Accès ouvert
2024
preprint
OpenAlex
Matthew Dryden, Janice Toplass, Nicholas Cortes, Fabio Russo Del Piano et autres
Abstract Objective Many of the UK overseas territories are small with limited microbiological diagnostic capacity for pathogens and antimicrobial resistance detection. The Covid-19 pandemic highlighted the particular vulnerability of these territories for the emergence of novel infections and antimicrobial resistance. Methods The …
gb, gi, ms, au, fk, in, ca, us, tc, ky
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Accès ouvert
2024
article
OpenAlex
Joel M. Dulhunty, Stephen J. Brett, Jan J. De Waele, Dorrilyn Rajbhandari et autres
Importance: Whether β-lactam antibiotics administered by continuous compared with intermittent infusion reduces the risk of death in patients with sepsis is uncertain. Objective: To evaluate whether continuous vs intermittent infusion of a β-lactam antibiotic (piperacillin-tazobactam or meropenem) results in decreased all-cause mortality …
au, gb, be, nz, sg, fr
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Accès ouvert
2023
article
OpenAlex
Seb Cotton, M. McHugh, Rebecca Dewar, J.G. Haas et autres
BACKGROUND: The first epidemic wave of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Scotland resulted in high case numbers and mortality in care homes. In Lothian, over one-third of care homes reported an outbreak, while there was limited testing of hospital patients …
gb
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Accès ouvert
2022
erratum
OpenAlex
Brian J. Willett, Joe Grove, Oscar A. MacLean, Craig Wilkie et autres
In the version of this article initially published, the author affiliation information was incomplete, neglecting to note that Brian J. Willett, Joe Grove, Oscar A. MacLean, Craig Wilkie, Giuditta De Lorenzo, Wilhelm Furnon, Diego Cantoni, Sam Scott, Nicola Logan and Shirin Ashraf …
gb
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Accès ouvert
2022
article
OpenAlex
Emanuela Sozio, Nathan Moore, Martina Fabris, Andrea Ripoli et autres
BACKGROUND: Mid-Regional pro-Adrenomedullin (MR-proADM) is an inflammatory biomarker that improves the prognostic assessment of patients with sepsis, septic shock and organ failure. Previous studies of MR-proADM have primarily focussed on bacterial infections. A limited number of small and monocentric studies have examined …
it, gb, es, ch
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Accès ouvert
2022
article
OpenAlex
Oliver Eales, Andrew J. Page, Leonardo de Oliveira Martins, Haowei Wang et autres
BACKGROUND: Since the emergence of SARS-CoV-2, evolutionary pressure has driven large increases in the transmissibility of the virus. However, with increasing levels of immunity through vaccination and natural infection the evolutionary pressure will switch towards immune escape. Genomic surveillance in regions of …
gb
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Accès ouvert
2022
article
OpenAlex
Sema Nickbakhsh, Joseph Hughes, Nicolaos Christofidis, Emily Griffiths et autres
Whole genome sequencing of SARS-CoV-2 has occurred at an unprecedented scale, and can be exploited for characterising outbreak risks at the fine-scale needed to inform control strategies. One setting at continued risk of COVID-19 outbreaks are higher education institutions, associated with student …
gb
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Accès ouvert
2022
article
OpenAlex
Brian J. Willett, Joe Grove, Oscar A. MacLean, Craig Wilkie et autres
Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino …
gb
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Accès ouvert
2022
article
OpenAlex
Kerstin Kläser, Erika Molteni, Mark S. Graham, Liane S. Canas et autres
The Delta (B.1.617.2) variant was the predominant UK circulating SARS-CoV-2 strain between May and December 2021. How Delta infection compares with previous variants is unknown. This prospective observational cohort study assessed symptomatic adults participating in the app-based COVID Symptom Study who tested …
gb
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Accès ouvert
2022
erratum
OpenAlex
Harald Vöhringer, Theo Sanderson, Matthew Sinnott, Nicola De Maio et autres
In the version of this article initially published, the name of author Erik Volz appeared as “Erik M. Volz” in The COVID-19 Genomics UK (COG-UK) Consortium contributions listings. Further, the affiliation listed for COG-UK Consortium member Adam A. Witney was shown incorrectly …
gb
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2022
article
OpenAlex
Nathan Moore, Rebecca Williams, Matilde Mori, Beatrice Bertolusso et autres
AIMS: There is a lack of biomarkers validated for assessing clinical deterioration in patients with COVID-19 on presentation to secondary or tertiary care. This evaluation looked at the potential clinical application of C reactive protein (CRP), procalcitonin, mid-regional proadrenomedullin (MR-proADM) and white …
gb
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Accès ouvert
2021
article
OpenAlex
Harald Vöhringer, Theo Sanderson, Matthew Sinnott, Nicola De Maio et autres
The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the COVID-19 Genomics UK Consortium to reconstruct the dynamics of 71 …
gb
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