Chun‐Yu Lin

Multi-modal Offline Decomposition for Expertise: A Structural Approach to Robust Offline Meta-RL

Chun‐Yu Lin, Pei-Yuan Wu

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Hyperoside protects against poly-GR-mediated neurodegeneration via regulation of mitochondrial fission and oxidative stress in C9orf72-associated ALS

Wen-Chi Hsieh, Chun‐Yu Lin, Hsuan-Cheng Wu, Eddie Feng-Ju Weng et autres

Abstract Background Arginine-rich poly-glycine-arginine (poly-GR), a toxic dipeptide repeat protein generated from C9orf72 hexanucleotide repeat expansion, drives mitochondrial dysfunction, oxidative stress, and neuronal loss in amyotrophic lateral sclerosis (ALS). Hyperoside, a bioactive flavonoid, exhibits antioxidant and cytoprotective properties, but its therapeutic relevance …

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Poly-GR promotes ferroptosis-associated vulnerability in C9orf72-ALS

Chun‐Yu Lin, Wen-Chi Hsieh, Shao‐Ming Wang

Ferroptosis, an iron-dependent form of oxidative cell death driven by uncontrolled lipid peroxidation, has been increasingly implicated in neurodegeneration. However, its involvement and the underlying regulatory mechanism in C9orf72 -linked amyotrophic lateral sclerosis (ALS), the most common genetic form of the disease, …

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Transanal versus robotic total mesorectal excision for mid- and low-rectal cancer: A single-center comparative cohort of 109 patients

Chang-Lin Lin, Ming-Cheng Chen, Chun‐Yu Lin, Shih-Wei Chiang et autres

Minimally invasive total mesorectal excision (TME) for rectal cancer can be performed via transanal TME (TaTME) or robotic TME (R-TME), yet comparative evidence in predominantly non-obese Asian cohorts remains limited. We evaluated a consecutive retrospective cohort during our institutional transition from TaTME …

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The Mueller matrix analysis of articular cartilage tissue using liquid crystal modules

Chi-Hsiang Lien, Chun‐Yu Lin, Shu‐Chun Chuang, Yi-Shan Lin et autres

This study investigates the polarization properties of articular cartilage tissue sections using Mueller matrix analysis with a liquid crystal-based imaging system. The surface region of the cartilage, which is rich in type II collagen, was selected for imaging. To analyze the polarization …

Light-scattering–assisted near-infrared spectroscopy for improved quantitative analysis of tissue chromophores and oxygenation

Vladimir Hovhannisyan, Yvonne Yuling Hu, Liang-Wei Chen, Chun‐Yu Lin et autres

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Vibration‐Mediated Recovery of Irradiated Osteocytes and Their Regulatory Role in Breast Cancer Bone Metastasis

Xin Song, Kimberly Seaman, Amel Sassi, Chun‐Yu Lin et autres

Radiotherapy is a cornerstone of breast cancer treatment, but it can unintentionally damage bone, causing bone loss and pain, with no currently effective therapeutic strategy available. While chemically mediated radioprotection is extensively studied, mechanically mediated radioprotection remains underexplored. Given its safety and …

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Integration of Primary Murine Osteocytes for In Vitro Mechanobiology Studies

Kimberly Seaman, Chun‐Yu Lin, Xin Song, Amel Sassi et autres

This article describes the isolation, culture, and integration of primary murine osteocytes on a microfluidic platform for in vitro mechanobiology studies. Osteocytes are mechanosensitive cells embedded within the bone matrix and regulate bone remodeling. The MLO-Y4 osteocyte-like cell line typically used for …

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Calanquinone A suppresses glioma progression via STAT3-mediated regulation of c-Myc and MMP9

Wen-Chi Hsieh, Chun‐Yu Lin, Hsuan-Cheng Wu, Huei-Ru Lo et autres

Calanthe arisanensis, a traditional medicinal orchid, contains Calanquinone A, a quinone-type compound with reported anticancer properties. Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with limited treatment options and a poor prognosis. This study investigates the molecular mechanisms underlying the antiproliferative …

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Effects of Adjuvant Respiratory Therapy on Secretion Expectoration and Treatment Adherence in Patients with Head and Neck Cancer Receiving Concurrent Chemo-Radiotherapy

Hsiu‐Ying Cho, Lan-Ti Chou, Chien‐Yu Lin, Hsiu-Feng Hsiao et autres

Background and Objectives: The common complaints of head and neck cancer patients receiving concurrent chemo-radiotherapy (CCRT) are dry mouth, dysphagia, trismus, hoarseness, sore throat, and oral mucosal damage, which result in retained secretions and difficult expectoration. We aimed to investigate the effect …

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Abstract 3479: iPSC-derived γδT with novel combinatorial KO demonstrated significant anti-tumor activity and extended longevity without cytokine support

Jhang-Sian Yu, Ming-Chung Ko, Chia-Hung Lin, Yi-Han Dai et autres

Abstract Induced pluripotent stem cell (iPSC)-derived cell treatment offers several competitive benefits, including consistency, homogeneity and unlimited dosage, in contrast to autologous and allogeneic donor-derived cell therapies. These attributes improve affordability and accessibility of medicines worldwide. Noteworthy, the effectiveness of T cell …

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Cost-effective and accuracy-oriented ℓ1-norm support vector machine for enhanced feature selection

Jing‐Rung Yu, Chun‐Yu Lin, Donald Lien

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