Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial
Chris Parker, Noel W. Clarke, Adrian Cook, Howard Kynaston, Charles Catton, William Cross, Raj Persad, Fred Saad, Lorna C Bower, John Logue, Heather Payne, Silvia Forcat, Cindy Goldstein, Claire Murphy, J R Anderson, Maroie Barkati, David Bottomley, Jennifer Mary Rose Branagan, Ananya Choudhury, Peter Chung, Lyn Cogley, Chee Goh, Peter Hoskin, Vincent Khoo, Shawn Malone, Lindsey Masters, Stephen Morris, Abdenour Nabid, A. Ong, Rakesh Raman, Kathryn Tarver, Alison Tree, Jane Worlding, James Wylie, Anjali Zarkar, Wendy R. Parulekar, Mahesh Parmar, Matthew R. Sydes, Claire Amos, Katherine E. Beaney, Katharine Bellenger, Chris Brawley, Christina Chung, Andrew Embleton-Thirsk, Jenna Grabey, Dominic Hague, Anna Herasimtschuk, Zaheer Islam, Gordana Jovic, C. Maniatis, Fatima Mohamed, Rachel C. Morgan, Dipa Noor, Max Parmar, Paul R. Patterson, Holly Pickering, Cheryl Pugh, Mary Rauchenberger, Helena Ribeiro, Carol Roach, Fatimah Seray-Wurie, Preetha Shaji, Hannah Sims, Ben Spittle, Nancy Tappenden, Lilian Tsang, Barbara Uscinska, Teddy Brown, Sue Casey, Cathy N. Davidson, Conor Dellar, Mandy Fletcher, Ralph M. Meyer, Karen Murphy, Harriet Richardson, K. Martin Richardson, Kate Whelan, Donald Bissett, Shelagh Bonner-Shand, Judith Grant, Rory Lynch, Graham Macdonald, Marie McWilliam, Rachel Moir, Sue Rodwell, Kirsty Shearer, Margaret Smith, Louise Binns, Maxine Briggs, Simon Brown, Nathalie Casanova, Katy M. Clark, Jasmine Hartley, Ann Henry, Helen Henson, Ganesan Jeyasanger, Judy McAlister, Sharron Parkinson, Alison Shaw, C. J. Alcock, Joanne E. Brady, Philip Camilleri, Janice Carpenter, Emma Hogbin, Katherine Hyde, Roisin Kavanagh, Alice Ngumo, Cheryl Padilla-Harris, N. Panakis, Thinn Pwint, Ami Sabharwal, Tracey Stammers, Helena Stone, Gail Varley, Andrew Weaver, Hazel Wynn, Elaine Allan, Jawaher Ansari, Philip Cannon, Ross Carruthers, Claudia Coubrough, Chloe Cowan, Hilary Glen, Janet Graham, Maryon Hardie, Clare J. Love, Nicholas MacLeod, Rana Mahmood, Jane McClements, Brian McGlynn, Margaret McKernan, N. Niall McLeod, Aqilah Othman, Kristy Ross, Patricia Roxburgh, Maureen Templeton, Claudia Turley, Mark Wilson, Zulfiqer Ali, Kelly S. Andrews, Rebecca Burns, Caryl Butterworth, Thomas Coventry, Angela D. Evans, Gareth Jones, Sion Lewis, Nikhil Babu Oommen, S. E. Owen, Wendy Saxton, Sister Hayley Tapping, Dianne Thomas, Rachel Thomas, Beth Ann Walker, Rachel Williams, Susan Collard, Victoria Ford, Frances Goodhind, Becky Holbrook, Elizabeth Kershaw, Samantha Ley, Maria Cristina Martinez, Anne McCormack, Denise Sheehan, Elizabeth Toy, Lynne Van-Koutrik, Mohini Varughese, Katherine Aitken, David J. Barlow, Louise Beattie, Godfrey Bownie-Mukumbu, Rachel Bryan, Victoria Corner, Abigail Edwards, Adrienn Fazekasne Fulep, Teresa Guerrero Urbano, Julie Gwilt, Liz Happle, Dee Jackman, Beata Krysta, Sangeeta Paisey, Richard Shaffer, Jackie Smith, Rosalyne Westley, Hilawati Yusof, Rowan Appleby, Joanne Avis, Mark Beresford, Ruth Brydon-Hill, Christine Cox, Samantha Curtis, Christine Elwell, Olivera Frim, Beatrice Hamilton, Zoe Hudson, A. Jenner, Mark Mantle, Jessica Mason, Susan Masson, Jonathan McFarlane, H Newman, Abigail