Vanyo Mitev

Bromhexine Prophylaxis and Pharmacologically Attenuated Natural Immunization: A Personalized Host-Directed Strategy Against SARS-CoV-2 and Influenza

Vanyo Mitev

Background: Bromhexine hydrochloride (BRH) has been proposed to functionally inhibit the host serine protease TMPRSS2, a key mediator of viral entry for SARS-CoV-2, influenza A and B viruses, and other respiratory viruses that depend on TMPRSS2-mediated proteolytic activation. Emerging evidence suggests that …

SNAPC4-related neurodevelopmental disorder defines a stage-dependent spliceosomopathy with heterogeneous clinical trajectories

Marcello Scala, Mohammad Sadegh Shams Nosrati, Alexandra Ruffus, Alireza Dostmohammadi et autres

it, de, fr, sa, us, nl, br, bg, gb, ca (code pays fourni par la source)

Colchicine and NLRP3 Inflammasome Inhibition in COVID-19 and Influenza: Current Evidence and Future Perspectives

Vanyo Mitev

Abstract Coronavirus disease 2019 (COVID-19) and influenza share key pathogenic mechanisms, including viral invasion, dysregulated innate immune activation, and the development of severe systemic complications. A central mediator of disease progression in both infections is the hyperactivation of the NLRP3 inflammasome, which …

Pilot survey among patients taking bromhexine prophylactically against influenza.

Vanyo Mitev, Violeta Dimitrova, Iva Miteva, Rumen Tiholov et autres

Background: The successful use of bromhexine hydrochloride (BRH) for COVID-19 prevention led us to apply the same method for flu prevention. The goal of this study is to observe whether BRH could protect people against influenza. Methods: This is noninterventional, observational, questionnaire-based …

bg, np (code pays fourni par la source)

Prolonged high-density culture with restricted medium renewal induces epithelial-like plasticity in apical papilla stem cells

Kameliya Kercheva, Marina Miteva, Silvia Kalenderova, Vanyo Mitev et autres

Stem cells from the apical papilla (SCAPs) are dental mesenchymal stem cells known for their high proliferative and multilineage potential. However, prolonged in vitro expansion may alter their phenotype due to microenvironmental stress. This exploratory study aimed to investigate whether prolonged high-density …

bg (code pays fourni par la source)

Early-Onset Oral Tongue Squamous Cell Carcinoma in the Absence of Traditional Risk Factors: A Case Report with Whole-Exome Sequencing Analysis

Evgeniy Aleksiev, Darina Lyudmilova Kachakova-Yordanova, Vanyo Mitev, Martin Marinov Georgiev et autres

Oral squamous cell carcinoma (OSCC) typically develops in individuals with established risk factors such as tobacco and alcohol use, yet an increasing number of cases occur in young non-smoking, non-drinking (NSND) patients. We report a case of oral tongue OSCC in a …

bg (code pays fourni par la source)

Differential Response of Stro-1+ and Stro-1− Shed to Er,Cr:YSGG Laser Stimulation: Viability, Matrix Production and Lineage Commitment

Zornitsa Mihaylova, Marina Miteva, Emilia Karova, Natalia Grancharova et autres

Stem cell heterogeneity represents a critical yet underexplored variable in laser-assisted regenerative strategies. While photobiomodulation has been shown to influence mesenchymal stem cell (MSC) behavior, it remains unclear whether stem cell maturation status modulates responsiveness to Er,Cr:YSGG irradiation. This study investigated the …

bg (code pays fourni par la source)

Pharmacoeconomic analysis of bromhexine for prophylactic of influenza A and B

Guenka Petrova, Vanyo Mitev

The aim of the present analysis is to assess the cost-effectiveness of influenza A and B prophylaxis with bromhexine, used off-label, for the purposes of the healthcare system in Bulgaria. Cost-effectiveness and cost–benefit analyses were performed from the payer and society perspectives. …

bg (code pays fourni par la source)

Erica spiculifolia Extract Potentiates Cisplatin Cytotoxicity by Reactivating p53 and Caspase-3-Dependent Apoptosis in Colorectal Carcinoma

Rositsa Mihaylova, Nikolay Bebrivenski, Dimitrina Zheleva-Dimitrova, Rumyana Simeonova et autres

extract (ESE) and its ability to synergistically enhance cisplatin cytotoxicity in HT-29 colorectal carcinoma cells. Cell viability was assessed using the MTT assay, followed by formal combination analysis based on the Chou-Talalay methodology. Combination experiments employed a non-constant ratio regimen in which …

bg (code pays fourni par la source)

SCN1A mutation spectrum in a cohort of Bulgarian patients with GEFS+ phenotype

Valentina Peycheva, Nevyana Ivanova, Kunka Kamenarova, Маргарита Панова et autres

BACKGROUND: Dravet syndrome (DS) is the most severe form of Generalized Epilepsy with Febrile Seizures plus (GEFS+) syndrome with a clear genetic component in 85% of the cases. It is characterized by fever-provoked seizure onset around six months of age and subsequent …

bg, by, be (code pays fourni par la source)