Luis González-Rojas

Abstract 3435 IRE1/XBP1/BDNF axis role in the interaction between neurons and glioblastoma cells during brain cancer progression

Juan Francisco Silva Agüero, Ignacio Tapia-Dufey, Tapia-Dufey, Giovanni Tamburini et autres

Glioblastoma (GB) is an aggressive brain tumor that establishes functional synaptic connections with neurons, enhancing tumor progression. The mechanisms governing this neuron–tumor interaction remain poorly understood. Emerging evidence indicates that activation of the neuronal IRE1/XBP1 signaling pathway, a key branch of the …

In Vivo Glioblastoma Tumor Modeling via Stereotaxic Injection in Mice for Tumor Progression Studies

Juan Francisco Silva-Agüero, Ignacio Tapia-Dufey, Luis González-Rojas, Hery Urra et autres

Glioblastoma (GB) is a highly aggressive brain cancer with a median survival of under 2 years despite conventional therapy. Research efforts frequently use murine in vivo models to study cancer progression and tumor growth, as these models recapitulate critical aspects of the …

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Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1

Younis Hazari, Lama Habbouche, Valeria A. Garcia Lopez, Hery Urra et autres

BACKGROUND AIMS: Collagen is the main cargo of the secretory pathway, contributing to hepatic fibrogenesis due to extensive accumulation of extracellular matrix. An excess of collagen deposition is a characteristic feature of several chronic liver diseases. Collagen overproduction imposes pressure on the …

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Modulation of gut microbiota through physical activity in individuals with obesity—a systematic review

Luis González-Rojas, Fabien Magne, Martín Gotteland

Overweight/obesity (OW/OB) has been associated with gut dysbiosis, changes in gastrointestinal motility and sedentary behavior, contributing to metabolic and inflammatory alterations. This systematic review aims to assess the evidence supporting the influence of physical activity and exercise on gut microbiota composition and …

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Effect of a Concurrent Training Program with and Without Metformin Treatment on Metabolic Markers and Cardiorespiratory Fitness in Individuals with Insulin Resistance: A Retrospective Analysis

Jairo Azócar-Gallardo, Alex Ojeda-Aravena, Eduardo Báez-San Martín, Tomás Herrera-Valenzuela et autres

Background: Type 2 diabetes mellitus is a metabolic disorder characterized by insulin resistance (IR), which is prevalent worldwide and has significant adverse health effects. Metformin is commonly prescribed as a pharmacological treatment. Physical exercise is also recognized as an effective regulator of …

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Influence of Body Composition on Cardiorespiratory Fitness and Metabolic Markers in Physically Inactive Individuals with Insulin Resistance: An Observational Study

Jairo Azócar-Gallardo, Alex Ojeda-Aravena, Eduardo Báez-San Martín, Víctor Campos-Uribe et autres

The aim of this study was to determine body composition influence on cardiorespiratory fitness and metabolic markers in physically inactive individuals with insulin resistance (IR). Nineteen overweight and obese (body mass index [BMI] 25.0–29.9 kg·m−2; ≥ 30.0 kg·m−2, respectively) patients diagnosed with …

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Overweight and Obese Adult Patients Show Larger Benefits from Concurrent Training Compared with Pharmacological Metformin Treatment on Insulin Resistance and Fat Oxidation

Jairo Azócar-Gallardo, Rodrigo Ramírez‐Campillo, José Afonso, Mário Sá et autres

Metformin, a drug widely used to treat insulin resistance, and training that combines aerobic and strength exercise modalities (i.e., concurrent training) may improve insulin sensitivity. However, there is a paucity of clinical trials investigating the effects of concurrent training, particularly on insulin …

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Recomendaciones de actividad física y ejercicio en el paciente adulto sometido a cirugía bariátrica. Documento de Consenso

JAVIERA CANCINO-RAMÍREZ, Erika J. Troncoso-Ortiz, Johanna Pino, Mariela Olivares et autres

Physical exercise is useful in people who underwent bariatric surgery. However, the right dosage is still a topic for discussion. The aim of this article is to consolidate the prescription criteria for physical activity and exercise in bariatric patients. A panel of …

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Oxygen pulse as a protective factor of insulin resistance in sedentary women with overweight or obesity

Luis González-Rojas, Johana Patricia Soto-Sánchez, Marcelo Cano Capellacci, Javiera Cancino Ramírez

BACKGROUND: obesity is associated with insulin resistance (IR). Through exercise, insulin resistant obese patients can effectively improve theircardiorespiratory fitness (CRF). The effect of exercise on patients CRF can be determined by oxygen pulse (PO2) analysis. Despite its usefulness, there is limited literature …

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Cardiorespiratory fitness and fat oxidation during exercise as protective factors for insulin resistance in sedentary women with overweight or obesity

Javiera Cancino Ramírez, Johana Patricia Soto-Sánchez, Hermann Zbinden Foncea, Manuel Moreno González et autres

INTRODUCTION: obesity is a global pandemic and it is the biggest risk factor for death worldwide nowadays. Studies suggest that both cardiorespiratory fitness and fat oxidation in exercise are related to insulin resistance and type 2 diabetes mellitus, and they could be …

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Programa de trasplante hepático en el Hospital de Pediatría Juan P. Garrahan: 16 años de experiencia

Guillermo Cervio, Marcelo Dip, Gustavo Bianco, Luis González-Rojas et autres