Samantha Lodge

High resolution lipoprotein subfraction profiling identifies obesity associated distributional changes in LDL and HDL subfractions and particle ratios

Novia Minaee, Reika Masuda, Philipp Nitschke, Drew Hall et autres

BACKGROUND: Obesity is associated with adverse alterations in lipoprotein profiles and increased cardiometabolic risk, yet standard clinical lipid measures provide limited resolution of the underlying lipoprotein structure. Here, we perform a population-level characterisation of the impact of obesity on the high-resolution blood …

au, sa, gb, us, es, co, hk (code pays fourni par la source)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

Maren Jinks, Garth Maker, Emily C. Davies, BJ Boughton et autres

In vitro liver models combined with metabolomics approaches offer promising alternatives to animal testing in toxicology. In this study, we investigated concentration‐dependent effects of hydrogen peroxide (H 2 O 2 ) on the intra‐ and extracellular metabolome of HepG2 cells using 1 …

au (code pays fourni par la source)

Dose dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

Samantha Lodge

In vitro liver models combined with metabolomics approaches offer promising alternatives to animal testing in toxicology. In this study, we investigated concentration dependent effects of hydrogen peroxide (H2O2) on the intra and extracellular metabolome of HepG2 cells using 1H Nuclear Magnetic Resonance …

au (code pays fourni par la source)

Dose dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

Samantha Lodge

In vitro liver models combined with metabolomics approaches offer promising alternatives to animal testing in toxicology. In this study, we investigated concentration dependent effects of hydrogen peroxide (H2O2) on the intra and extracellular metabolome of HepG2 cells using 1H Nuclear Magnetic Resonance …

au (code pays fourni par la source)

Non-severe burn injury leads to sustained molecular changes in the brain in a murine model

Amira Allahham, Nutan Chaudhari, Sarah Walsh, Blair Z. Johnson et autres

Paediatric burn patients, including those with non-severe burns, have an increased risk of admission to hospital for mental health conditions for many years after the burn, even in children too young at the time of the burn to remember the incident. This …

au, cn (code pays fourni par la source)

Sex-based differences in long-term lipid metabolism, inflammation, and stress regulation after non-severe paediatric burns

Monique Ryan, Eva Kierath, Samantha Lodge, Reika Masuda et autres

Paediatric burn injuries are a global health concern with long-term health consequences, such as psychological, immune, and cardiovascular complications, that can persist even after non-severe injuries. Emerging evidence suggests that biological sex may influence post-burn outcomes in children, as female burn survivors …

au (code pays fourni par la source)

High adherence to a Mediterranean diet is associated with a diverse faecal microbiome and reduced systemic inflammation in a cohort of pregnant women

David Felipe García Mendez, Charlotte Rowley, Samantha Lodge, Siobhon Egan et autres

This repository contains the datasets required to reproduce the analyses presented in the manuscript: “High adherence to a Mediterranean diet is associated with a diverse faecal microbiome and reduced systemic inflammation in a cohort of pregnant women.” Study overview The study investigated …

au, us, gb (code pays fourni par la source)

High adherence to a Mediterranean diet is associated with a diverse faecal microbiome and reduced systemic inflammation in a cohort of pregnant women

David Felipe García Mendez, Charlotte Rowley, Samantha Lodge, Siobhon Egan et autres

This repository contains the datasets required to reproduce the analyses presented in the manuscript: “High adherence to a Mediterranean diet is associated with a diverse faecal microbiome and reduced systemic inflammation in a cohort of pregnant women.” Study overview The study investigated …

au, us, gb (code pays fourni par la source)

Preliminary Evidence of Blood DNA Methylation Changes in Pregnant Women Adhering to a Mediterranean Diet

Grace Tavelli, Nikki Schultz, Joanna Brisbane, Nina Kresoje et autres

Background/Objectives: Consumption of a Mediterranean diet (MD) has been associated with reduced incidence of non-communicable diseases and reduced overall mortality, with epigenomic effects representing plausible mediators. The aim of this pilot study was to explore potential epigenetic associations between DNA methylation markers …

au, us, gb (code pays fourni par la source)

MStargetR

Harrison Szemray, Luke Whiley, Vimalnath Nambiar, Nathan G. Lawler et autres

An R package to convert vendor files to ready to use concentration data.

Dynamic Lipidomic Responses to Inflammation and Physical Insult: A Comparative Review Across Blunt Force Trauma, Thermal Burn Injury, and Viral Infection

Harrison Szemray, Nathan Geoffrey Lawler, Samantha Lodge, Julien Wist et autres

Acute insults ranging from blunt force trauma and thermal injury to pathogenic infection elicit systemic inflammatory cascades intended to limit further tissue damage. These responses are accompanied by metabolic disturbances that generate distinct biochemical signatures measurable through advanced analytical platforms, such as …

au, gb, co (code pays fourni par la source)

Immune and metabolic signatures characterise constipation-driven endophenotypes in Parkinson’s disease

Abbey Figliomeni, Samantha J. Winter, Madison Abonnel, Jade E. Kenna et autres

Parkinson's disease (PD) is a progressive neurodegenerative disorder defined by motor impairments. However, people with PD (PwPD) experience a defined spectrum of non-motor symptoms, with gastrointestinal dysfunction the most common and earliest-presenting. Evidence suggests that PD pathology may originate in the gut, …

au, us, fr (code pays fourni par la source)