Pocock, Bryony Robertson, E. Tomlinson, Rebecca Wassall, Sister Tania Williams, Grace Brown, Peter Clarke, Aiden Cole, Jane Cousins, Gail Gilchrist, Emma Hanna, J. Harney, Stacey Hetherington, Fionnuala Houghton, S. Hynds, Suneil Jain, R. Johnston, Patrick F. Keane, C. Lyons, J. McAleese, Jo McAllister, Karen McKenna, D. Mitchell, Stacey Murray, Joe M. O’Sullivan, Nambi Rajan, Poh Lin Shum, D.P. Stewart, S. Stranex, Grace Totten, Madhura Chandrashekara, Ellen Drew, Mary Drew, Julie Fletcher, Tina Gamble, Rachel Lokes, Ann Schumacher, Kavitha Shetty, Sundip Sohanpal, James Whitehouse, Daniel Ford, J. Glaholm, Daniel Lenton, Rachael O'Beney, H.F. Taylor, Helen Thomas, Samantha Chetiyawardana, Alissa N. Doherty, Ahmed El-Modir, Melanie Gunn, Nicholas D. James, L Kedge, Aliyah Mannan, Josephine Marange, Andrew P. Morrison, Maryanne Okubanjo, Darlletta Olaniyi-Oduntan, Zhane Peterkin, George Preece, Zayn Qureshi, Liliam Ross, Tarandip Samra, Elizabeth Southgate, Rebekah Stephens, Robert Stevenson, Phillip Watson-Jones, Danya Abdulwahid, Sarah Ainsworth, Sue Ashworth, Karen Stansberry Beard, Natalie Charnley, Parth Desai, Bethany Fielding, Jan Flaherty, Diane Forrest, Helen Frankland, Jeanette Hargreaves, Joanne Henry, A. Hugill, Karen Jewers, Sarah Keith, Stephen Kilroy, Jennifer King, Omi Parikh, Karen Riley, Janet Ryan-Smith, Jacqueline Thomas, Catherine Thompson, Vivienne Tickle, Lynsey Waring, Marcus Wise, Louise Dawson, Julie Ditchfield, Amir Al-Samarraie, Annette Bolger, Llinos Davies, Aileen Flavin, Jane Heron, Faye Hughes, Kim G. Jackson, Joanne Lewis, Rachel Manley, Charley-Anne Rutter, Nick Smith, Vaiku Srinivasan, J. Stockport, Heather Thomas, Hamid Toussi, Cathryn Wood, Simon Archer, Joanne Fletcher, Helen Ginnelly, Amy Kirkby, Victoria Knight, Tara Lawrence nee Palmer, Beverley Mashegede, Karen Metcalf, Miguel Panades, Thiagarajan Sreenivasan, Kinga Szymiczek, Isobel Thomas, Anita Young, Eve Broadley, Sue Brock, Joseph Davies, Stephanie L. Jones, Ruby McCully, Nicky Naraine, Kate Preece, Laura Purandare, Taslima Rabbi, Sarah Savage, Luke Vamplew, Linda Bamford, Richard Benton, L.A. Cotterill, Hayley Inman, Louise Karsera, Anne Kay, Lucille Kenyon, Jannika Lazarte, Chandran Nallathambi, Deirdre Naylor, Lisa Owen, Shefali Parikh, Amy Pendrill, Joanne Price, H Robertshaw, S. Rodda, Jane L. Sewell, Mark Teo, E. Waldron, David Bloomfield, Tracy Blythe, Philippa Carr, Carla Chambers, Jessica Dlodlo, Paul Frattaroli, Duncan C. Gilbert, Andrew Hart, Samantha Hodges, Simon Hooper, Catherine Hunter, Ranee Lactao, Madalena Leitao, Fiona McKinna, Ashok Nikapota, Jane Peterson, Angus Robinson, Jean Tremlett, Andrew Webb, Marie Wilkins, Bobbie Young, Amit Bahl, Matt Baxter, Dawn Bowers, Amarnath Challipalli, Marc Coe, Sue Cowley, David Gillatt, Dorothy Griffiths, Verity Henson, Serena Hilman, Robert D. Hollister, Mary C. Kisanga, Vivienne Lee, Amelia Lowe, Rhiannon Macefield, R. Pegler, Peter A. Robertson, M. Simmonds, Laura Sims, L. A. Wheeler, Paula Wilson, Martin Woods, Sue Yarrow, Sarah Zelley, Mohamed Abd Alazeez, Kate Alderton, Carol Brain, Helen Chilcott, Samantha Clarke, Marta Cobos-Arrivabene, Helen Corderoy, Rebecca Cousins, Victoria Garner, Chris