Abstract 3435 IRE1/XBP1/BDNF axis role in the interaction between neurons and glioblastoma cells during brain cancer progression
Juan Francisco Silva Agüero, Ignacio Tapia-Dufey, Tapia-Dufey, Giovanni Tamburini et autres
Glioblastoma (GB) is an aggressive brain tumor that establishes functional synaptic connections with neurons, enhancing tumor progression. The mechanisms governing this neuron–tumor interaction remain poorly understood. Emerging evidence indicates that activation of the neuronal IRE1/XBP1 signaling pathway, a key branch of the …
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Journal of Biological Chemistry