Shuang Zhu

Hyperdense Capsule Sign at Noncontrast CT as an Indication for Middle Meningeal Artery Embolization for Nonacute Subdural Hematomas: A MAGIC-MT Trial Post Hoc Analysis

Ruiyuan Weng, Jiabin Su, Shengjun Zhou, Heng Yang et autres

A hyperdense capsule at noncontrast CT was associated with a lower incidence of symptomatic recurrence or progression among participants who underwent middle meningeal artery embolization versus standard care for nonacute subdural hematomas.

cn (code pays fourni par la source)

GPNMB and ATP6V1A interact to mediate microglia phagocytosis of multiple types of pathological particles

Mei Liu, Jianping Zhu, Jiawei Zheng, Xuan Han et autres

Pronounced elevation of glycoprotein non-metastatic melanoma B (GPNMB) is a common phenomenon in a variety of brain diseases, but the expression patterns, functions, and molecular signaling of GPNMB have not been well studied. Here, we showed that pathological factors, including neuronal degeneration …

cn, Rwanda (code pays fourni par la source)

Breaking the Trust Paradox: Machine Unlearning via Neighbor-Collaborative Forgetting and Regret Updating

Tongfei Liu, Yongyao Su, Shuang Zhu

cn (code pays fourni par la source)

Characterization of the Tumor Microenvironment in Osteosarcoma Identifies Prognostic- and Immunotherapy-Relevant Gene Signatures

Jianye Tan, Feng Xuhui, Hangxing Wu, Bingsheng Yang et autres

The osteosarcoma (OS) microenvironment is composed of tumor cells, immune cells, and stromal tissue and is emerging as a pivotal player in OS development and progression. Thus, microenvironment-targeted strategies are urgently needed to improve OS treatment outcomes. Using principal component analysis (PCA), …

cn (code pays fourni par la source)

Mitochondria-Targeted Degradable Nanocomposite Combined with Laser and Ultrasound for Synergistic Tumor Therapies

Shuang Zhu, Deqiang Wang, Xuehua Sun, Xinyu Li et autres

Although the development of safe and efficient cancer therapeutic agents is essential, this process remains challenging. In this study, a mitochondria-targeted degradable nanoplatform (PDA–MnO2-IR780) for synergistic photothermal, photodynamic, and sonodynamic tumor treatment was investigated. PDA–MnO2-IR780 exhibits superior photothermal properties owing to the …

cn (code pays fourni par la source)

14 Safety of biomedical nanomaterials

Shuang Zhu, Zhanjun Gu, Chunying Chen, Yuliang Zhao

In this chapter, we will discuss the safety concerns of nanomaterials in biomedical applications. Nanotechnology is nowadays widely studied for therapeutic and diagnostic purposes, and an increasing number of nanomedicines have been approved for clinical use. The rate of expansion of biomedical …

MnO 2 nanoflowers as a multifunctional nano-platform for enhanced photothermal/photodynamic therapy and MR imaging

Wanru Sun, Hui Ming Yu, Deqiang Wang, Youjie Li et autres

Photodynamic therapy (PDT) has been regarded as a promising strategy for tumor therapy. However, heterogeneous tumor microenvironments severely limit the efficacy of photodynamic therapy. In this work, a multifunctional theranostic platform (MnO2-SiO2-APTES&Ce6 (MSA&C)) was fabricated based on MnO2 nanoflowers, which afforded MRI-guided …

cn (code pays fourni par la source)

Peli1 signaling blockade attenuates congenital zika syndrome

Guangyu Li, Binbin Wang, Bing Tian, Junling Gao et autres

Zika virus (ZIKV) infects pregnant women and causes devastating congenital zika syndrome (CZS). How the virus is vertically transmitted to the fetus and induces neuronal loss remains unclear. We previously reported that Pellino (Peli)1, an E3 ubiquitin ligase, promotes p38MAPK activation in …

us (code pays fourni par la source)

Effects of high fat diet-induced obesity on vitamin D metabolism and tissue distribution in vitamin D deficient or supplemented mice

Chan Yoon Park, Yongho Shin, Jeong‐Han Kim, Shuang Zhu et autres

Abstract Background Vitamin D deficiency has been often observed in obese persons. One of the mechanisms suggested for low vitamin D status in obesity was decreased bioavailability of vitamin D (VD) due to sequestration in adipose tissue. However, only few studies have …

kr (code pays fourni par la source)

Neuronal Epac1 mediates retinal neurodegeneration in mouse models of ocular hypertension

Fan Xia, Wei Liu, Yonju Ha, Shuang Zhu et autres

us (code pays fourni par la source)

Neuronal Epac1 mediates retinal neurodegeneration in mouse models of ocular hypertension

Wei Liu, Yonju Ha, Fan Xia, Shuang Zhu et autres

Progressive loss of retinal ganglion cells (RGCs) leads to irreversible visual deficits in glaucoma. Here, we found that the level of cyclic AMP and the activity and expression of its mediator Epac1 were increased in retinas of two mouse models of ocular …

hk, cn, us (code pays fourni par la source)

Effects of Vitamin D Supplementation on 1, 25-dihydroxyvitamin D Metabolism and Its Impact on Adipose Tissue Inflammation in Obese Mice (P24-004-19)

Chan Yoon Park, Shuang Zhu, Young Sun Jung, Sung Nim Han

Adipose tissue expresses CYP27B1 and VDR, suggesting local metabolism and function of 1,25-dihydroxyvitamin D (1,25(OH)2D) in adipose tissue. Obesity has been associated with dysregulation of 1,25(OH)2D levels. We investigated effects of vitamin D supplementation on 1,25(OH)2D metabolism and its impact in adipose …

kr (code pays fourni par la source)