Airway Epithelium Respiratory Illnesses and Allergy (AERIAL) birth cohort: study protocol
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Le résumé fourni par la source
ABSTRACT Introduction Recurrent wheezing disorders including asthma are complex and heterogeneous diseases that affect up to 30% of all children, contributing to a major burden on children, their families, and global healthcare systems. It is now recognized that a dysfunctional airway epithelium plays a central role in the pathogenesis of recurrent wheeze, although the underlying mechanisms are still not fully understood. This prospective birth cohort aims to bridge this knowledge gap by investigating the influence of intrinsic epithelial dysfunction on the risk for developing respiratory disorders and the modulation of this risk by maternal morbidities, in utero exposures, and respiratory exposures in the first year of life. Methods and Analysis The Airway Epithelium Respiratory Illnesses and Allergy (AERIAL) study is nested within the ORIGINS Project and will monitor 400 infants from birth to five years. The primary outcome of the AERIAL study will be the identification of epithelial endotypes and exposure variables that influence the development of recurrent wheezing, asthma, and allergic sensitisation. Nasal respiratory epithelium at birth to six weeks, one, three, and five years will be analysed by bulk RNA-seq and DNA methylation sequencing. Maternal morbidities and in utero exposures will be identified on maternal history and their effects measured through transcriptomic and epigenetic analyses of the amnion and newborn epithelium. Exposures within the first year of life will be identified based on infant medical history as well as on background and symptomatic nasal sampling for viral PCR and microbiome analysis. Daily temperatures and symptoms recorded in a study-specific Smartphone App will be used to identify symptomatic respiratory illnesses. Ethics and Dissemination Ethical approval has been obtained from Ramsey Health Care HREC WA-SA (#1908). Results will be disseminated through open-access peer-reviewed manuscripts, conference presentations, and through different media channels to consumers, ORIGINS families, and the wider community.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Airway Epithelium Respiratory Illnesses and Allergy (AERIAL) birth cohort: study protocol
- Date Crossref
- 03/05/2023
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The Kids Research Institute Australia pays non établi dans la noticeOrganisation à but non lucratif
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Princess Margaret Hospital for Children pays non établi dans la noticeÉtablissement de santé
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Perth Children's Hospital Department of Respiratory and Sleep Medicine pays non établi dans la noticeÉtablissement de santé
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The University of Western Australia pays non établi dans la noticeUniversité ou école supérieure
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Curtin University pays non établi dans la noticeUniversité ou école supérieure
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Jena Bioscience (Germany) pays non établi dans la noticeEntreprise
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Edith Cowan University pays non établi dans la noticeUniversité ou école supérieure
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University of Arizona Asthma and Airway Disease Research Center pays non établi dans la noticeUniversité ou école supérieure
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Telethon Kids Institute pays non établi dans la noticeStructure de recherche
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School of Medicine Centre for Cell Therapy and Regenerative Medicine pays non établi dans la noticeUniversité ou école supérieure
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School of Population Health pays non établi dans la noticeUniversité ou école supérieure
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European Virus Bioinformatics Centre pays non établi dans la noticeInstitution
The Kids Research Institute Australia, Princess Margaret Hospital for Children et Department of Respiratory and Sleep Medicine — Perth Children's Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.