Hery Urra

Abstract 3435 IRE1/XBP1/BDNF axis role in the interaction between neurons and glioblastoma cells during brain cancer progression

Juan Francisco Silva Agüero, Ignacio Tapia-Dufey, Tapia-Dufey, Giovanni Tamburini et autres

Glioblastoma (GB) is an aggressive brain tumor that establishes functional synaptic connections with neurons, enhancing tumor progression. The mechanisms governing this neuron–tumor interaction remain poorly understood. Emerging evidence indicates that activation of the neuronal IRE1/XBP1 signaling pathway, a key branch of the …

Characterization of the mutational status of glioblastoma and high-grade astrocytomas in a Latin American cohort

Rodrigo Fernández-Gajardo, Hery Urra, Mauricio Sáez, Philippe Pihán et autres

High-grade astrocytomas vary in incidence and mortality across populations, with Hispanic and Latino groups largely underrepresented in genomic epidemiology studies. This study characterizes the presence of known mutations of high-grade astrocytomas in a Latin American cohort through targeted genomic analysis of 70 …

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In Vivo Glioblastoma Tumor Modeling via Stereotaxic Injection in Mice for Tumor Progression Studies

Juan Francisco Silva-Agüero, Ignacio Tapia-Dufey, Luis González-Rojas, Hery Urra et autres

Glioblastoma (GB) is a highly aggressive brain cancer with a median survival of under 2 years despite conventional therapy. Research efforts frequently use murine in vivo models to study cancer progression and tumor growth, as these models recapitulate critical aspects of the …

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Evaluating the link between periodontitis and oral squamous cell carcinoma through Wnt/β-catenin pathway: a critical review

Montserrat Reyes, Hery Urra, Daniel Peña‐Oyarzún

Oral Squamous Cell Carcinoma (OSCC), the main form of oral cancer, is a major health problem globally that affects 400,000 people every year. It has been postulated that periodontitis, a chronic inflammatory disease characterized by alveolar bone resorption, is an independent risk …

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Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1

Younis Hazari, Lama Habbouche, Valeria A. Garcia Lopez, Hery Urra et autres

BACKGROUND AIMS: Collagen is the main cargo of the secretory pathway, contributing to hepatic fibrogenesis due to extensive accumulation of extracellular matrix. An excess of collagen deposition is a characteristic feature of several chronic liver diseases. Collagen overproduction imposes pressure on the …

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The UPRising connection between endoplasmic reticulum stress and the tumor microenvironment

Hery Urra, Raúl Aravena, Lucas González-Johnson, Claudio Hetz

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Author Reply to Peer Reviews of Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1

Younis Hazari, Hery Urra, Valeria A. Garcia Lopez, Lama Habbouche et autres

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IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts

Chao Li, Shiqian Li, Guangyu Zhang, Qinfeng Li et autres

BACKGROUND: Cardiomyocyte growth is coupled with active protein synthesis, which is one of the basic biological processes in living cells. However, it is unclear whether the unfolded protein response transducers and effectors directly take part in the control of protein synthesis. The …

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Characterization of the mutational landscape of high-grade gliomas in a Latin American cohort

Rodrigo Fernández-Gajardo, Hery Urra, Mauricio Sáez, Philippe Pihán et autres

Abstract Background Glioblastoma, an aggressive form of high-grade glioma, exhibits variations in the incidence and mortality patterns between populations of different ancestry. However, Hispanic and Latino populations remain largely underrepresented in studies of molecular characterization. Here we characterized the mutagenic landscape of …

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LOX rises as a potential survival biomarker: A commentary on “Identification of LOX as a candidate prognostic biomarker in Glioblastoma multiforme” by Liu et al.

Eduardo Silva-Pavez, Hery Urra

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The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis

Younis Hazari, Hery Urra, Valeria A. Garcia Lopez, Javier Diaz et autres

Abstract Collagen is one the most abundant proteins and the main cargo of the secretory pathway, contributing to hepatic fibrosis and cirrhosis due to excessive deposition of extracellular matrix. Here we investigated the possible contribution of the unfolded protein response, the main …

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Emerging roles of endoplasmic reticulum proteostasis in brain development

Giselle Espinosa Vásquez, Danilo B. Medinas, Hery Urra, Claudio Hetz

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