Herbert, Lyndsey Johnson, Kathryn Jones, Gail Kemp, Sarah L. Kirkby, Suriya Kirkpatrick, Anthony Koupparis, Courtney Manning, Jon Oxley, Emily Perry, Kerry Richmond-Russell, Edward Rowe, Luke M. Shelton, Constance Shiridzinomwa, C. Smith, Ann Treasure, Clare Wyatt, K Beesley, Richard Benson, E. F. Couch, Sue Foxwell, Vanessa Goss, Juliette Harnwell, Luke Hughes‐Davies, Vicky Joslin, Angelique Laubscher, Danish Mazhar, H. D. Patterson, Sanjay Raj, Ramya Ramanujachar, Y. Rimmer, Nicola Robinson, Simon Russell, Matthew J. Stone, Robert L. Thomas, Jo Treeby, Kathryn R. Vickery, Cathryn Woodward, Ilyas Ahmed, Bonny Appleby, Patryk Brulinski, Julie Buckley, Natalie Catt, Helen Coppins, Sister Denise Crawford, Julie-Ann Davies, Susan Drakeley, Clary Evans, Joao R Galante, Louise Gladwell, Jessica Gough, Carolyn Hargreaves, Gemma Hegarty, Laura Kehoe, Rachel Larkins, Margaret Lipsham, Jessica Little, Rohit Malde, Sharon Middleton, Christos Mikropoulos, Arafat Mirza, Natasha Mithal, Kannon Nathan, Alice Rendall, Karen Jeong Robinson, Rachel Ryan, Van Sim, Michelle Swann, L Tasker, Katy Taylor, Carys Thomas, Ioannis Trigonis, Karen Walker, Joanne Williams, Elizabeth M. Williamson, Marian Wood, Pauline J. Wood, Hilary Zurakovsky, Elizabeth Bois, Hin Fan Chan, Loveness Chikopela, Helen E. Clark, Colette Clements, Samantha Holliday, Owen Hughes, Clare Jones, Malcolm Mason, Krishna Narahari, Kevin Pearse, John Staffurth, Mandy Austin, Christian Barnett, Sister Tracey Camburn, Elizabeth Dawson, Sian Gibson, Abdel Hamid, Kiran Kancherla, Priscilla Leone, Lauren Perkins, Valerie Ramsay, Bryan Singizi, Julie Allen, Susan M. Anderson, Eleanor Andrews, Rehana Bakawala, Sarah Beazer, Colin Binks, Jo Bowen, Barbara Broomfield, Audrey Cook, Christopher M. Ford, Janet Forkes, Julia Hall, Jennifer Healey-Mariano, Peter Jenkins, Nigel R. Johnson, Sai Jonnada, Roger G. Owen, Elaine Pratten, Rachel Sayers, Chris Shimell, Amy Skelton, Matthew Tan, Kate Trigg-Hogarth, Sue Wronski, Mary Aldous, Denise Archer, Helen Eccleson, Elizabeth Gallimore, Sue Green, Azman Ibrahim, Carys Jones, Jude Prince, M Chrystal, Omar Din, Alexandra G. Firth, Nicky Ford, Peter Kirkbride, John Martindale, Alison Redfearn, Janine Smedley, Lucy Smith, Vittoria Sorice, Lesley Stevenson, Julie Toms, Sister Kim Wood, Nyssa Barke, Devy Basu, Lorna Dewar, Celine Driscoll, Liz Hunting, Muthar Kumar, Louies Mabelin, Bruce Sizer, Lucy Thorogood, Sarah Askew, Jane Broom, Emma Duley, Elizabeth Firth, Aaron Gould, Christopher Hocking, Louise Johns, E. Kent, John Madine, Kerena Partridge, Corrine Penhaligon, C Pentecost, Kay Pollard, Melissa Poultney, William Pynsent, Johanna Skewes, Anita Steele, Alastair Thomson, Alice Topps, Luke Townley, Duncan Wheatley, M. D. Brown, Marie Connor, Sue Elwell, Kerry Geraghty, Theresa Griffiths, Lesley Hayward, Caroline Humber, Yakhub Khan, Sister Judith Lake, Rosaleen Laverick, Gemma Mansell, Albert Mislang, Su Ngwenya, K.E. Sanders, Elaine Simmons, Melanie Sinfield, Laura Stanley, Emily Steventon, Andrew Stockdale, Manju Sunny, Manreet Thind, Fiona Tranter, Medy Tsalic, Vanessa Adamson, Carole Bennion, Jenny Butler-Barnes, Adele Hough, Chris Hough, Joanne Hughes, Paul Irwin, P. Javlé, Carolyn