Philippe Pihán

The longevity gene APOE2 enhances pericyte function and reduces lipid droplets

Rais Reskiawan A Kadir, Joanna Bons, Genesis Vega Hormazabal, Prasanna Vadhana Ashok Kumaar et autres

Pericytes are critical for maintaining blood-brain barrier (BBB) integrity and have emerged as key contributors to Alzheimer's disease (AD) pathogenesis. Although the apolipoprotein E2 (APOE2) allele is associated with reduced AD risk and increased longevity, its impact on pericyte function is unclear. …

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Characterization of the mutational status of glioblastoma and high-grade astrocytomas in a Latin American cohort

Rodrigo Fernández-Gajardo, Hery Urra, Mauricio Sáez, Philippe Pihán et autres

High-grade astrocytomas vary in incidence and mortality across populations, with Hispanic and Latino groups largely underrepresented in genomic epidemiology studies. This study characterizes the presence of known mutations of high-grade astrocytomas in a Latin American cohort through targeted genomic analysis of 70 …

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Proteostasis decline and endoplasmic reticulum stress in aging: Implications for cellular senescence and senescence-associated secretory phenotype regulation

Philippe Pihán, Lisa Ellerby, Claudio Hetz

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ER–mitochondria contact sites: a refuge for mitochondrial mRNAs under ER stress

Philippe Pihán, Lisa Ellerby, Claudio Hetz

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Author Reply to Peer Reviews of Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1

Younis Hazari, Hery Urra, Valeria A. Garcia Lopez, Lama Habbouche et autres

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Characterization of the mutational landscape of high-grade gliomas in a Latin American cohort

Rodrigo Fernández-Gajardo, Hery Urra, Mauricio Sáez, Philippe Pihán et autres

Abstract Background Glioblastoma, an aggressive form of high-grade glioma, exhibits variations in the incidence and mortality patterns between populations of different ancestry. However, Hispanic and Latino populations remain largely underrepresented in studies of molecular characterization. Here we characterized the mutagenic landscape of …

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Calcium signaling in lysosome-dependent cell death

Mateus Milani, Philippe Pihán, Claudio Hetz

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The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis

Younis Hazari, Hery Urra, Valeria A. Garcia Lopez, Javier Diaz et autres

Abstract Collagen is one the most abundant proteins and the main cargo of the secretory pathway, contributing to hepatic fibrosis and cirrhosis due to excessive deposition of extracellular matrix. Here we investigated the possible contribution of the unfolded protein response, the main …

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Mitochondria-associated niches in health and disease

Mateus Milani, Philippe Pihán

The appreciation of the importance of interorganelle contacts has steadily increased over the past decades. Advances in imaging, molecular biology and bioinformatic techniques allowed the discovery of new mechanisms involved in the interaction and communication between organelles, providing novel insights into the …

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Proapoptotic RECS1: a requisite gateway to lysosomal dysfunction and death

Claudio Hetz, Philippe Pihán, Mateus Milani

For a long time since their discovery by Christian de Duve in the 1950s, lysosomes have been referred to almost exclusively as passive garbage bags; the endpoint in the degradation of intra- and extracellular cargo. The catabolic function of lysosomes is accomplished …

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Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1

Philippe Pihán, Fernanda Lisbona, Janina Borgonovo, Sandra Edwards‐Jorquera et autres

and zebrafish models. Our results unveil an unanticipated function for RECS1 as a proapoptotic component of the TMBIM family that ignites cell death programs at lysosomes.

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A phenolic-rich extract from Ugni molinae berries reduces abnormal protein aggregation in a cellular model of Huntington’s disease

Rodrigo Pérez-Arancibia, José Luis Ordóñez, Alexis Rivas, Philippe Pihán et autres

Accumulation of misfolded proteins in the brain is a common hallmark of most age-related neurodegenerative diseases. Previous studies from our group identified the presence of anti-inflammatory and antioxidant compounds in leaves derived from the Chilean berry Ugni molinae (murtilla), in addition to …

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