Violeta Dimitrova

Pilot survey among patients taking bromhexine prophylactically against influenza

Vanio Mitev, Violeta Dimitrova, Iva Miteva, Rumen Tiholov et autres

Background: The successful use of bromhexine hydrochloride (BRH) for COVID-19 prevention led us to apply the same method for flu prevention. The goal of this study is to observe whether BRH could protect people against influenza. Methods: This is noninterventional, observational, questionnaire-based …

bg, np (code pays fourni par la source)

Pilot survey among patients taking bromhexine prophylactically against influenza.

Vanyo Mitev, Violeta Dimitrova, Iva Miteva, Rumen Tiholov et autres

Background: The successful use of bromhexine hydrochloride (BRH) for COVID-19 prevention led us to apply the same method for flu prevention. The goal of this study is to observe whether BRH could protect people against influenza. Methods: This is noninterventional, observational, questionnaire-based …

bg, np (code pays fourni par la source)

Prolonged high-density culture with restricted medium renewal induces epithelial-like plasticity in apical papilla stem cells

Kameliya Kercheva, Marina Miteva, Silvia Kalenderova, Vanyo Mitev et autres

Stem cells from the apical papilla (SCAPs) are dental mesenchymal stem cells known for their high proliferative and multilineage potential. However, prolonged in vitro expansion may alter their phenotype due to microenvironmental stress. This exploratory study aimed to investigate whether prolonged high-density …

bg (code pays fourni par la source)

COVID‐19 Prophylactic Effect of Bromhexine Hydrochloride

Vanio Mitev, Tsanko Mondeshki, Konstantin Tashkov, Violeta Dimitrova

INTRODUCTION: Despite extensive efforts to identify effective treatments for COVID-19, preventive strategies remain essential. Bromhexine hydrochloride (BRH), an over-the-counter mucolytic with potential TMPRSS2 inhibition, may reduce viral entry and thus serve as a prophylactic agent. METHODS: A retrospective questionnaire-based study included 125 …

bg (code pays fourni par la source)

Defining the Stem Cell Niche in Developing Pericoronal Dental Follicles

Zornitsa Mihaylova, Marina Miteva, Maria Praskova, Silvia Kalenderova et autres

OBJECTIVE: The pericoronal dental follicle is a connective tissue structure encased in epithelium present around the developing tooth germ before erupting and emerging in the oral cavity. Stem cells from pericoronal follicles can be obtained and cultured under suitable conditions in vitro. …

bg, Afrique du Sud (code pays fourni par la source)

High colchicine doses are more effective in COVID-19 outpatients than nirmatrelvir/ritonavir, remdesivir, and molnupiravir

Vanio Mitev, Krasimir Marinov, Rumen Tiholov, Konstantin Tachkov et autres

Colchicine has an excellent basis for being effective against COVID-19 due to its anti-inflammatory, immunomodulatory, and cardioprotective effects, as well as its role in preventing microvascular thrombosis. In addition, colchicine also has antiviral effects, an extremely favorable safety profile, and–since it does …

bg, np (code pays fourni par la source)

Impact of dapagliflozin therapy on survival in heart failure patients with cancer in remission: a gender-based analysis

K Dyankov, Violeta Dimitrova, Kiril Karamfiloff

Abstract Background Heart failure (HF) remains a significant burden in patients with a history of cancer, as these individuals often experience worsened outcomes due to the combined effects of both conditions. Dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, has been shown to improve …

bg (code pays fourni par la source)

COVID-19 Prophylactic effect of Bromhexine Hydrochloride

Vanio Mitev, Tsanko Mondeshki, Ani Miteva, Konstantin Tashkov et autres

Despite the enormous efforts and funds spent to find an effective treatment for COVID-19, the results have been disappointing. In previous publications, we have demonstrated the remarkable effect of high-dose colchicine in inhibiting the cytokine storm and preventing multiorgan damage and death. …

bg (code pays fourni par la source)

Effects of long-term prophylaxis with bromhexine hydrochloride and treatment with high colchicine doses of COVID-19

Krasimir Marinov, Tsanko Mondeshki, Hristo Georgiev, Violeta Dimitrova et autres

In a series of publications, we attempt to demonstrate the prophylactic role of bromhexine hydrochloride (BHH) and the curative role of high colchicine doses against COVID-19. Effects of long-term prophylaxis with BHH are present with two cases of elderly women with severe …

np, bg (code pays fourni par la source)

Real-life data and the utility of echocardiography in young patients under 45 years with ischemic heart disease- a single-centered retrospective analysis

K Dyankov, Violeta Dimitrova, M. Radkova, Kiril Karamfiloff

Abstract Background In the last decade there is an increased incidence of coronary artery disease occurring in young adults ≤45-year-old who were referred for selective coronary angiography (SCAG). The traditional risk factors and approach are not informative and effective enough for adequate …

bg (code pays fourni par la source)

High Colchicine Doses Are More Effective in COVID-19 Outpatients than Nirmatrelvir/Ritonavir, Remdesivir, and Molnupiravir

Vanio Mitev, Krasimir Marinov, Rumen Tiholov, Konstantin Tashkov et autres

Colchicine has an excellent basis for being effective against COVID-19 due to its anti-inflammatory, immunomodulatory, cardioprotective effects, and prevention of microvascular thrombosis. In addition colchicine has also antiviral effect, extremely favorable safety profile and since it does not exert any overt immunosuppressive …

Effects of Long-Term Prophylaxis with Bromhexine Hydrochloride and Treatment with High Colchicine Doses of COVID-19

Krasimir Marinov, Tsanko Mondeshki, Hristo Georgiev, Violeta Dimitrova et autres

In a series of publications, we attempt to demonstrate the prophylactic role of bromhexine hydrochloride (BHH) and the curative role of high colchicine doses against COVID-19. Effects of long-term prophylaxis with BHH are presented in two cases of elderly women with severe …

np, bg (code pays fourni par la source)