Mansfield, Rachel Smith, Lesley Sumner, Annabel Tomlinson, Anna Tran, Caroline Walker, Prabir Chakraborti, Prantik Das, Dawn Ennis, Sue Marriott, D. Muthukumar, Pugazhenthi Pattu, Colin Ward, Mymoona Alzouebi, Barbara Burlace, Catherine Ferguson, Georgia Hooton, Nicole Jeffcutt, Amy Neal, Carmel Pezaro, Virgil Sivoglo, Jennifer Taylor, Nicola Wilkinson, Naveed Afzal, Beverley Anderson, Stephen Andrews, Piet Bakker, Sally Breakspear, Andrew Cornaby, Perric Crellin, Andrew Gibbins, Jackie Gibbins, Tracy Glen, Josie Goodsell, Sarah Horton, Sally Love, Benjamin Masters, Andrew Rees, Simon Sharpe, Kate Taylor, Suzy Wignall, Sister Kath Harrow, L. Ralph Jones, Karen Kanyi, Pek Keng-Koh, Karen McGarry, Prakash Ramachandra, Angela Watts, Shelley Baumber, Joanna Howard, Kay Jones-Skipper, Caroline Manetta, Lauren McCrisken, Joanne Taylor, Amanda Williams, Alison Clark, Maria Clarke, Lisa Egan, Kathleen Fiddes, Susan Forman, Fiona Gardiner, David Jeffrey, Param Mariappan, Barbara Mayne, Duncan McLaren, Brian Rogers, C. G. Woods, Douglas Young, John Anderson, Kizzy Baines, Malcolm Crundwell, Elizabeth Davey, Theresa Lawless, E Matkins, Shannon Mcginley, John McGrath, Jane Piper, Alison Roantree, Ingrid Seath, Rajaguru Srinivasan, M. STOTT, Katie Timmings, Claire Webb, Abdulla Alhasso, Lorraine Barwell, D. Dodds, Niall Finnegan, Ailsa Griffen, Rob Jones, Claire Lawless, Antonia MacMillan, Martin Russell, Azmat Sadozye, Sian Shirley, Norma Sidek, Jan Wallace, Naeem Akhtar, Karen Bell, Louise Humpreys, D. B. McWilliam, Emma Moody, R. G. O'Neil, Suzannah Peck, Raidah Auladin, Stephanie Bird, Caterina Bissa, M. Dabbs, Fabio Di Maria, Joshua Harding, Ceri Jamieson, J.Stephen Jones, Sara Khaksar, Robert Laing, Laura Matthews, Aruna Medisetti, Barbara Molony-Oates, Julian Money‐Kyrle, Jenny Nobes, Weronika Rabsztyn, Frances Sidi, Daisy May Smale, Sarah Stone, A. Tindall, Jane Woods, Min Wu, Amelia Daniel, Evelyn Holmes, Joanne Kellaway, Amanda Lewis, Teresa Light, Lucinda Melcher, Lily Robinson, Nikki Staines, S. Carini, Sophie Cooper, Melanie Evans, Josh Follows, Warren Grant, Andy Hedges, Claire Hughes, Janine Jones, Lisa R. King, Laura Lees, Lily Mercer, S. Terence Myles, Zara Roberts, Nicola Williamson, Sara Abbassi, Roberto Alonzi, N. Anyamene, Julia Bici, Lucy Collins, Jeanette Dickson, Sandra Garrido-Perez, Robert C Hughes, Suzanne Jenkins, Paulina M. Kowalewska, Jessica Milner, Lesley Mitchell, Peter Ostler, Aamna Rashid, Stephanie Stapleton, Linzi Bone, Diane Clark, Sanjay Dixit, Rhian J. Horne, Dawn Jones, Sarah Palmer, Kristian Plowman, Julie Rawlings, Matthew Simms, Anglise Addison, Seonaid Arnott, Sudhir Borgaonkar, Sandra Brown, Audrey Campbell, Steve Colligan, Margaret A. Cormack, Victoria Doughty, Kay Kelly, D. Lister, Alison Macdonald, Carol MacGregor, Rachel K. MacKay, Jude Madeleine, Morag McNally, Neil McPhail, Sean Neville, A. J. Nicholls, A. Papakostidi, Georgina Simpson, G. Sinclair, A. Skene, Sheena Telfer, Zoe Urquhart, D. Whillis, Charlotte Etheridge, Amanda Ford, Paul Ridley, Christopher Scrase, Susan Upson, Ramachandran Venkitaraman, Lisa Capaldi, Mark Churn, Linda W. Higgins, Helen Knott, Sally E. Stringer, Jacob Taylor, Helen Tranter, Julie