Isabelle Gauthier

Treatment outcomes for oropharyngeal cancer: findings from an institutional study

C Wang, Jérôme Costisella, Benoit Emond-Guilbert, Isabelle Gauthier et autres

Introduction: Locally advanced oropharyngeal squamous cell carcinoma (OPSCC) represents a growing clinical challenge, primarily due to the increasing incidence of human papillomavirus (HPV)-associated disease. While treatment options include radiotherapy (RT) alone, RT with Cetuximab (RCX), or radiochemotherapy (RCT), the latter remains the …

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Development of metastases in mice induced by plasma sample collected during radiotherapy in patient with triple-negative breast cancer: Role of Rab4A

Benoît Paquette, Hélène Therriault, Isabelle Gauthier, Sawyna Provencher et autres

ABSTRACT The relapse rate in early-stage triple-negative breast cancer (TNBC) is significantly higher than in other breast cancer subtypes. This study assessed the relevance to target RAB4A to prevent the development of metastases that occur after treatment. The ability of cancer cells …

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Pediatric Spine Ultrasound: Comprehensive Review and Systematic Approach

Neetika Gupta, Shivaprakash B. Hiremath, Isabelle Gauthier, Nagwa Wilson et autres

Ultrasound (US) is an invaluable tool for evaluating the neonatal spine, offering a non-invasive, cost-effective, and radiation-free imaging alternative. This article reviews the indications, techniques, and sonographic features of congenital and acquired spinal pathologies in neonates. Common indications include the evaluation of …

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Pediatric Neurosonography: Comprehensive Review and Systematic Approach

Neetika Gupta, Shivaprakash B. Hiremath, Isabelle Gauthier, Nagwa Wilson et autres

Neurosonography (NSG) is pivotal for rapid, point-of-care neonatal brain assessment. This review elucidates the comprehensive applications of NSG in pediatric care, emphasizing its role in early diagnosis and management of pathologies affecting the pediatric head-such as scalp lesions, misshapen calvarium, ventricular distortions, …

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Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial

Chris Parker, Noel W. Clarke, Adrian Cook, Howard Kynaston et autres

BACKGROUND: Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear. METHODS: RADICALS-HD was …

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173 Plasma Collected During Radiotherapy in Triple-Negative Breast Cancer Patient Stimulates Development of Lung Metastases in a Mouse Model

Benoît Paquette, Hélène Therriault, Isabelle Gauthier, Sawyna Provencher

CCTG HN11: SPECT-CT guided elective contralateral neck treatment (SELECT) for patients with lateralized oropharyngeal cancer—A phase III randomized controlled trial.

John R. de Almeida, Wendy R. Parulekar, Apostolos Christopoulos, Isabelle Gauthier et autres

TPS6114 Background: Lymphatic mapping identifies neck lymph nodes at risk for cancer spread in patients with lateralized oropharyngeal (OPC) squamous cell carcinoma. We hypothesize that a lymphatic mapping guided approach to radiotherapy (RT) treatment of the contralateral neck will enable safe de-escalation …

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A phase IB study of durvalumab with or without tremelimumab and platinum-doublet chemotherapy in advanced solid tumours: Canadian Cancer Trials Group Study IND226

Rosalyn A. Juergens, Desirée Hao, Dongsheng Tu, Mihaela Mates et autres

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Preoperative and Surgical Risk Factors for Complications Requiring Sling Revision or Removal after Midurethral Sling Procedures: a Case-Control Study

Aisling A. Clancy, Isabelle Gauthier, F. Daniel Ramirez, Duane Hickling et autres

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Chronic mild stress exacerbates severity of experimental autoimmune encephalomyelitis in association with altered non-coding RNA and metabolic biomarkers

Brietta Gerrard, Vaibhav Singh, Olena Babenko, Isabelle Gauthier et autres

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Outcomes of intensity-modulated radiotherapy versus conventional radiotherapy for hypopharyngeal cancer

Gary Mok, Isabelle Gauthier, Haiyan Jiang, Shao Hui Huang et autres

BACKGROUND: The purpose of this study was to discuss if the adoption of intensity-modulated radiotherapy (IMRT) for hypopharyngeal squamous cell carcinoma (SCC) has improved the outcome. METHODS: We compared 3-dimensional (3D) radiotherapy (RT) and IMRT in all patients with hypopharyngeal SCC treated …

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Patient perceptions of multiple sclerosis and its treatment

Isabelle Gauthier, de Sèze, Brudon

BACKGROUND: In order to improve the treatment outcome in multiple sclerosis, it is important to document the factors that influence adherence to therapy. The purpose of this study was to determine patient perceptions and awareness of multiple sclerosis and its treatment, treatment …

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