Adham Hijab

Surgery After Induction Therapy for Cervical Esophageal Cancer: A Systematic Review and Proposed Multidisciplinary Selection Framework

Ismaell Massalha, Adham Hijab, Reem Zabit, Bilal Krayim et autres

Background/Objectives: Management of cervical esophageal cancer after induction therapy remains unsettled. Definitive chemoradiotherapy is the guideline default, but a subset of patients with residual but resectable disease may still benefit from surgery. No validated multidisciplinary selection framework exists for this subsite. Methods: …

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Prognostic Impact and Postoperative Management Following Poor Pathological Response to Perioperative FLOT in Resectable Gastric and GEJ Adenocarcinoma: A Systematic Review and Meta-Analysis

Ismaell Massalha, Reem Zabit, Samer Hussany, Adham Hijab et autres

Background: Pathological tumor regression is a key prognostic marker in resectable gastric and gastroesophageal junction (GEJ) adenocarcinoma. Perioperative FLOT (fluorouracil, leucovorin, oxaliplatin, docetaxel) established the modern treatment backbone, and the recent MATTERHORN trial further intensified this paradigm with the addition of durvalumab. …

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205eP The role of variant allele frequency in EGFR-mutated NSCLC patients in response to osimertinib

Walid Shalata, B. Krayim, Yulia Dudnik, A. Cohen et autres

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Stereotactic body radiotherapy for prostate cancer with urinary structures sparing utilizing online CT-guided radiotherapy: A feasibility and early outcomes study

Adham Hijab, Shlomi Alani, Y. Tova

Plasma AR Alterations and Timing of Intensified Hormone Treatment for Prostate Cancer

Gianmarco Leone, Francesco Orlando, Peter Dutey‐Magni, Osvaldas Vainauskas et autres

This randomized clinical trial explores whether hormone intensification at start of androgen deprivation therapy alters selection of androgen receptor (AR) gene alterations within the gene body and/or enhancer region.

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PSMA PET-CT Imaging of Radiation-Induced Lung Injury from Vertebral Radiotherapy

Stephanie Mantzur, Shlomi Alani, Adham Hijab, Maayan Geller Hinitz et autres

Radiation-induced lung injuries (RILI) are a notable complication of thoracic radiotherapy, significantly affecting the quality of life and prognosis for cancer patients. We present the case of a 68-year-old man with metastatic prostate cancer who underwent radiation therapy for a metastatic thoracic …

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CT-Guided Online Adaptive Stereotactic Body Radiotherapy (SBRT) for Retroperitoneal Sarcoma After Previous Radiotherapy: A Case Report

Adham Hijab, Y. Tova, Shlomi Alani, Sharon Amitzur

CT-guided online adaptive radiotherapy (OART) is a novel and robust treatment technique in radiotherapy. Thanks to its excellent accommodation of inter-fraction variations, OART is characterized by superior accuracy compared to other contemporary treatment techniques in radiotherapy such as image-guided radiotherapy (IGRT). Planning …

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The Right Gastroepiploic Artery as a Potential Organ at Risk in Neoadjuvant Chemoradiation for Esophageal and Gastroesophageal Cancers

Adham Hijab, Y. Tova, Shlomi Alani

BACKGROUND: Preoperative chemoradiation is a standard of care for esophageal and gastroesophageal cancer. A gastric conduit is usually used for anastomosis with the right gastroepiploic artery (RGEA) being the sole arterial supply to the gastric remnant after such surgeries. Hence, lowering the …

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Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial

Chris Parker, Noel W. Clarke, Adrian Cook, Howard Kynaston et autres

BACKGROUND: Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear. METHODS: RADICALS-HD was …

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Acrofacial vitiligo secondary to PI3KCA inhibitor, alpelisib: case report

Adham Hijab

Alpelisib plus fulvestrant is a valid second or advanced line of treatment for patients with metastatic hormone receptor (HR)-positive, HER2-negative breast cancer who harbor an activating PIK3CA mutation. The well-known side effects of alpelisib are hyperglycemia, rash, and diarrhea. Herein, we report …

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Dosimetric comparison of automatically propagated prostate contours with manually drawn contours in MRI-guided radiotherapy: A step towards a contouring free workflow?

Kobika Sritharan, Alex Dunlop, Jonathan Mohajer, Gillian Adair-Smith et autres

Background: The prostate demonstrates inter- and intra- fractional changes and thus adaptive radiotherapy would be required to ensure optimal coverage. Daily adaptive radiotherapy for MRI-guided radiotherapy can be both time and resource intensive when structure delineation is completed manually. Contours can be …

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The evolving treatment paradigm of locally advanced rectal cancer: a narrative review

Muhammad Awawda, Tarek Taha, Saeed Salman, Salem Billan et autres

Background and Objective: Surgery is still considered the mainstay of treatment of locally advanced rectal cancer (LARC). Nevertheless, "curable" disease may still pose a great risk for both local and distant relapses. Since the early eighties of the past century, we have …

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