Siu Yuen Chan

HPV Vaccine Communication and Administration for the Prevention of Oropharyngeal Cancer in Dental Primary Care: Perspectives of Professionals and Students—A Systematic Review

Sik-Kwan Chan, TW Mak, Ollie Yiru Yu, Victor Lee et autres

Background/Objectives: The rising prevalence of HPV-associated oropharyngeal cancer (OPC) presents a significant concern, prompting dental professionals to play an increasingly vital role in HPV vaccination and prevention within primary healthcare. This study aimed to assess the current knowledge, attitudes, and practices of …

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TSPYL1 as a Critical Regulator of TGFβ Signaling through Repression of TGFBR1 and TSPYL2

Huiqi Tan, Mia Xinfang Miao, Rylee Xu Luo, Joan So et autres

Nucleosome assembly proteins (NAPs) have been identified as histone chaperons. Testis-Specific Protein, Y-Encoded-Like (TSPYL) is a newly arisen NAP family in mammals. TSPYL2 can be transcriptionally induced by DNA damage and TGFβ causing proliferation arrest. TSPYL1, another TSPYL family member, has been …

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Sex specific regulation of TSPY-Like 2 in the DNA damage response of cancer cells

Miriana Cardano, Martina Magni, Roberta R. Alfieri, Siu Yuen Chan et autres

Females have a lower probability to develop somatic cancers and a better response to chemotherapy than males. However, the reasons for these differences are still not well understood. The X-linked gene TSPY-Like 2 (TSPYL2) encodes for a putative tumor suppressor protein involved …

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Targeting androgen receptor in BQ323636.1 overexpressing oestrogen receptor-positive breast cancer to overcome aromatase inhibitor resistance: abridged secondary publication.

H Tsoi, E P S Man, J Lok, Chin-Long Cheng et autres

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Targeted Gene Sanger Sequencing Should Remain the First-Tier Genetic Test for Children Suspected to Have the Five Common X-Linked Inborn Errors of Immunity

Koon-Wing Chan, Chung-Yin Wong, Daniel Leung, Xingtian Yang et autres

To address inborn errors of immunity (IEI) which were underdiagnosed in resource-limited regions, our centre developed and offered free genetic testing for the most common IEI by Sanger sequencing (SS) since 2001. With the establishment of The Asian Primary Immunodeficiency (APID) Network …

hk, cn, in, Tunisie, sg, vn, id, ph, Algérie, my, tw, Afrique du Sud, th, lk, Maroc, bh (code pays fourni par la source)

The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer

Tze Zhen Evangeline Kang, Lina Zhu, Yang Du, Dongbo Ding et autres

The recent discovery of the cancer-associated E76K mutation in histone H2B (H2BE76-to-K) in several types of cancers revealed a new class of oncohistone. H2BE76K weakens the stability of histone octamers, alters gene expression, and promotes colony formation. However, the mechanism linking the …

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943P The most optimal induction chemotherapy regimen for loco-regionally advanced nasopharyngeal carcinoma: A network meta-analysis

Sherry Kit Wa Chan, Cheuk‐Wai Choi, Ka On Lam, Siu Yuen Chan et autres

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1379P Real-world (RW) clinical outcomes of patients with metastatic non-small cell lung cancer (mNSCLC) in the United Kingdom

J. Lester, Carles Escriu, Sabbir Khan, Emmanuel W. Hudson et autres

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TSPYL1 regulates steroidogenic gene expression and male factor fertility in mice

Lei Peng, Eva Hin Wa Leung, Joan So, Priscilla Hoi Shan Mak et autres

OBJECTIVE: To determine the importance of testis-specific, Y-encoded-like 1 (TSPYL1) in survival and male factor fertility in mice. DESIGN: Experimental prospective study. SETTING: Research laboratories in a university medical faculty. ANIMALS: We generated Tspyl1 knockout (KO) mouse lines by CRISPR/Cas9. The lines …

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Lrrc7 mutant mice model developmental emotional dysregulation that can be alleviated by mGluR5 allosteric modulation

Chi Ho Chong, Qi Li, Priscilla Hoi Shan Mak, Cypress Chun Pong Ng et autres

LRRC7 has been identified as a candidate gene for severe childhood emotional dysregulation. Direct experimental evidence for a role of LRRC7 in the disease is needed, as is a better understanding of its impact on neuronal structure and signaling, and hence potential …

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Structural instability of lamin A tail domain modulates its assembly and higher order function in Emery–Dreifuss muscular dystrophy

Muneyo Mio, Toshihiko Sugiki, Chie Matsuda, Hiroaki Mitsuhashi et autres

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Real‐world treatment patterns and outcomes in refractory metastatic colorectal cancer

Chi‐Leung Chiang, Cheuk‐Wai Choi, K.O. Lam, Bob Chan et autres

AIM: To investigate treatment patterns and outcomes of metastatic colorectal cancer (mCRC) patients beyond second progression (PD2) since regorafenib and TAS-102 became available in Hong Kong. METHODS: The clinical records of consecutive mCRC patients who were treated beyond PD2 at Department of …

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