Jianxiong Gui

Circular RNA in human brain: Systematic review of synaptic functions and disease associations

Hongyuan Chu, Jianxiong Gui, Meiyu Dong, Renqiuguo Li et autres

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Molecular messengers of the brain: tRNA-derived small RNAs at the crossroads of brain development and neurodevelopmental disorders

Ran Li, Xiaoli Li, Hao Wang, Hongyuan Chu et autres

Brain development is tightly regulated by different modulators and mechanisms. Disruptions in these processes underlie a spectrum of neurodevelopmental disorders. Among non-coding RNAs, which usually act as key regulators of brain development, tRNA-derived small RNAs (tsRNAs) have recently emerged as functional regulators, …

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The Activation of the Microglial NLRP3 Inflammasome Is Involved in Tuberous Sclerosis Complex-Related Neuroinflammation

Ran Ding, Linxue Meng, Lingman Wang, Ziyao Han et autres

Tuberous sclerosis complex (TSC) is a systemic disease caused by mutations in either the TSC1 (encoding hamartin) or TSC2 (encoding tuberin) gene, with mutations in the TSC2 gene potentially leading to more severe clinical symptoms. Neurological symptoms are a common clinical manifestation …

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Oral adverse events associated with antiseizure medications: An analysis of the FDA adverse event reporting system (FAERS) database

Jia Tian, Ying Zhu, Jianxiong Gui

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Proteome‐Wide and Immune Cell Phenotype Mendelian Randomization Highlights Immune Involvement in Genetic Generalized Epilepsy

Jianxiong Gui, Hongyuan Chu, Junjiao Zhang, Xiao Li et autres

INTRODUCTION: Genetic generalized epilepsy (GGE) involves polygenic inheritance, with emerging evidence implicating immune mechanisms in seizure pathogenesis. Unlike previous studies focusing on inflammation following seizures, we employed an integrative multi-omics approach to identify precipitating immune factors in GGE development. METHODS: Summary data …

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Psychiatric disorders with antiseizure medications in children: an analysis of the FDA adverse event reporting system database

Jianxiong Gui, Lingman Wang, Linxue Meng, Ximu Zhang et autres

BACKGROUND: Epilepsy is a chronic neurological disorder marked by a persistent tendency to generate seizures, leading to substantial cognitive, behavioral, and psychosocial consequences. This study investigated psychiatric disorder-related adverse events (AEs) associated with antiseizure medications (ASMs) in children using the Food and …

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Author response for "Proteome-Wide and Immune Cell Phenotype Mendelian Randomization Highlights Immune Involvement in Genetic Generalized Epilepsy"

Jianxiong Gui, Wenwei Liu

Mechanistic Insights into Drug-Induced Guillain–Barré Syndrome: A Large-Cohort Analysis of the FAERS Database

Jianxiong Gui, Xiao Li, Hongyuan Chu, Junjiao Zhang et autres

Background/Objectives: Drug-induced Guillain–Barré Syndrome (GBS) is a severe complication of pharmacotherapy. Previous research has established a connection between certain medications and higher GBS risk. However, a large-cohort analysis is crucial to reveal underlying biological mechanisms of drug-induced GBS. This study aimed to …

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Novel susceptibility genes for sleep apnea revealed by a cross-tissue transcriptome-wide association study

Linxue Meng, Jianxiong Gui, Ziyao Han, Xiaoyue Yang et autres

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D-Serine May Ameliorate Hippocampal Synaptic Plasticity Impairment Induced by Patients’ Anti-N-methyl-D-aspartate Receptor Antibodies in Mice

Hanyu Luo, Xiaoyue Yang, Jiaxin Yang, Ziyao Han et autres

Objective: To establish a mouse model of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and assess the potential therapeutic benefits of D-serine supplementation in mitigating synaptic plasticity impairments induced by anti-NMDAR antibodies. Methods: Anti-NMDAR antibodies were purified from cerebrospinal fluid (CSF) samples of patients diagnosed …

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Adverse events of nusinersen: a real-world drug safety surveillance study based on the FDA adverse event reporting system (FAERS) database

Xiaofang Zhang, Jianxiong Gui, Lingman Wang, Chunxue Jiang et autres

INTRODUCTION: Nusinersen, the initial FDA-approved medication, treats Spinal Muscular Atrophy. This study utilized the FDA's adverse event reporting system (FAERS) database to examine, evaluate, and provide substantiation for the safety of Nusinersen to assist in clinical decision-making. METHODS: Nusinersen-related adverse reaction signals …

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Identification and verification of key molecules in the epileptogenic process of focal cortical dysplasia

Lingman Wang, Jianxiong Gui, Ran Ding, Honghong Song et autres

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