Zhanjun Gu

Cilia‐Structured Lipiodol Droplets Enable Long‐Term Transarterial Embolization Therapy by Nano‐Interlocking Adhesion

Sen Zhang, Han Bao, Xiaowei Chen, Shuang Zhu et autres

Transarterial embolization (TAE) offers an effective and minimally invasive therapy for unresectable hepatocellular carcinoma (HCC), one of the most lethal malignancies globally, but being limited by short-term embolization failure for example recanalization due to weak interfacial adhesion. Herein, we report cilia-structured lipiodol …

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Fullerenes and their derivatives for mitigating oxidative stress disorders: Anti-oxidative mechanistic insights, anti-oxidative damage applications and translational progress

Jiani Xie, Yan Zhou, Yuting Wu, Zhihan Zhang et autres

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Brachytherapy Combined with Cuproptosis-Inducing Radiosensitizer Overcomes Radioresistance in Triple-Negative Breast Cancer

Xue Wang, Chenglu Gu, Jie Zhang, Xihong Guo et autres

Acquired radioresistance remains a major clinical obstacle in triple-negative breast cancer (TNBC) radiotherapy. Here, we first report the combined use of an ultrasmall copper-doped hafnium oxide nanoradiosensitizer (US-HfO2:Cu, ∼10 nm) and 192Ir brachytherapy (BT) to address this issue. BT triggers radiation-responsive Cu+ …

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Engineered dual-responsive mucoadhesive hydrogel co-delivering fullerenol against radiation-induced vaginal injury and microbiota dysbiosis

Maoru Zhao, Chengyan Wang, Yi Huang, Liangdi Wang et autres

Radiation-induced vaginal injury (RIVI) is a prevalent complication following pelvic radiotherapy for gynecological cancers, which is mainly caused by severe mucosal oxidative stress triggered by highly destructive reactive oxygen species (ROS), such as hydroxyl radicals (·OH). Conventional prophylactic agents struggle due to …

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Tantalum‐Based Nanomaterials: From Properties to Biomedical Applications

Yutong Jin, Yupeng Zhang, C R Yang, Genxing Ren et autres

For decades, tantalum has been a cornerstone of surgical implants, highly favored for its excellent chemical stability and biocompatibility. With the emergence of nanotechnology, tantalum-based nanomaterials (TBNs) have become highly promising candidates in biomedical applications due to their adjustable physicochemical and biological …

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A Kangfuxin-Loaded Lipid Gel for the Management of Radiation Dermatitis: Repair and Protection

Tao Wang, Wei Zhang, Peipei Sun, Genxing Ren et autres

Radiation therapy often causes oxidative stress and inflammation in normal tissues due to the generation of excessive radiation-induced reactive oxygen species (ROS). This can subsequently lead to radiation-induced skin injury (RISI), which manifests as tissue damage ranging from dermatitis to ulcers. One …

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A pH-responsive layered double hydroxide nanoradiosensitizer for bone metastasis tumor

Chen Yang, Xue Wang, Miao Zhu, Shuo Shi et autres

Breast cancer bone metastasis causes severe complications, yet current radiotherapy has limitations in treating secondary metastases and protecting healthy tissues. This study introduces calcium gadolinium layered double hydroxide (CaGd-LDH), a novel nanoradiosensitizer combining gadolinium (Gd) and calcium (Ca 2+ ) in a …

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Harnessing extreme organisms adaptations to develop a radiation protection agent for radiation lung injury

Genxing Ren, Qiu Yang, FeiJie Zhou, HaiJun Peng et autres

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Fullerene for Reducing Acute Radiation Dermatitis in Patients Undergoing Radiotherapy for Head and Neck Cancer: A Phase II, Double-Blind, Randomized Controlled Trial

Zheran Liu, Xiaoxia Liu, Zhihui Li, Jiani Xie et autres

PURPOSE: Acute radiation dermatitis (ARD) is a common debilitating toxicity in patients with head and neck cancer receiving radiotherapy. Current evidence-based strategies for preventing ARD remain limited, and alternative approaches are needed to optimize care. METHODS: In this double-blind, randomized, controlled phase …

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Toxicity and biosafety optimizing in perovskite nanomaterials

Yupeng Zhang, Shuang Zhu, Yutong Jin, Haiwei Xu et autres

Perovskite nanomaterials demonstrate good optoelectronic properties with broad applications in photovoltaics, light emitting diode, and biomedicine. However, their potential biological toxicity poses significant challenges for safe use. This review systematically examines toxicity mechanisms primarily driven by lead ion release, which induces oxidative …

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Fullerenol–selexipag suspension alleviates contrast-induced acute kidney injury

Yang Shuai Qiu, Haijun Peng, W J Wang, Haiyang Jiang et autres

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HBOT-induced noncardiogenic pulmonary edema in acute carbon monoxide poisoning: A case report and mechanistic insights

Min-xue Yao, Yu-Yang Chen, Zhanjun Gu

RATIONALE: Acute carbon monoxide poisoning is a common medical emergency, and hyperbaric oxygen therapy (HBOT) serves as the cornerstone of treatment. Although rare, serious complications such as acute pulmonary edema (APE) can be life-threatening. Most reported cases involve patients with preexisting cardiac …

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