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Genomic reconstruction of the SARS-CoV-2 epidemic in England

120Citations signalées — pas une note de qualité
100Institutions déclarées
2Pays d’affiliation déclarés

Résumé fourni par la source

The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the COVID-19 Genomics UK Consortium to reconstruct the dynamics of 71 different lineages in each of 315 English local authorities between September 2020 and June 2021. This analysis reveals a series of subepidemics that peaked in early autumn 2020, followed by a jump in transmissibility of the B.1.1.7/Alpha lineage. The Alpha variant grew when other lineages declined during the second national lockdown and regionally tiered restrictions between November and December 2020. A third more stringent national lockdown suppressed the Alpha variant and eliminated nearly all other lineages in early 2021. Yet a series of variants (most of which contained the spike E484K mutation) defied these trends and persisted at moderately increasing proportions. However, by accounting for sustained introductions, we found that the transmissibility of these variants is unlikely to have exceeded the transmissibility of the Alpha variant. Finally, B.1.617.2/Delta was repeatedly introduced in England and grew rapidly in early summer 2021, constituting approximately 98% of sampled SARS-CoV-2 genomes on 26 June 2021.

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Contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref
Genomic reconstruction of the SARS-CoV-2 epidemic in England
Date Crossref
14/10/2021
Éditeur
Springer Science and Business Media LLC
Type
journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.

Institutions déclarées

European Bioinformatics InstituteThe Francis Crick InstituteWellcome Sanger InstitutePublic Health EnglandLondon School of Hygiene & Tropical MedicineUniversity of OxfordUniversity of CambridgeCambridge University Hospitals NHS Foundation TrustUniversity of BrightonNorfolk and Norwich University Hospitals NHS Foundation TrustPublic Health WalesUniversity of PortsmouthCardiff UniversityUniversity of BirminghamKing's College LondonUniversity of EdinburghGuy's and St Thomas' NHS Foundation TrustUniversity College HospitalUniversity College London Hospitals NHS Foundation TrustUniversity College LondonUniversity Hospital Southampton NHS Foundation TrustUniversity of SouthamptonSt George's, University of LondonGreat Ormond Street HospitalMRC University of Glasgow Centre for Virus ResearchQueen's University BelfastBlackpool Teaching Hospitals NHS Foundation TrustUniversity of HullPoole HospitalUniversity Hospitals Dorset NHS Foundation TrustUniversity Hospitals Sussex NHS Foundation TrustUniversity of ExeterUniversity of NottinghamQueen's Medical CentreEast Kent Hospitals University NHS Foundation TrustNorthumbria UniversitySt George’s University Hospitals NHS Foundation TrustUniversity of SheffieldPortsmouth Hospitals NHS TrustImperial College Healthcare NHS TrustNHS Greater Glasgow and ClydeNorth West London PathologyQuadram InstituteBelfast Health and Social Care TrustHampshire Hospitals NHS Foundation TrustUniversity of KentRoyal Free London NHS Foundation TrustSouth Tees Hospitals NHS Foundation TrustPublic Health ScotlandUniversity of LiverpoolImperial College LondonMRC Biostatistics UnitRoyal Oldham HospitalBuckinghamshire Healthcare NHS TrustNewcastle upon Tyne Hospitals NHS Foundation TrustNHS LothianNIHR Imperial Biomedical Research CentreUniversity of East AngliaHeartlands HospitalBetsi Cadwaladr University Health BoardNorfolk County CouncilCentre for Human GeneticsCardiff and Vale University Health BoardUniversity of St AndrewsHarefield HospitalQueen Elizabeth Hospital King's Lynn NHS Foundation TrustWhittington Health NHS TrustUniversity Hospitals of Leicester NHS TrustBarking, Havering And Redbridge University Hospitals NHS TrustBournemouth UniversityNottingham University Hospitals NHS TrustCounty Durham and Darlington NHS Foundation TrustKettering General HospitalGreat Ormond Street Hospital for Children NHS Foundation TrustMaidstone and Tunbridge Wells NHS TrustNorth Cumbria Integrated Care NHS Foundation TrustNorth Tees and Hartlepool NHS Foundation TrustNorthern Lincolnshire and Goole Hospitals NHS Foundation TrustQueen Elizabeth Hospital BirminghamRoyal Devon & Exeter NHS Foundation TrustSwansea UniversityKing's College Hospital NHS Foundation TrustWellcome/MRC Cambridge Stem Cell InstituteBarts Health NHS TrustSheffield Teaching Hospitals NHS Foundation TrustPublic Health AgencyNorthumbria Healthcare NHS Foundation TrustEast Suffolk and North Essex NHS Foundation TrustEast Sussex Healthcare NHS TrustGateshead Health NHS Foundation TrustIsle of Wight NHS TrustManchester University NHS Foundation TrustNorth Middlesex University Hospital NHS TrustGenomics EnglandRoyal Marsden NHS Foundation TrustThe Royal Wolverhampton NHS TrustWatford General HospitalNewcastle UniversityGerman Cancer Research CenterHeidelberg University

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Sujets associés

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesPlant Virus Research Studies

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