Wollaston, Stephanie Brogan, Susan Erskine, M Hamill, Lynn Prentice, Lesley Symon, Seamus Teahan, Anne Todd, James Tweedle, Sally Young, Gemma Austin, Ian S. Boon, Edmund Breckin, Jude Clarke, Catherine Coyle, Emily Davies, James Goulding, Anne E. Kiltie, Carmel Loughrey, Fatima Murad, Claire Pratt, Beccy Smith, G. M. Smith, Amy Branson, Sallyanne Christmas, Jill Cooke, T.R. Leyshon Griffiths, Christopher Kent, Amy King, Roger Kockelbergh, Janet Potterton, Lesley Speed, Subramanian Vasanthan, Julia A. Walker, Karin Baria, Samantha Bateman, Sarah Coombs, Amy Cunningham, N. Dahar, Pallon Daruwala, Olesya Francis, Jane Hall, Kathryn Hoare, Claire Key, Carol Lockwood, Ian T. Mark, Rachel Newton, Andrew Sloan, Nicola Bermingham, Lynsey Dean, Zafar Malik, Peter Robson, Heather Rogers, Thomas R. Rogers, Katy Treherne, A. R. Bourke, Bindu Chikkamuniyappa, Ross Dalton-Short, Steve Edwards, Alison Falconer, Amy Ford, Sathish Harinarayanan, Nebah Hassan, Gillian Hornzee, Sophia Magwaro, Bhavesh Pratap, Sarah Rezkallah, Ibiyemi Sadare, May Stancliffe, Simon Stewart, Anne-Maree Thoi, Anna Westrop, Sheefa Ahamadali, Nasr Arsanious, Shaki Balogun, Cheryl Batish, Yvonne Campbell, Claire Crowley, Emma Dunne, Miguel Godinho Ferreira, Anne Haldeos, Adham Hijab, Robert Huddart, Babbin John, Andriana Michaelidou, Mohammed Nawrozzadeh, J Pach, Priyanka Patel, Ann Payne, Matthew Perry, Maria Serra, Christine Springall, Jane L. Thompson, Sister Jane Thomson, Viviana Aya, R. P. Beaney, L. Bower, Lisa-Jane Conway, S. F. O'B. Donaghey, Hussain Gordon, Isabel Ariño Grau, Sarah E. Harris, Vesna Hogan, Brendan Hore, Simon M. Hughes, Katie Jones, Greg Kuenzig, Dawn Nunney, Philip A. Reynolds, Bali Rooprai, Stephen Mangar, Hanna Azirar, Tom Caumont, Nishi Gupta, Stephen E. 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Murphy, Kirsty Beaton, Nanette Bech-Nielsen, Olivia Bolton, John Conibear, Fatjon Dekaj, Paul Hillman, Alexandre Kaliski, Janet Kiff, Alastair Nicholson, Jude Nixon, Janet Oladimeji, Oscar Riches, Daniel Smith, Karen Tipples, Paula Wells, Chris Anderson, Deirdre Daly, Serena Dover, Claire Gilmartin, Sophie Golden, Jane Gregg, Rami Issa, Titilayo Oni, Chandni Patel, Mark Quarrell, Debbie Rolfe, Helen Tighe, Jesusa Toledo, Juel Tuazon, Robert Varro, Vikram Bohra, Mark Caballes, Laura Custins, Stephanie Ivie, Manisha Joshi, Joy Liau, Farhan Naim, Anup Patel, Byiravey Pathmanathan, Emily M. Russell, Anna Tippins, Didem Agdiran, Ajay Aggarwal, Thomas Amoaten, Natasha Aslam, Nicole Bonsu, Zainab Butt, Patricia Danaswamy, Reena Davda, Annelies Gillesen, Roshni Goel, Rachel Khong, Suzy Lowi, Richard L. Merrick, Anita Mitra, Heather Payne, Jonathan Teh, Samantha Whinn, David Woolf, Helene Zilkha, Linda Dawson-Athey, Emma Foster, Andrew Gillian, James Green, John Hines, Simon Holden, Memory Kazingizi, John O’Neill, Thompson Olaoni, John Peters, T. Philp, Sadaf Zaidi, Adebanji Adeyoju, Victoria Adinkra, Richard Brough, Stephen CW Brown, Gerald N. Collins, Lisa Hardstaff, Pippa Hill, Magda Kujawa, Marilyn McCurrie, Barbara Townley, Iain Woodhouse, Waheed Zafar, S. Beesley, Vivienne Breen, Su Burrage, Clare Calvert, Alison Davison, Heather Dias, Gavin Fossey, Jodie Hotine, Ifan Jones, Carmel