Katy Taylor

Plasma AR Alterations and Timing of Intensified Hormone Treatment for Prostate Cancer

Gianmarco Leone, Francesco Orlando, Peter Dutey‐Magni, Osvaldas Vainauskas et autres

This randomized clinical trial explores whether hormone intensification at start of androgen deprivation therapy alters selection of androgen receptor (AR) gene alterations within the gene body and/or enhancer region.

gb, it (code pays fourni par la source)

Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial

Chris C. Parker, Noel William Clarke, Adrian David Cook, Howard Kynaston et autres

BACKGROUND: Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear. METHODS: RADICALS-HD was …

gb, ca, dk (code pays fourni par la source)

Reversing the Friday peak in metastatic cord compression referrals: Not as simple as previously thought?

Sola Michael Adeleke, Rubyyat A Hakim, Laurence Dean, Huma Zahid et autres

e14050 Background: Historically, metastatic spinal cord compression (MSCC) referrals trend towards a Friday peak in incidence (Koiter E, Radioth Onc 2013). However, data from a single, tertiary centre in the UK showed a reversal in the Friday peak (Adeleke S, Annals of …

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Abstract 2962: Histone H3.3 mutations drive paediatric glioblastoma through upregulation of MYCN.

Lynn M. Bjerke, Alan G. Mackay, Meera Nandhabalan, Anna Burford et autres

Abstract Glioblastomas of children and young adults (pGBM) have a median survival of only 12-15 months and are clinically and biologically distinct from histologically similar cancers in older adults. They are defined by highly specific mutations in the gene encoding the histone …

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Hypocholesterolaemia and cancer?

Katy Taylor

huge increase in participants, the public may be said-literally-to be voting with its feet.