Conservation of gene expression patterns between the amniotic and nasal epithelium at birth
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Le résumé fourni par la source
Background Amniotic epithelial cells are fetal-derived stem cells, capable of differentiating into all three germ layers, including mature epithelial cell populations. Here, we hypothesised that the amniotic epithelium might serve as a surrogate tissue source for investigating transcriptional profiles in the respiratory epithelium of newborns. Methods In this study, we compared gene expression profiles and weighted gene coexpression network structure in paired amniotic and newborn nasal epithelial samples from 85 participants in the Airway Epithelium Respiratory Illnesses and Allergy (AERIAL) cohort. Results In total, 11 867 genes (79.7%) were commonly expressed in both amniotic and nasal epithelium, with uniquely expressed genes (2563 and 458, respectively) enriched for biological functions related to the specialist function of each tissue ( e.g. developmental programs and ciliation, respectively). We observed a strong overlap in weighted gene coexpression network structure between both tissues, with 10 coexpression modules identified by consensus network analysis. Genes commonly expressed in both tissues and/or found in the consensus network modules were enriched for biologically relevant gene signatures and pathways related to airway function. We observed significant overlap in gene expression and network structure between the amniotic epithelium and published datasets of epithelial samples from lower airways and other epithelial tissues, including skin and oesophagus, suggesting a global epithelial signature. Conclusion We observed significant overlap in gene expression and network structure between paired amniotic and nasal epithelial samples, supporting the potential of amnion as a noninvasive and abundant tissue surrogate. Future studies investigating amnion-based biomarkers for respiratory exposures in utero and childhood disease outcomes are needed to extend these results towards clinical translation.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Conservation of gene expression patterns between the amniotic and nasal epithelium at birth
- Date Crossref
- 03/07/2025
- Éditeur
- European Respiratory Society (ERS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The Kids Research Institute Australia pays non établi dans la noticeOrganisation à but non lucratif
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The University of Western Australia Medical School pays non établi dans la noticeUniversité ou école supérieure
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Princess Margaret Hospital for Children pays non établi dans la noticeÉtablissement de santé
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Perth Children's Hospital Department of Respiratory and Sleep Medicine pays non établi dans la noticeÉtablissement de santé
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Australian Research Council pays non établi dans la noticeOrganisme public
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Friedrich Schiller University Jena European Virus Bioinformatics Centre pays non établi dans la noticeUniversité ou école supérieure
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Curtin University pays non établi dans la noticeUniversité ou école supérieure
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Wal-yan Respiratory Research Centre pays non établi dans la noticeStructure de recherche
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School of Molecular Sciences Australian Research Council Centre of Excellence in Plant Energy Biology pays non établi dans la noticeUniversité ou école supérieure
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School of Biomedical Sciences pays non établi dans la noticeUniversité ou école supérieure
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School of Population Health pays non établi dans la noticeUniversité ou école supérieure
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T. Iosifidis and S.M. Stick contributed equally as co-senior authors pays non établi dans la noticeInstitution
The Kids Research Institute Australia, Medical School — The University of Western Australia et Princess Margaret Hospital for Children, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.