Sik-Kwan Chan

Late mortality and chronic health condition among 7893 five-year survivors of nasopharyngeal cancer in Hong Kong, China: a population-based cohort study

Chi‐Leung Chiang, Philip Chun-Ming Au, Sik-Kwan Chan, Ching‐Lung Cheung et autres

Clinical and Proteomic Biomarkers of Trifluridine/Tipiracil in Fluoropyrimidine-Refractory Advanced Pancreatic Adenocarcinoma: A Single-Arm Phase II Trial

Chi‐Leung Chiang, Sik-Kwan Chan, Ann Shing Francis Lee, Ka Ming Eric Lam et autres

PURPOSE: Patients with refractory pancreatic cancer have limited therapeutic option and dismal prognoses. This study aimed to evaluate the efficacy and safety of trifluridine/tipiracil (FTD/TPI) in patients with fluoropyrimidine-refractory pancreatic cancer and their predictive biomarkers. METHODS: In this single-arm phase II clinical …

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Cross-Platform Gene Signature to Predict Survival Outcomes for Nasopharyngeal Carcinoma

Hui Li, Qiuyu Jing, James Chung Hang Chow, Wah Cheuk et autres

PURPOSE Nasopharyngeal carcinoma (NPC) is a multifactorial malignancy often diagnosed at an advanced stage due to nonspecific early symptoms. Accurate prognostic stratification is essential for individualized therapy but remains challenging because of biological and clinical heterogeneity. This study aimed to develop and …

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In Reply to Cao and Wang

Chi Leung Chiang, Sik-Kwan Chan, Ryo Wan Lung Yeung, Keith Wan Hang Chiu

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HPV vaccine discussion and administration in dental primary healthcare settings for oropharyngeal cancer prevention: A systematic review from dental patients’ perspectives

TW Mak, Sik-Kwan Chan, Ollie Yiru Yu, Victor Lee et autres

BACKGROUND/OBJECTIVE: The dental office is a critical frontline for preventing human papillomavirus (HPV)-related oropharyngeal cancer (OPC), as dentists are trusted primary oral health providers who can advise on this major cancer risk. This systematic review assessed dental patients' perceptions of HPV vaccine …

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Compensatory Hypertrophy and Changes of Liver Function After Sequential Transarterial Chemoembolization, Stereotactic Body Radiation Therapy, and Immunotherapy (START-FIT) in Unresectable Hepatocellular Carcinoma

Ryo Wan Lung Yeung, Keith Wan Hang Chiu, Sik-Kwan Chan, Natalie Sean Man Wong et autres

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Pre‐existing CD95‐based Temra immunity in patients with recurrent/metastatic nasopharyngeal carcinoma predicts response and hyperprogression to dual PD‐L1 and TGFβ inhibition

Ngar‐Woon Kam, Jeffrey Yan Ho Lau, Cho Yiu Lau, Tai‐Chung Lam et autres

Abstract None.

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Long-Term Outcome of Stereotactically Designed Hypofractionated Image Guided Radiation Therapy in Large, Unresectable Hepatocellular Carcinoma

Natalie Sean Man Wong, Francis Ann Shing Lee, Venus Wan Yan Lee, Sik-Kwan Chan et autres

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Efficacy of systemic therapy for advanced hepatocellular carcinoma based on etiology: A systematic review and network meta-analysis of randomized phase III trials

Charlene Hoi Lam Wong, Sik-Kwan Chan, Regina Cheuk‐Lam Lo, Chi‐Leung Chiang

BACKGROUND: Robust comparative data on the treatment efficacy of hepatocellular carcinoma (HCC) based on disease etiology are lacking. We conducted a network meta-analysis (NMA) and pairwise meta-analysis to evaluate the survival of patients with advanced HCC treated with systemic therapies based on …

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Effect of statins on the mortality of long-term survivors of nasopharyngeal carcinoma.

Ruyu Xu, Chi‐Leung Chiang, Philip Chun-Ming Au, Sik-Kwan Chan et autres

e18084 Background: Despite the significant increase in five-year overall survival (OS) rate of patients with nasopharyngeal cancer (NPC) over the past few decades, long-term survivors remain at risk of excessive mortality and morbidity. Several population-based studies have suggested an association between statin …

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HPV Vaccine Communication and Administration for the Prevention of Oropharyngeal Cancer in Dental Primary Care: Perspectives of Professionals and Students—A Systematic Review

Sik-Kwan Chan, TW Mak, Ollie Yiru Yu, Victor Lee et autres

Background/Objectives: The rising prevalence of HPV-associated oropharyngeal cancer (OPC) presents a significant concern, prompting dental professionals to play an increasingly vital role in HPV vaccination and prevention within primary healthcare. This study aimed to assess the current knowledge, attitudes, and practices of …

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Abstract No. 132 Comparing Demographic Factors and Outcomes in Hepatocellular Carcinoma Treatment: Evaluation of Y90 Radioembolization versus Combined TACE plus MWA

Isaura S. Ibrahim, Sik-Kwan Chan, Bridget F. Kilbride, P. Vakil et autres

Results: Among 80 patients who were scheduled to receive sameday radioembolization, 4 were excluded because of a high estimated lung dose, leading to the rejection of the radioembolization procedure.The remaining 76 patients, who had a mean tumor size of 9.4 cm, were …

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