Jope, Yvonne Lines, Sarah Martins, B Mercier, Jane Murray, Innocent Neshiri, Ian Pamphlett, Ann Phillips, Pavnish Rai, Verity Roberts, Henry F. Taylor, Lisa Tribe, Ian Bottomley, J Buchan, Viviana Carpio, Ruth Conroy, Richard Cowan, Sue Davison, Ian D. Duncan, Tony Elliott, Kim Fair, Adrian Fallaize, Laura Flanagan, Sarah B. Green, Catherine Harris, Amber Hart, Cathryn Jones, Jacqueline E. Livsey, Damian McCaul, Roonak Nazari, Carol Newbery, Kate O’Connor, Sister Jackie O'Dwyer, Joanne Oliver, Ekugbe Onoge, Maria Petsa, Catherine Redshaw, Sarah-Ellen Smith, Willemijn Spoor, Sister Viv Thomas, H.J.O. White, Lucy Worsley, Linda A. Bailey, Molly Bennett, Rebecca Corless, Annie Duffy, Kathryn Fellows, Anna Gipson, Helen Haydock, W.F. Knox, Sarah Liptrott, Fiona McCarth, Fiona McCartin, Heena Mistry, Thobekile Mthethwa, Lillian Partington, Lindsay Piper, Vijay Ramani, Sarah Sahin, Vijay Sangar, Kathryn Slevin, Jonathan Tuck, Lorraine Atkinson, Sarah Barnbrooke, Alison C. Barnes, Caroline Brownless, D. J. Chadwick, John Hardman, Keith Harland, Carol A. Long, Sarah McAuliffe, Julia McBride, Sister Patricia McClurey, Rita Mohan, Lynne Naylor, C. Peedell, Paula J. Robson, Devadasan Shakespeare, Emma Thompson, H. van der Voet, David J. Wilson, Chris Barron, J. Frew, Katy Lambert, R. McMenemin, Ian Pedley, Danielle Riseborough, Trevor Roberts, E Stockley, Jonathan Stoddart, Janine Tate, J. PATRICK WALKER, B. S. Workman, Debra Barnett, Adam Carter, Adam Cox, Alison Davey, Kirstin Davies, L. J. GILBY, Simon Hodge, S Kearney, Helene Lavender, Janet Marty, Maxine Nash, Syhed Rahman, Jayne Richards, J. A. Simpson, Elaine Wall, Paula Webb, Karen Wild, Jim Wilson, J. P. Branagan, G. Dell, M. Foo, Ruby Goyena, Andrea Jones, Hazel McBain, Katherine McGrath, J P O'Callaghan, Dorai Ramanathan, Elizabeth Tee, Bronwen Thominson, Rachel Tighe, Jane Beety, R W P BIRCH, Mark Bloomfield, Sara Callam, Adele Cooper, H. Darby, Gail Healey, Karen Heasley, Guarav Kapur, Clare London, Katrien Oosterom, J. Ostrowski, Bridget Shobrook, Sarah Turner, Rob Wade, Suzanne Walker, Sharon Walton, Cheryl Websdale, Joanna White, Leanne Alder, Rachael Chivers, Carol Gooch, Lucy Howard, Camille Hutchinson, Cody Jevons, Daniel Kumar, Hazel Marley, Jamie Mills, Hanna Purves, Ian Sayers, Santhanam Sundar, Jacob Szolin-Jones, Georgina Walker, Catherine Wood, Wendy L. Cook, L. M. Gill, Joanne Johnson, Dawn Johnstone, Richard J. Jones, Leena Mistry, Lyndsay Scarratt, A Aiku, Daniel Ajzensztejn, H. Al-Chamali, Gerard Andrade, Sylwia Bekulart, Gagan Bhatnagar, J. Boutflower, Simon Brewster, Anne Butterfield, Weronika Carroll, David J. Cole, T. J. Coutts, Kerrie Doyle, Lisa Durrant, Trish Green, Raj Jampana, Patrycja Jastrzebska, Phillippa Kyffin, Nicole Langridge, Sarah Lawrey, Kerrie Marston, Matthew Mooney, Sandra Mukkath, Ann Murphy, Rob Owens, Sarah Ruane, Ahmad Al Sabbagh, Grace Samkange, Naveen Sankighatta, Michael Skwarski, Robert K. Stuart, Sandie Wellman, Jo Ellen Wilson, Kerrie Cavanagh, A.E. Hollingdale, Susan Hannah Allen, Elisa Barter, Debbie Gregory, Charlotte Ingle, Steph Lawrence, Paula-Joanne Rooney, Emma Bishop, Maria Brennan, J. C. HAMMONDS, Paul McInerney, Esther McLarty, S Natale, S. Pascoe, Keith