with longitudinal virus detection but are limited by the burden of methods tracking illness over time. In this study, we explored the utility of a smartphone app …

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Nasal and Amnion Methylomes: Biomarkers for Smoke Exposure and Maternal Asthma

Patricia Agudelo‐Romero, Thomas Iosifidis, Elizabeth Kicic‐Starcevich, David G. Hancock et autres

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Altered dietary behaviour during pregnancy impacts systemic metabolic phenotypes

Charlotte E. Rowley, Samantha Lodge, Siobhon L. Egan, Catherine Itsiopoulos et autres

Rationale Evidence suggests consumption of a Mediterranean diet (MD) can positively impact both maternal and offspring health, potentially mediated by a beneficial effect on inflammatory pathways. We aimed to apply metabolic profiling of serum and urine samples to assess differences between women …

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Airway Epithelium Respiratory Illnesses and Allergy (AERIAL) birth cohort: study protocol

Elizabeth Kicic‐Starcevich, David G. Hancock, Thomas Iosifidis, Patricia Agudelo‐Romero et autres

ABSTRACT Introduction Recurrent wheezing disorders including asthma are complex and heterogeneous diseases that affect up to 30% of all children, contributing to a major burden on children, their families, and global healthcare systems. It is now recognized that a dysfunctional airway epithelium …

au, de, us (code pays fourni par la source)