Junjiao Zhang

Dihydrotanshinone I promotes apoptosis and inhibits proliferation in SH-SY5Y neuroblastoma cells

Hao Wang, Kai Gao, Junjiao Zhang, Fan Zhang et autres

Introduction Dihydrotanshinone I is known to exhibit antineoplastic properties. However, its effects on neuroblastoma, a common pediatric malignancy, remain unexplored. This in vitro study investigated the effects of dihydrotanshinone I in SH-SY5Y neuroblastoma cells using proliferation, viability, apoptosis, and transcriptomic assays. Methods …

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High-throughput screening of SrxA1−xFeyB1−yO3 perovskites for low-temperature chemical looping air separation using graph neural networks

Jie ZHAO, Changqing DONG, Junjie XUE, Xiaoying HU et autres

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A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu et autres

Striatal medium spiny neurons expressing D1 dopamine receptors (D1-MSNs) are a key component in the direct pathway of the basal ganglia and exhibit chronically suppressed activity in Parkinson's disease. To enable selective anatomical and functional interrogation of D1-MSNs, we developed an adeno-associated …

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Circular RNA in human brain: Systematic review of synaptic functions and disease associations

Hongyuan Chu, Jianxiong Gui, Meiyu Dong, Renqiuguo Li et autres

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A machine learning approach for predicting thermal expansion in perovskite oxide cathodes via tolerance factor τ minimization

Jie Zhao, Changqing Dong, Junjie Xue, Xiaoying Hu et autres

The optimization of thermal expansion coefficient (TEC) values is important for high-temperature electrochemical devices. In this study, a machine learning framework was developed to predict TEC values of perovskite oxide cathodes for solid oxide fuel cells (SOFCs). To address the complexity of …

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Effects of Mn doping on the reactivity, elastic, and magnetic properties of α-Fe2O3 based on DFT calculation

Peng Wang, Changqing DONG, Junjie XUE, Qi Gao et autres

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Research on the LHV prediction for biomass fuel based on near-infrared spectroscopy and local model strategy

Yalong Xie, Han Yan, Changqing Dong, Junjie Xue et autres

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Heterogeneity of active mast cells, endothelial cells, and fibroblasts in hemophilic arthritis defined by synovial single-cell sequencing

Kun Chang Lin, Shuai Fan, Xiaoqiang Yang, Wenyuan Hou et autres

Recurrent synovial bleeding is the major cause of Hemophilic Arthritis (HA). Up to now, the transcriptomic profiles of bleeding syvonium in HA patient have largely remained unknown. Exploring the transcriptomic characteristics of synovium obtained from HA patients undergoing total knee arthroplasty (TKA), …

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Prediction of Oxygen Vacancy Formation Energy in Oxides Based on the Graph Neural Network Approach

Jie Zhao, Changqing Dong, Junjie Xue, Xiaoying Hu et autres

Oxygen vacancy formation energy ( E ovf ) prediction plays an important role in addressing the issue of performance evaluation in various applications of materials. In this study, a convolutional and attentional graph neural network (CAGNN) was proposed for the prediction of …

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Molecular messengers of the brain: tRNA-derived small RNAs at the crossroads of brain development and neurodevelopmental disorders

Ran Li, Xiaoli Li, Hao Wang, Hongyuan Chu et autres

Brain development is tightly regulated by different modulators and mechanisms. Disruptions in these processes underlie a spectrum of neurodevelopmental disorders. Among non-coding RNAs, which usually act as key regulators of brain development, tRNA-derived small RNAs (tsRNAs) have recently emerged as functional regulators, …

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Integrated design for ethylene glycol production based on plasma gasification and water electrolysis: Thermodynamic and economic analysis

Hongnan Yu, Heng Chen, Liangchen Yu, Zhan Liu et autres

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Proteome‐Wide and Immune Cell Phenotype Mendelian Randomization Highlights Immune Involvement in Genetic Generalized Epilepsy

Jianxiong Gui, Hongyuan Chu, Junjiao Zhang, Xiao Li et autres

INTRODUCTION: Genetic generalized epilepsy (GGE) involves polygenic inheritance, with emerging evidence implicating immune mechanisms in seizure pathogenesis. Unlike previous studies focusing on inflammation following seizures, we employed an integrative multi-omics approach to identify precipitating immune factors in GGE development. METHODS: Summary data …

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