Purcell, Henry Sells, Sharah Tyner, Victoria yates, N. G. Beamish, Hilary Blaney, Felicity Clapp, Elizabeth Clarke, Teresa Coffin, Joe Davies, Nichola Downs, Sally Gillespie, Louise Heckford, Amanda Iskender, Sara Orford, Sandy Pressdee, Sophie Rix, Roger Wheelwright, Elizabeth Woodward, Seonaid Wright, Kathy Blight, Tracey Dobson, Jennifer Hale, Angie Harris-Burland, Ghassan Khoury, K. B. Madhava, Lorna Meadows, Yoodhvir Nagar, Mila Roca, Wendy Stacey, Anna B. Stephenson, Maja Uherek, Azarel Virgo, Catrin Watkinson, Alison Birtle, Z. Chauhan, Stephanie Cornthwaite, Sandra Curtis, Rose Ellard, Nathan Fish, Billy Hefferon, Claire Searle, Helen Spickett, Catherine Walmsley, Jane Monnig Atkinson, Richard B. Brown, Debbie Cartwright, Kristy Coomber, Allison L. Hunt, Wioletta Kowalczyk-Williams, Christina Lewis, Stephen Parr, Helen Purdon, P. Rogers, Emma Vowell, Wendy Featherstone, Joanna M. Hamilton, Alison Harrison, Margaret Hindle, H. H. Hodson, Andrea Isaew, Jeanette Knapp, Sarah Moss, Stephanie Gibbs, Sandeep Gujral, Revanth Jannapureddy, Anand Kelkar, Maria Martinou, Tina Mills‐Baldock, Neale O’Brien, Subramaniam Ramachandran, Saad Tahir, Mohammad Tanvir Vandal, Thi Vu, Rachael Allen, Chris Betts, Amanda Bowmer, Amanda Cordwell, Soney Dharmaprasad, Claire Duncan, Christine Farnworth, Helen E. Farrell, Siny George, Kay Goulden, Leah Harter, Sister Sarah Kirk, Maurice Lau, Anne Marie Lydon, Kieran O’Flynn, Danielle Platt, David Shackley, Garry Stevenson, Sister Melanie Taylor, Cellins Vinod, Oliver Wadsworth, Sister Jill Youd, Julie Attlee, Adityanarayan Bhatnagar, Sarah Bunn, Allister Campbell, Mohammed El-Saghir, Ruth Fennelly, Peter Guy, Lehentha Mattocks, Gregor Mcintosh, Brenda Murphy, Catherine L. Reed, Sophia Strong-Sheldrake, Gemma Tedd, Kathleen Dent, Sanjay Dixit, Marion Hood, Karen Martin, Sandra Pearson, Dorota Potoczna, Sue Spencer, Jo Towse, Nikita Whotton, Katie Bowen, Su Clark, Rachael M. Clarke, Kate Gibbins, Jackie L. Martin, Suzanne Smith, Catherine Spalton, Jessica Tay, Marion Adams, Emma Bates, Indukala Chennattukungu, Joanna Clancy, Vanessa Cross, Hayley Hughes, Sanal Jose, Sunita Kurian-Downer, Elena Michael, Sister Helen Moore, Karen Nicholas, Suzanne Pope, Sally Potts, Ravi Prashant, Harpreet Singh, Sandra E. Smith, Narayanan Srihari, Emma Weaver, Ali Abbas, Nicky Barnes, Nicola Dallas, Sister Ann Jackson, Nicole Kader, O. Karim, Marc Laniado, Jayne Litchfield, Sana Mahmood, Helen O’Donnell, Victoria Robinson, Alison Sears, Shahid Sharif, Ana Sierra Pala, Julie-Ann Sinclair, Sister Catherine Smith, Jan Ashcroft, Jeanette Bowes-Cavanagh, Rebecca Brown, Alison Chedham, Flora Darch, Michelle A. Farrar, Jayne Foot, Simon Goldsworthy, John D. Graham, Emma Gray, Sara Green, Joseph Jelski, Odunayo Kalejaiye, Manjusha Keni, Angela Locke, Sue Mahoney, Faith McMeekin, Manivannan Periasamy, Tamlyn Russell, Elizabeth Ruszala, Surayne Segaran, Mary Ann Tighe, Rebecca Wallbutton, Christine Webster, Alison Whitcher, M Wrigley, Maria Zietz, Julie Abab, Kirsty Cumming, Lucy Galloway, Malavika Ganabady, Annelise Haskell, Catherine Heath, Naomi James, Julie Kennedy, Victoria McFarlane, Fabiola Morales-Azofra, Susan Morton, Carina Mundy, Mark Noble, Alec