Wen-Chi Hsieh

Hyperoside protects against poly-GR-mediated neurodegeneration via regulation of mitochondrial fission and oxidative stress in C9orf72-associated ALS

Wen-Chi Hsieh, Chun‐Yu Lin, Hsuan-Cheng Wu, Eddie Feng-Ju Weng et autres

Abstract Background Arginine-rich poly-glycine-arginine (poly-GR), a toxic dipeptide repeat protein generated from C9orf72 hexanucleotide repeat expansion, drives mitochondrial dysfunction, oxidative stress, and neuronal loss in amyotrophic lateral sclerosis (ALS). Hyperoside, a bioactive flavonoid, exhibits antioxidant and cytoprotective properties, but its therapeutic relevance …

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Additional file 2 of Hyperoside protects against poly-GR-mediated neurodegeneration via regulation of mitochondrial fission and oxidative stress in C9orf72-associated ALS

Wen-Chi Hsieh, Chun-Yu Lin, Hsuan-Cheng Wu, Eddie Feng-Ju Weng et autres

Supplementary material 2.

Additional file 2 of Hyperoside protects against poly-GR-mediated neurodegeneration via regulation of mitochondrial fission and oxidative stress in C9orf72-associated ALS

Wen-Chi Hsieh, Chun-Yu Lin, Hsuan-Cheng Wu, Eddie Feng-Ju Weng et autres

Supplementary material 2.

Additional file 1 of Hyperoside protects against poly-GR-mediated neurodegeneration via regulation of mitochondrial fission and oxidative stress in C9orf72-associated ALS

Wen-Chi Hsieh, Chun-Yu Lin, Hsuan-Cheng Wu, Eddie Feng-Ju Weng et autres

Supplementary material 1.

Additional file 1 of Hyperoside protects against poly-GR-mediated neurodegeneration via regulation of mitochondrial fission and oxidative stress in C9orf72-associated ALS

Wen-Chi Hsieh, Chun-Yu Lin, Hsuan-Cheng Wu, Eddie Feng-Ju Weng et autres

Supplementary material 1.

Poly-GR promotes ferroptosis-associated vulnerability in C9orf72-ALS

Chun‐Yu Lin, Wen-Chi Hsieh, Shao‐Ming Wang

Ferroptosis, an iron-dependent form of oxidative cell death driven by uncontrolled lipid peroxidation, has been increasingly implicated in neurodegeneration. However, its involvement and the underlying regulatory mechanism in C9orf72 -linked amyotrophic lateral sclerosis (ALS), the most common genetic form of the disease, …

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Calanquinone A suppresses glioma progression via STAT3-mediated regulation of c-Myc and MMP9

Wen-Chi Hsieh, Chun‐Yu Lin, Hsuan-Cheng Wu, Huei-Ru Lo et autres

Calanthe arisanensis, a traditional medicinal orchid, contains Calanquinone A, a quinone-type compound with reported anticancer properties. Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with limited treatment options and a poor prognosis. This study investigates the molecular mechanisms underlying the antiproliferative …

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Sigma-1R–Pom121 axis preserves nuclear transport and integrity in poly-PR-induced C9orf72 ALS

Chun‐Yu Lin, Hsuan-Cheng Wu, Ru‐Huei Fu, Eddie Feng-Ju Weng et autres

Nucleocytoplasmic transport disruption contributes to the pathogenesis of C9orf72 -associated amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Among the dipeptide repeat proteins translated from G4C2-repeat RNA, poly-PR is particularly toxic, compromising nuclear envelope integrity and transport. Here, we revealed that poly-PR reduced …

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