Darren R. Murray

P61 A comparative analysis of physical control alveolar volume data between a manual calibration syringe and a ventilated syringe

Lauren Kimberley, Jessica Swan, Mark Unstead, Darren R. Murray

Introduction Recent guidance suggests a daily physical control test should be performed using a 3L syringe (ARTP, 2020). In accordance, with supplier guidance this is performed locally with a syringe with integrated ventilation.The aim of this study was to assess if physical …

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47P Investigation of XRCC1-rs25487 genotype associations with end-of-radiotherapy lymphopenia in a large observational study of Danish patients treated for one of nine cancer types

Milan Milojevic, Bruno Ledergerber, L. Specht, Ivan R. Vogelius et autres

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Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes

Seb Cotton, M. McHugh, Rebecca Dewar, J.G. Haas et autres

BACKGROUND: The first epidemic wave of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Scotland resulted in high case numbers and mortality in care homes. In Lothian, over one-third of care homes reported an outbreak, while there was limited testing of hospital patients …

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ASRgenomics: Complementary Genomic Functions

Salvador A. Gezan, Darren R. Murray, Amanda Avelar de Oliveira, Giovanni Galli

Presents a series of molecular and genetic routines in the R environment with the aim of assisting in analytical pipelines before and after the use of 'asreml' or another library to perform analyses such as Genomic Selection or Genome-Wide Association Analyses. Methods …

A large outbreak of the Kappa mutation of COVID-19 in Cork, Ireland, April–May 2021

Peter Barrett, O. Bruton, M. Hanrahan, Paul F. White et autres

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Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer

Annika Fendler, Scott T.C. Shepherd, Lewis Au, Mary Wu et autres

Patients with blood cancer continue to have a greater risk of inadequate immune responses following three COVID-19 vaccine doses and risk of severe COVID-19 disease. In the context of the CAPTURE study (NCT03226886), we report immune responses in 80 patients with blood …

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Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Brian J. Willett, Joe Grove, Oscar A. MacLean, Craig Wilkie et autres

In the version of this article initially published, the author affiliation information was incomplete, neglecting to note that Brian J. Willett, Joe Grove, Oscar A. MacLean, Craig Wilkie, Giuditta De Lorenzo, Wilhelm Furnon, Diego Cantoni, Sam Scott, Nicola Logan and Shirin Ashraf …

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SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2

Oliver Eales, Andrew J. Page, Leonardo de Oliveira Martins, Haowei Wang et autres

BACKGROUND: Since the emergence of SARS-CoV-2, evolutionary pressure has driven large increases in the transmissibility of the virus. However, with increasing levels of immunity through vaccination and natural infection the evolutionary pressure will switch towards immune escape. Genomic surveillance in regions of …

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Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning

Sema Nickbakhsh, Joseph Hughes, Nicolaos Christofidis, Emily Griffiths et autres

Whole genome sequencing of SARS-CoV-2 has occurred at an unprecedented scale, and can be exploited for characterising outbreak risks at the fine-scale needed to inform control strategies. One setting at continued risk of COVID-19 outbreaks are higher education institutions, associated with student …

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SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Brian J. Willett, Joe Grove, Oscar A. MacLean, Craig Wilkie et autres

Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino …

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COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study

Kerstin Kläser, Erika Molteni, Mark S. Graham, Liane S. Canas et autres

The Delta (B.1.617.2) variant was the predominant UK circulating SARS-CoV-2 strain between May and December 2021. How Delta infection compares with previous variants is unknown. This prospective observational cohort study assessed symptomatic adults participating in the app-based COVID Symptom Study who tested …

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Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Harald Vöhringer, Theo Sanderson, Matthew Sinnott, Nicola De Maio et autres

In the version of this article initially published, the name of author Erik Volz appeared as “Erik M. Volz” in The COVID-19 Genomics UK (COG-UK) Consortium contributions listings. Further, the affiliation listed for COG-UK Consortium member Adam A. Witney was shown incorrectly …

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