Paschalis, Julie Hicks Patrick, Leanne Reader, Lisa Taylor, Shauna Wakefield, Imtiaz Ahmed, Sue E Bowman, Olivia Chan, Abby Cyriac, Tracey Davies, Katrina Maitland, Jan Prejbisz, Sheila Reece, Heather Shires, David Tsang, E. Anscombe, WA Brough, Pat Clitheroe, Tracie Cocks, Sarah Connolly nee McKenna, Sam Corcoran, Tricia Coughlan, C. C. B. Gilmour, Emma Goodwin, Susan Graham, Umi Hatimy, S Hodgkinson, John Kilmartin, Lucy Orrell, Carol Rotherham, Sarah Smallwood, Jill Taylor, Elliott Wiss, F. Adab, Rajanee Bhana, Kathirvelu Dhinakaran, Marion W. Evans, Alison Myatt, Katrina Parkinson, Angela Peake, Elizabeth A. Sellars, Rowena Smith, J. B. Storer, Georgia Thomasson, Salil Vengalil, Jenny Walton, Angela Ward, Samantha Boam, Jamie-Rae Burgoyne, E. Chadwick, Shafiq Gill, Steve Haigh, K. E. HOLLIS, Jun Hyeok Lim, Alastair McCabe, L J Munson, Dominic Nash, D.J. Saunders, Susan Smith, Lynne Wade, Elizabeth Evans, Alex Franklin, Emily Harris, Maria Johnstone, Lewis Jones, Nicola Lemon, Mau-Don Phan, Delia Pudney, Rachael Spence, Alison Stretch, Ellen Tait, Rebecca Belcher, Shiroma De Silva-Minor, Sister Jan Dodge, Sarah Grayland, Ania Jones, Omar Khan, Tim Owen, Cerila Parajes, Suzannah Pegler, Abbie Poole, Sister Tracey Sargent, Ellen Starling, Becky Taylor, Sister Helen Winter, Vivian Zinyemba, Michele Allison, Catherine Brookman, Jonathan D. Buckley, Shelley Chamberlain, Donna Cuffe, Stacey Davies, Helen Greedus, Hannah Griffin, Ingrid Koehler, Anna Lydon, Jorg Michels, Julia Pym, Fiona Roberts, Lorraine Thornton, Elaine Vandecandalaere, Erica Watts, Linda Welsh, Jim Anderson, Julie Ball, Louise Benton, Richard Bowers, Rohit Chahal, Peter Dickinson, C. Fosker, Janine Heeley, Subramanian Kanaga‐Sundaram, S. Littler, Jonathan C. Slack, S.K. Sundaram, Beverley Taylor, Philip Weston, Judith Chettle, Lyn Hartwell, Ashley Johnson-Rollings, Julia Jones, Helen Millage, Eilish O'Neill, Donna Walsh, Kerrie Webb, Jo Williams, Harvey Dymond, Symeon Eleftheriadis, Hugh Lloyd-Jones, Tom Wells, Sarah Bennett, Sharon Dunn, Diane Fildes, Alison Hassall, Gaynor Herbert, Kathryn Hughes, Helen Innes, Alison Kelly, J.A.H. Littler, L Lomax, Nikki Miller, C A Nutman, Matthew B. Stott, Isabel Syndikus, Shaun Tolan, Alison Weston, Ivanna Baker, Vanda Carter, Jenny Chatfield, Peter Cooke, Anna Grant, David Homer, Christine Kirk, Claire Lomas, Marian McCormick, Arizoo Mohseeni, Renita Pawaroo, Liz Radford, Jason Rogers, A. 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Rattachement africain : gb, ca, dk. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear. METHODS: RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047. FINDINGS: Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61-69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1-10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688-1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4-82·5) in the no ADT group and 80·4% (76·6-83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths. INTERPRETATION: Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population. FUNDING: Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial
- Date Crossref
- 01/06/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.